Inflammatory burden index (IBI) and body roundness index (BRI) in gallstone risk prediction: insights from NHANES 2017-2020.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2025-02-21 DOI:10.1186/s12944-025-02472-2

Yuting Gu, Zhanyi Zhou, Xuan Zhao, Xiaolu Ye, Keyi Qin, Jiahui Liu, Xiao Zhang, Yunxi Ji

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Abstract

Background: The Inflammatory Load Index (IBI) and Body Roundness Index (BRI) were employed to evaluate the systemic inflammatory status and body fat. This study aims to elucidate the association between IBI and the prevalence of gallstones, as well as to analyze the mediating role of BRI in this association.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) (2017-2020) were utilized in our cross-sectional study. A total of 2598 participants aged ≥ 20 years were enrolled. The Boruta algorithm, a supervised classification feature selection method, is leveraged to identify the confounding variables most strongly associated with the prevalence of gallstones. Weighted multivariate logistic regression, restricted cubic splines (RCS), and subgroup analyses were employed to investigate the association between IBI and gallstones, assess the presence of a linear association, and evaluate the effect of IBI on gallstone risk across different populations. Finally, the mediating effect of BRI was examined.

Results: In the fully adjusted model, when IBI was in the highest tertile, each unit increase in IBI (corresponding to an increase of 1 in the natural logarithm of IBI) was linked to a 110.8% higher prevalence of gallstones (OR = 2.108, 95% CI: 1.109-4.005; P = 0.028). The odds ratio for gallstones increased with higher IBI levels across unadjusted, partially adjusted, and fully adjusted models (P for trend < 0.05). This positive association was confirmed to be linear by the RCS curve (P for nonlinear = 0.887). Subgroup analysis indicated that the risk of gallstones was significantly elevated in individuals aged ≥ 60, females, and those with a Poverty-to-Income Ratio (PIR) ≥ 2 (P < 0.05). Mediation analysis revealed that IBI had a significant indirect effect on gallstone prevalence through BRI, with an effect size of 0.0129 (95% CI: 0.0121-0.0136; P < 0.001), and the mediation contributed to 33.24% of the total effect.

Conclusions: This study demonstrates a significant linear positive relation of IBI to gallstone prevalence. Furthermore, BRI mediates the effect of IBI on gallstone risk. These findings provide a more precise inflammatory marker for gallstone prevention and treatment.

Trial registration: Not applicable.

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炎症负担指数（IBI）和身体圆度指数（BRI）在胆结石风险预测中的应用：来自NHANES 2017-2020的见解

研究背景：采用炎症负荷指数（IBI）和体圆度指数（BRI）评估全身炎症状态和体脂。本研究旨在阐明IBI与胆结石患病率之间的关系，并分析BRI在这一关系中的中介作用。方法：我们的横断面研究使用了美国国家健康与营养调查（NHANES）（2017-2020）的数据。共有2598名年龄≥20岁的受试者入组。Boruta算法是一种监督分类特征选择方法，用于识别与胆结石患病率最密切相关的混杂变量。采用加权多变量logistic回归、限制性三次样条（RCS）和亚组分析来调查IBI与胆结石之间的关系，评估线性关联的存在，并评估不同人群中IBI对胆结石风险的影响。最后，对BRI的中介作用进行了检验。结果：在完全调整模型中，当IBI处于最高分位数时，IBI每增加一个单位（对应于IBI的自然对数增加1），胆结石患病率增加110.8% (OR = 2.108, 95% CI: 1.109-4.005；p = 0.028)。在未调整、部分调整和完全调整的模型中，胆结石的优势比随着IBI水平的升高而增加（P为趋势）。结论：本研究表明IBI与胆结石患病率呈显著的线性正相关。此外，BRI介导了IBI对胆结石风险的影响。这些发现为胆结石的预防和治疗提供了更精确的炎症标志物。试验注册：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.