ASICs in PET: what we have and what we need.

IF 3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING EJNMMI Physics Pub Date : 2025-02-13 DOI:10.1186/s40658-025-00717-8
Vanessa Nadig, Stefan Gundacker, Katrin Herweg, Stephan Naunheim, David Schug, Bjoern Weissler, Volkmar Schulz
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引用次数: 0

Abstract

Background: Designing positron emission tomography (PET) scanners involves several significant challenges. These include the precise measurement of the time of arrival of signals, accurate integration of the pulse shape, maintaining low power consumption, and supporting the readout of thousands of channels. To address these challenges, researchers and engineers frequently develop application-specific integrated circuits (ASICs), which are custom-designed readout electronics optimized for specific tasks. As a result, a wide range of ASIC solutions has emerged in PET applications. However, there is currently no comprehensive or standardized comparison of these ASIC designs across the field.

Methods: In this paper, we evaluate the requirements posed to readout electronics in the field of PET, give an overview of the most important ASICs available for PET applications and discuss how to characterize their essential features and performance parameters. We thoroughly review the hardware characteristics of the different circuits, such as the number of readout channels provided, their power consumption, input and output design. Furthermore, we summarize their performance as characterized in literature.

Results: While the ASICs described show common trends towards lower power consumption or a higher number of readout channels over the past two decades, their characteristics and also their performance assessment by the developers, producers and vendors differ in many aspects. To cope with the challenge of selecting a suitable ASIC for a given purpose and PET application from the varying information available, this article suggests a protocol to assess an ASIC's performance parameters and characteristics.

Conclusion: ASICs developed for PET applications are versatile. With novel benchmarks set for the impact of scintillator and photosensor on the time-of-flight performance, the pressure on ASICs to deliver higher timing resolution and cope with an even higher data rate is enormous. Latest developments promise new circuits and improvements in time-of-flight performance. This article provides an overview on existing and emerging readout solutions in PET over the past 20 years, which is currently lacking in literature.

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来源期刊
EJNMMI Physics
EJNMMI Physics Physics and Astronomy-Radiation
CiteScore
6.70
自引率
10.00%
发文量
78
审稿时长
13 weeks
期刊介绍: EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
期刊最新文献
ASICs in PET: what we have and what we need. A generative whole-brain segmentation model for positron emission tomography images. On the reduction of imaging time-points for dosimetry in radionuclide therapy. Discordance between 90Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass microspheres. Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner.
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