Unravelling the in vivo biotoxicity of green-biofabricated Graphene Oxide-Microplastic hybrid mediated by proximal intrinsic atomic interaction

IF 5.8 2区 环境科学与生态学 Q1 CHEMISTRY, MULTIDISCIPLINARY Environmental Science: Nano Pub Date : 2024-12-18 DOI:10.1039/d4en00558a
Adrija Sinha, Sudakshya S. Lenka, Abha Gupta, Dibyangshee Singh, Anmol Choudhury, Shaikh Sheeran Naser, Aishee Ghosh, Faizan Zarreen Simnani, Aditya Nandi, Suresh K Verma, Mrutyunjay Suar, Richa Mishra
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引用次数: 0

Abstract

Graphene Oxide (GO) nano-sheets have emerged as a potent nanomaterial for a range of applications like antibacterial, antibiofilm. Besides, Microplastic are emerging as a chronic pollutant originated from the aggrandized usage of plastics, for possessing serious repercussions to the living beings and the environment. In concern of the issue, the individual toxicological impacts of GO nano-sheets and Polystyrene (PS) have received substantial research, the mechanistic details and toxicological effects of GO and PS as a hybrid is yet unknown. This study evaluates the in vivo biotoxicity of a lab mimic green synthesized GO@PS hybrid using embryonic zebrafish through experimental and computational approach. The physiochemical characterzation of the GO@PS verified the synthesis of a stable 1433.0 ± 268.0 nm sized GO@PS hybrid with a zeta potential of -47.3 ± 5.7 mV. Mechanistic analysis deduced the toxicological impact as a cause of induced apoptosis due to dysregulated oxidative stress lead by the hypoxic condition created due to blockage of chorion by attachment and accumulation of GO@PS. The study depicted the in vivo toxicity of GO, PS and GO@PS at cellular and molecular level to draw attention for taking measures in usage of GO and PS in terms of environmental and human health.
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来源期刊
Environmental Science: Nano
Environmental Science: Nano CHEMISTRY, MULTIDISCIPLINARY-ENVIRONMENTAL SCIENCES
CiteScore
12.20
自引率
5.50%
发文量
290
审稿时长
2.1 months
期刊介绍: Environmental Science: Nano serves as a comprehensive and high-impact peer-reviewed source of information on the design and demonstration of engineered nanomaterials for environment-based applications. It also covers the interactions between engineered, natural, and incidental nanomaterials with biological and environmental systems. This scope includes, but is not limited to, the following topic areas: Novel nanomaterial-based applications for water, air, soil, food, and energy sustainability Nanomaterial interactions with biological systems and nanotoxicology Environmental fate, reactivity, and transformations of nanoscale materials Nanoscale processes in the environment Sustainable nanotechnology including rational nanomaterial design, life cycle assessment, risk/benefit analysis
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