In silicodosimetry for a prostate cancer treatment using198Au nanoparticles.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-11-05 DOI:10.1088/2057-1976/ad8acc
Lucas Verdi Angelocci, Sabrina Spigaroli Sgrignoli, Carla Daruich de Souza, Paula Cristina Guimarães Antunes, Maria Elisa Chuery Martins Rostelato, Carlos Alberto Zeituni
{"title":"<i>In silico</i>dosimetry for a prostate cancer treatment using<sup>198</sup>Au nanoparticles.","authors":"Lucas Verdi Angelocci, Sabrina Spigaroli Sgrignoli, Carla Daruich de Souza, Paula Cristina Guimarães Antunes, Maria Elisa Chuery Martins Rostelato, Carlos Alberto Zeituni","doi":"10.1088/2057-1976/ad8acc","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective</i>. To estimate dose rates delivered by using radioactive<sup>198</sup>Au nanoparticles for prostate cancer nanobrachytherapy, identifying contribution by photons and electrons emmited from the source.<i>Approach</i>. Utilizing<i>in silico</i>models, two different anatomical representations were compared: a mathematical model and a unstructured mesh model based on the International Commission on Radiological Protection (ICRP) Publication 145 phantom. Dose rates by activity were calculated to the tumor and nearby healthy tissues, including healthy prostate tissue, urinary bladder wall and rectum, using Monte Carlo code MCNP6.2.<i>Main results</i>. Results indicate that both models provide dose rate estimates within the same order of magnitude, with the mathematical model overestimating doses to the prostate and bladder by approximately 20% compared to the unstructured mesh model. The discrepancies for the tumor and rectum were below 4%. Photons emmited from the source were defined as the primary contributors to dose to other organs, while 97.9% of the dose to the tumor was due to electrons emmited from the source.<i>Significance</i>. Our findings emphasize the importance of model selection in dosimetry, particularly the advantages of using realistic anatomical phantoms for accurate dose calculations. The study demonstrates the feasibility and effectiveness of<sup>198</sup>Au nanoparticles in achieving high dose concentrations in tumor regions while minimizing exposure to surrounding healthy tissues. Beta emissions were found to be predominantly responsible for tumor dose delivery, reinforcing the potential of<sup>198</sup>Au nanoparticles in localized radiation therapy. We advocate for using realistic body phantoms in further research to enhance reliability in dosimetry for nanobrachytherapy, as the field still lacks dedicated protocols.</p>","PeriodicalId":8896,"journal":{"name":"Biomedical Physics & Engineering Express","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Physics & Engineering Express","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1088/2057-1976/ad8acc","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Objective. To estimate dose rates delivered by using radioactive198Au nanoparticles for prostate cancer nanobrachytherapy, identifying contribution by photons and electrons emmited from the source.Approach. Utilizingin silicomodels, two different anatomical representations were compared: a mathematical model and a unstructured mesh model based on the International Commission on Radiological Protection (ICRP) Publication 145 phantom. Dose rates by activity were calculated to the tumor and nearby healthy tissues, including healthy prostate tissue, urinary bladder wall and rectum, using Monte Carlo code MCNP6.2.Main results. Results indicate that both models provide dose rate estimates within the same order of magnitude, with the mathematical model overestimating doses to the prostate and bladder by approximately 20% compared to the unstructured mesh model. The discrepancies for the tumor and rectum were below 4%. Photons emmited from the source were defined as the primary contributors to dose to other organs, while 97.9% of the dose to the tumor was due to electrons emmited from the source.Significance. Our findings emphasize the importance of model selection in dosimetry, particularly the advantages of using realistic anatomical phantoms for accurate dose calculations. The study demonstrates the feasibility and effectiveness of198Au nanoparticles in achieving high dose concentrations in tumor regions while minimizing exposure to surrounding healthy tissues. Beta emissions were found to be predominantly responsible for tumor dose delivery, reinforcing the potential of198Au nanoparticles in localized radiation therapy. We advocate for using realistic body phantoms in further research to enhance reliability in dosimetry for nanobrachytherapy, as the field still lacks dedicated protocols.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
利用 198Au 纳米粒子进行前列腺癌治疗的硅模拟试验。
目标: 估算使用放射性198金纳米粒子进行前列腺癌纳米近距离治疗时的剂量率,确定放射源发射的光子和电子的贡献 方法: 利用硅模型,比较两种不同的解剖表示方法:一种是数学模型,另一种是基于国际放射防护委员会(ICRP)第145号出版物模型的非结构化网格模型。使用蒙特卡罗代码 MCNP6.2,按放射性活度计算了肿瘤和附近健康组织(包括健康的前列腺组织、膀胱壁和直肠)的剂量率。 主要结果: 结果表明,两种模型提供的剂量率估计值在同一数量级内,与非结构化网格模型相比,数学模型高估了前列腺和膀胱约 20% 的剂量。肿瘤和直肠的差异低于 4%。光源发射的光子被定义为其他器官剂量的主要来源,而肿瘤 97.9% 的剂量是由光源发射的电子造成的。这项研究证明了198金纳米粒子在肿瘤区域实现高剂量浓度的可行性和有效性,同时最大限度地减少了对周围健康组织的照射。研究发现,β发射是肿瘤剂量传递的主要原因,这加强了198金纳米粒子在局部放射治疗中的潜力。我们主张在进一步的研究中使用真实的人体模型,以提高纳米近距离放射治疗剂量测定的可靠性,因为该领域仍然缺乏专门的规程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
期刊最新文献
Optimizing pulmonary chest x-ray classification with stacked feature ensemble and swin transformer integration. Multi-level digital-twin models of pulmonary mechanics: correlation analysis of 3D CT lung volume and 2D Chest motion. Radar-based contactless heart beat detection with a modified Pan-Tompkins algorithm. Systematic characterization of new EBT4 radiochromic films in clinical x-ray beams. In silicodosimetry for a prostate cancer treatment using198Au nanoparticles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1