Risk factors for complications of tissue expansion: An updated systematic review and meta-analysis

IF 2.7 2区医学 Q1 SURGERY Surgery Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI:10.1016/j.surg.2025.109282

Min Jiang PhD, Xinzhu Liu PhD, Dawei Li PhD, Feng Baigong MM, Chuan'an Shen PhD

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Abstract

Background

This study aimed to summarize risk factors for complications of tissue expansion using a meta-analysis of cohort studies.

Methods

PubMed, Embase, and Cochrane Library were searched from January 1985 to January 2025 for retrospective cohort studies investigating at least one potential risk factor for complications of tissue expansion. The quality of individual studies was assessed using the Newcastle-Ottawa scale. We conducted meta-analysis with risk ratios calculated for complication event rates.

Results

This review included 19 studies involving 1,673 participants. Two distinct subgroups (children only, adults and children) were identified. Strong evidence indicated that lower limb (relative ratio, 1.73; 95% confidence interval, 1.27–2.37), burn (relative ratio, 1.45, 95% confidence interval, 1.07–1.95), and myelomeningocele (relative ratio, 1.82; 95% confidence interval, 1.22–2.70) were the risk factors for premature removal of expansion in both children and adults.

Conclusion

This review identified lower limb, burn, and myelomeningocele are risk factors for complications of tissue expansion. Identifying modifiable risk factors is an urgent priority to improve prevention and treatment outcomes.

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组织扩张并发症的危险因素：最新的系统回顾和荟萃分析

本研究旨在通过队列研究的荟萃分析来总结组织扩张并发症的危险因素。方法检索spubmed、Embase和Cochrane图书馆1985年1月至2025年1月期间的回顾性队列研究，调查至少一种组织扩张并发症的潜在危险因素。使用纽卡斯尔-渥太华量表评估个体研究的质量。我们进行了meta分析，计算了并发症发生率的风险比。结果本综述纳入19项研究，涉及1,673名受试者。确定了两个不同的亚组（仅儿童、成人和儿童）。有力证据显示下肢(相对比值，1.73；95%可信区间，1.27-2.37)，烧伤（相对比，1.45,95%可信区间，1.07-1.95），脊髓脊膜膨出(相对比，1.82；95%可信区间（1.22-2.70）是儿童和成人过早切除扩张体的危险因素。结论：下肢、烧伤和脊髓脊膜膨出是组织扩张并发症的危险因素。确定可改变的风险因素是改善预防和治疗结果的当务之急。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery 医学-外科

CiteScore

5.40

自引率

5.30%

发文量

687

审稿时长

64 days

期刊介绍： For 66 years, Surgery has published practical, authoritative information about procedures, clinical advances, and major trends shaping general surgery. Each issue features original scientific contributions and clinical reports. Peer-reviewed articles cover topics in oncology, trauma, gastrointestinal, vascular, and transplantation surgery. The journal also publishes papers from the meetings of its sponsoring societies, the Society of University Surgeons, the Central Surgical Association, and the American Association of Endocrine Surgeons.