Interaction and regulation of the mitochondrial proteome - in health and disease.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Expert Review of Proteomics Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI:10.1080/14789450.2025.2451704

Johan Palmfeldt

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Abstract

Introduction: Mitochondria contain multiple pathways including energy metabolism and several signaling and synthetic pathways. Mitochondrial proteomics is highly valuable for studying diseases including inherited metabolic disorders, complex and common disorders like neurodegeneration, diabetes, and cancer, since they all to some degree have mitochondrial underpinnings.

Areas covered: The main mitochondrial functions and pathways are outlined, and systematic protein lists are presented. The main energy metabolic pathways are as follows: iron-sulfur cluster synthesis, one carbon metabolism, catabolism of hydrogen sulfide, kynurenines and reactive oxygen species (ROS), and others, described with the aim of laying a foundation for systematic mitochondrial pathway analysis based on proteomics data. The links of the proteins and pathways to functional effects and diseases are discussed. The disease examples are focussed on inherited metabolic disorders, cancer, neurological, and cardiovascular disorders.

Expert opinion: To elucidate the role of mitochondria in health and disease, there is a need for comprehensive proteomics analyses with stringent, systematic data treatment for proper interpretation of mitochondrial pathway data. In that way, comprehensive hypothesis-based research can be performed based on proteomics data.

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线粒体蛋白质组在健康和疾病中的相互作用和调节。

线粒体包含多种途径，包括能量代谢和多种信号通路和合成途径。线粒体蛋白质组学在研究诸如遗传性代谢紊乱、神经退行性疾病、糖尿病和癌症等复杂和常见疾病方面具有很高的价值，因为它们在某种程度上都有线粒体的基础。涵盖领域：主要的线粒体功能和途径概述和系统的蛋白质列表提出。除了主要的能量代谢途径还有；铁硫簇合成、一碳代谢、硫化氢分解代谢、犬尿氨酸和活性氧（ROS）等，旨在为基于蛋白质组学数据的系统线粒体途径分析奠定基础。讨论了蛋白质和途径与功能效应和疾病的联系。疾病实例集中于遗传性代谢紊乱、癌症、神经和心血管疾病。专家意见：为了阐明线粒体在健康和疾病中的作用，需要进行全面的蛋白质组学分析，并进行严格、系统的数据处理，以正确解释线粒体通路数据。这样就可以基于蛋白质组学数据进行全面的基于假设的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.