Mammaglobin-A as a Diagnostic Marker of Canine Mammary Tumors: Insights from Immunohistochemical Analysis

IF 1.2 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES National Academy Science Letters Pub Date : 2024-09-28 DOI:10.1007/s40009-024-01444-x

Shikha Sharma, B. V. Sunil Kumar, Kuldip Gupta, Ashwani Kumar

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Abstract

Mammaglobin-A (MAM-A) is a glycoprotein predominantly linked to mammary tissue. It is a secretory protein, characterized by its composition of 93 amino acids and a molecular weight of around 10 kDa. The primary objective of this study is to evaluate the tissue expression of MAM-A in different histotypes of canine mammary tumors (CMT). The present study includes a total of 40 samples of CMT and 5 samples of apparently healthy canine mammary tissues, which were subjected to histological and immunohistochemical examinations. Hyperimmune serum was generated against recombinant MAM-A (rMAM-A) in rabbits to establish a standardized immunohistochemical protocol for evaluating the expression of MAM-A protein in different histotypes of CMT. The histological study demonstrated a wide array of tumor classifications, predominantly consisting of carcinoma, followed by carcinosarcoma and sarcoma. The immunohistochemical examination demonstrated a pronounced expression of MAM-A in the majority of CMT histotypes. The immunohistochemical expression of MAM-A in CMT indicates its potential as a valuable diagnostic biomarker.

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来源期刊

National Academy Science Letters 综合性期刊-综合性期刊

CiteScore

2.20

自引率

0.00%

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审稿时长

12 months

期刊介绍： The National Academy Science Letters is published by the National Academy of Sciences, India, since 1978. The publication of this unique journal was started with a view to give quick and wide publicity to the innovations in all fields of science