THE REGULATION OF CELL METABOLISM BY HYPOXIA AND HYPERCAPNIA.

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Biological Chemistry Pub Date : 2025-02-04 DOI:10.1016/j.jbc.2025.108252

Ben Reddan, Eoin P Cummins

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Abstract

Every cell in the body is exposed to a certain level of CO₂ and O₂. Hypercapnia and hypoxia elicit stress signals to influence cellular metabolism and function. Both conditions exert profound yet distinct effects on metabolic pathways and mitochondrial dynamics, highlighting the need for cells to adapt to changes in the gaseous microenvironment. The interplay between hypercapnia and hypoxia signalling is key for dictating cellular homeostasis as microenvironmental CO₂ and O₂ levels are inextricably linked. Hypercapnia, characterized by elevated pCO₂, introduces metabolic adaptations within the aerobic metabolism pathways, affecting TCA cycle flux, lipid, and amino acid metabolism, OXPHOS and the ETC. Hypoxia, defined by reduced oxygen availability, necessitates a shift from OXPHOS to anaerobic glycolysis to sustain ATP production, a process orchestrated by the stabilisation of HIF-1α. Given that hypoxia and hypercapnia are present in both physiological and cancerous microenvironments, how might the coexistence of hypercapnia and hypoxia influence metabolic pathways and cellular function in physiological niches and the tumor microenvironment?

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.