Imaging of retinal ganglion cells and photoreceptors using Spatio-Temporal Optical Coherence Tomography (STOC-T) without hardware-based adaptive optics
Marta Mikuła-Zdańkowska , Dawid Borycki , Piotr Węgrzyn , Karolis Adomavičius , Egidijus Auksorius , Maciej Wojtkowski
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引用次数: 0
Abstract
We demonstrate an experimental Spatio-Temporal Optical Coherence Tomography (STOC-T) system featuring optimized illumination and an increased lateral resolution of approximately 3 µm. The integration of high-speed phase randomization with a numerical averaging process facilitates a noticeable improvement in the signal-to-noise ratio. The effectiveness of this enhancement is demonstrated through volumetric imaging of a scattering object, and it enables in vivo imaging of the human retina at the cellular level. Additionally, the experiment is supported by computational aberration-correction techniques to achieve high-resolution in vivo imaging of the human retina. The visualization of retinal cone mosaics, and ganglion cell somas was achieved through contrast enhancement during the averaging process.
期刊介绍：
Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
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