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Comparative midterm ramifications of one anastomosis gastric bypass, Roux-en-Y gastric bypass, and sleeve gastrectomy: A retrospective cohort study of 6,234 patients 一次吻合胃旁路术、Roux-en-Y胃旁路术和袖式胃切除术的中期后果比较:6234例患者的回顾性队列研究
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-31 DOI: 10.1016/j.surg.2026.110083
Adi Vinograd MD, MPH , Lital Keinan Boker MD, PhD , Rita Dichtiar MPH , Alina Rosenberg PhD , Orly Romano-Zelekha PhD , Inbal Globus PhD

Background

One-anastomosis gastric bypass is a commonly performed metabolic bariatric surgery, yet comprehensive comparisons of its midterm outcomes with Roux-en-Y gastric bypass and sleeve gastrectomy remain limited. The study aimed to assess midterm outcomes, including weight loss and 3-year post–metabolic bariatric surgery complications, in a nationwide cohort.

Methods

This retrospective cohort study included patients aged ≥18 years who underwent one-anastomosis gastric bypass, Roux-en-Y gastric bypass, or sleeve gastrectomy between 2016 and 2019, using data from the National Metabolic Bariatric Surgery Registry and Maccabi Health Services, the second largest health provider. Adjusted odds ratios for study outcomes were estimated using multivariable logistic regressions and propensity score matching.

Results

The study comprised 2,249 one-anastomosis gastric bypass (36.1%), 447 Roux-en-Y gastric bypass (7.2%), and 3,538 sleeve gastrectomy (56.8%) patients. Preoperative mean body mass index values were 41.3 ± 4.9, 40.4 ± 4.7, and 41.6 ± 4.9 kg/m2 for one-anastomosis gastric bypass, Roux-en-Y gastric bypass, and sleeve gastrectomy, respectively. One-anastomosis gastric bypass achieved the greatest weight-loss efficacy of 30.9% at 3 years of follow-up (P < .001). One-anastomosis gastric bypass was associated with higher odds of anal fissure (adjusted odds ratio, 1.85; 95% confidence interval, 1.38–2.49) alongside lower odds of constipation (adjusted odds ratio, 0.62; 95% confidence interval, 0.49–0.79), compared with sleeve gastrectomy. Both one-anastomosis gastric bypass and Roux-en-Y gastric bypass were associated with a higher likelihood of abdominal pain, diarrhea, and stomach ulcers compared with sleeve gastrectomy, after adjustment for potential confounders.

Conclusion

One-anastomosis gastric bypass demonstrated a greater magnitude of weight loss compared with sleeve gastrectomy but was associated with a higher incidence of specific gastrointestinal complications. These findings suggest additional considerations when selecting the optimal metabolic bariatric surgery approach, alongside tailored postoperative surveillance.
背景:吻合式胃旁路术是一种常用的代谢性减肥手术,但其中期结果与Roux-en-Y胃旁路术和袖式胃切除术的综合比较仍然有限。该研究旨在评估中期结果,包括体重减轻和3年后代谢减肥手术并发症,在全国范围内进行。方法本回顾性队列研究纳入了2016年至2019年期间接受单吻合术胃分流术、Roux-en-Y胃分流术或袖式胃切除术的年龄≥18岁的患者,数据来自国家代谢减肥手术登记处和第二大医疗服务提供者马卡比健康服务中心。使用多变量logistic回归和倾向评分匹配估计研究结果的调整优势比。结果共纳入单吻合术胃旁路2249例(36.1%),Roux-en-Y胃旁路447例(7.2%),套管胃切除术3538例(56.8%)。单吻合式胃旁路术、Roux-en-Y胃旁路术和袖式胃切除术术前平均体重指数分别为41.3±4.9、40.4±4.7和41.6±4.9 kg/m2。经3年随访,单吻合术胃旁路术的减重效果最高,达30.9% (P < .001)。与套式胃切除术相比,单吻合式胃旁路术发生肛裂的几率较高(校正优势比为1.85,95%可信区间为1.38-2.49),发生便秘的几率较低(校正优势比为0.62,95%可信区间为0.49-0.79)。调整潜在混杂因素后,单吻合术胃旁路术和Roux-en-Y胃旁路术与袖式胃切除术相比,腹痛、腹泻和胃溃疡的可能性更高。结论与套筒胃切除术相比,单吻合术胃旁路术体重减轻幅度更大,但特异性胃肠道并发症发生率更高。这些发现表明,在选择最佳的代谢减肥手术方法时,除了量身定制的术后监测外,还需要考虑其他因素。
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引用次数: 0
Analyzing costs versus savings using fluorescence angiography with indocyanine green for colorectal surgery in the United States: Multifaceted meta-analysis and cost analysis 在美国使用吲哚菁绿荧光血管造影进行结直肠手术的成本与节省分析:多方面的荟萃分析和成本分析
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-30 DOI: 10.1016/j.surg.2025.110072
Patrick Goldhawk-White BSc , Kevin White MD, PhD , Manish Chand MBA, PhD , Danny A. Sherwinter MD , Steven Wexner MD, PhD(Hon)

Background

Indocyanine green fluorescence angiography is being increasingly used in colorectal surgery to reduce anastomotic leak risk, but few studies have analyzed its cost efficacy. In this study, cost modeling was used to compare costs in the United States using versus not using indocyanine green fluorescence angiography.

Methods

Exhaustive searches of PubMed/MEDLINE, EMBASE, and Scopus were used to identify all meta-analyses and randomized controlled trials assessing the effectiveness of indocyanine green fluorescence angiography in reducing anastomotic leaks. Additionally, we conducted our own meta-analysis restricted to randomized controlled trials with ≥100 patients in both indocyanine green fluorescence angiography and control groups. Three years (2021–2023) of Medicare Provider Analysis and Review billing data were then employed to identify direct health care costs. Minimum, intermediate, and maximum cost analysis models were created using indocyanine green fluorescence angiography–associated anastomotic leak reduction rates identified by synthesizing the results of meta-analyses and randomized controlled trials, procedural and complication-related costs identified via Medicare Provider Analysis and Review, and $225 as the per-unit cost of indocyanine green administration.

Results

Synthesis of the results of our own and 19 published meta-analyses revealed a 51.9% reduction in anastomotic leak rate with indocyanine green fluorescence angiography, whereas 5 meta-analyses restricted to randomized controlled trials, including our own, revealed level 1 evidence of at least a 36.5% reduction. Minimum and maximum cost analysis models were generated using conservative anastomotic leak reduction rates of 35% and 50%, from which mean per-patient cost reductions ranged from $962 to $1,138, and overall health care system savings ranged from $71 million to $84 million.

Conclusion

For anastomotic assessments in colorectal surgery, indocyanine green fluorescence angiography reduces direct per-patient health care costs in the United States by $962 to $1,138. Additional savings may be derived from reduced rehospitalization and reoperation rates.
多菁绿荧光血管造影越来越多地应用于结直肠手术,以降低吻合口漏风险,但很少有研究分析其成本效益。在这项研究中,成本模型被用来比较美国使用与不使用吲哚菁绿色荧光血管造影术的成本。方法对PubMed/MEDLINE、EMBASE和Scopus进行全面检索,确定所有评估吲哚菁绿荧光血管造影减少吻合口瘘有效性的meta分析和随机对照试验。此外,我们进行了自己的荟萃分析,限制在≥100例患者的随机对照试验中,包括吲哚菁绿荧光血管造影组和对照组。然后使用三年(2021-2023)的医疗保险提供者分析和审查账单数据来确定直接医疗保健成本。通过综合meta分析和随机对照试验的结果确定的与吲哚菁绿荧光血管造影相关的吻合口漏减少率,通过医疗保险提供者分析和审查确定的程序和并发症相关成本,以及225美元作为吲哚菁绿给药的单位成本,建立了最小、中间和最大成本分析模型。结果:综合我们自己和19项已发表的荟萃分析的结果显示,吲哚菁绿荧光血管造影术的吻合口漏率降低了51.9%,而5项限于随机对照试验的荟萃分析,包括我们自己的荟萃分析,显示了至少降低36.5%的一级证据。最小和最大成本分析模型使用保守的吻合器泄漏减少率35%和50%生成,由此平均每位患者成本减少从962美元到1138美元不等,整体医疗保健系统节省从7100万美元到8400万美元不等。结论:在美国,对于结直肠手术的吻合口评估,吲哚菁绿荧光血管造影可使每位患者的直接医疗保健费用减少962美元至1138美元。再住院率和再手术率的降低可能带来额外的节省。
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引用次数: 0
Long-term parietal complications following surgery for inflammatory colitis: An underestimated issue 炎性结肠炎手术后的长期顶叶并发症:一个被低估的问题
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-30 DOI: 10.1016/j.surg.2026.110082
Océane Lelièvre MD , Solafah Abdalla MD, PhD , Aurélien Amiot MD, PhD , Antoine Meyer MD, PhD , Franck Carbonnel MD, PhD , Christophe Penna MD, PhD , Stéphane Benoist MD, PhD , Antoine Brouquet MD, PhD

Background

Surgical management of inflammatory colitis often requires a staged approach with multiple procedures. Data on incidence, risk factors, and management of parietal complications remain limited.

Methods

All adult patients who underwent surgery for inflammatory colitis between March 2010 and May 2024 were included. The primary endpoint was the incidence of incisional hernia, parastomal hernia, or stoma prolapse after complete surgical treatment. Risk factors were assessed, with age, body mass index ≥25 kg/m2, and permanent stoma retained for multivariate analysis.

Results

One hundred nine patients underwent surgery for refractory colitis (n = 32; 29%), severe acute colitis (n = 58; 54%), and dysplasia (n = 19; 17%). Single or staged procedures resulted in 73 ileal pouch-anal anastomoses (67%), 23 ileorectal anastomoses (21%), and 13 nonrestorative proctocolectomies with end ileostomy (12%). Eighty-four patients (77%) had temporary stomas, and 19 (17%) had permanent stomas. The median follow-up was 44 (interquartile range: 21–91) months. Twenty-five patients (23%) developed parietal complications after a median of 25 (interquartile range: 11–35) months: 22 (20%) incisional hernia, 4 (3.6%) parastomal hernia, and 3 (2.8%) stoma prolapse. None of the 4 patients with prophylactic biological mesh placement during stoma closure developed complications. Twenty patients underwent abdominal wall repair, with 6 (30%) recurrences and 3 (15%) redo surgeries. Permanent stoma was the only independent risk factor (odds ratio = 4.35, 95% confidence interval: 1.24–15.7; P = .022).

Conclusion

Nearly one-quarter of patients with inflammatory colitis develop parietal complications after surgery, with high recurrence after repair. Prophylactic mesh placement during stoma closure should be studied.
背景:炎性结肠炎的外科治疗通常需要分阶段进行多种手术。关于顶板并发症的发生率、危险因素和管理的数据仍然有限。方法纳入2010年3月至2024年5月期间接受炎性结肠炎手术治疗的所有成年患者。主要终点是手术治疗后切口疝、造口旁疝或造口脱垂的发生率。评估危险因素,年龄,体重指数≥25kg /m2,保留永久性造口进行多因素分析。结果顽固性结肠炎(32例,占29%)、严重急性结肠炎(58例,占54%)、发育不良(19例,占17%)共109例。单次或分期手术导致73例回肠袋-肛门吻合术(67%),23例回肠吻合术(21%),13例非恢复性直结肠切除术合并末端回肠造口术(12%)。84例(77%)为暂时性造口,19例(17%)为永久性造口。中位随访时间为44个月(四分位数间距:21-91)。25例患者(23%)在中位25个月(四分位间距:11-35)后出现顶骨并发症:22例(20%)切口疝,4例(3.6%)造口旁疝,3例(2.8%)造口脱垂。4例在造口术中预防性放置生物补片的患者均无并发症发生。20例患者接受腹壁修复,6例(30%)复发,3例(15%)重做手术。永久性造口是唯一的独立危险因素(优势比= 4.35,95%可信区间:1.24-15.7;P = 0.022)。结论近1 / 4的炎性结肠炎患者术后出现顶叶并发症,术后复发率高。应研究在造口过程中预防性放置补片。
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引用次数: 0
A missed opportunity to discuss treatment costs? A qualitative analysis of preoperative conversations about thyroid cancer treatment 错过了讨论治疗费用的机会?甲状腺癌治疗术前对话的定性分析
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-29 DOI: 10.1016/j.surg.2025.110075
Emily V. Crowley MS , Catherine B. Jensen MD, MSc , Elizabeth M. Bacon MPH , Benjamin C. James MD, MS , Susan C. Pitt MD, MPHS
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引用次数: 0
Integration of spatiotemporal features into machine learning assessment of open surgical skills 将时空特征整合到开放手术技能的机器学习评估中
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-28 DOI: 10.1016/j.surg.2025.110079
Armin Alipour MS , Jeffrey Balian BS , Kevin Tabibian BS , Oh Jin Kwon MD , Nguyen Le MS , Areti Tillou MD , Peyman Benharash MD

Introduction

Accurate and objective assessment of operative skills is essential for improving training paradigms, patient safety, and quality of surgery. Advances in machine learning have facilitated automated assessment of minimally invasive and robotic operations. This study aims to develop a novel machine learning model for evaluation of open surgical proficiency.

Methods

This study used the AIxSuture data set. A global rating score was assigned for each video, categorizing individuals into novice (n = 119), intermediate (n = 79), and proficient (n = 116) classes. Hybrid convolutional neural network and long-short-term-memory networks were employed to train the video classifier model. ResNet50, an image classification model, served as a spatial feature extractor to perform nonlinear transformations. Long-short-term-memory networks selectively retained and discarded both significant and insignificant changes in frame sets that capture the subject's movements. The class-wise F1 score was measured to assess harmonic performance.

Results

Our assessment achieved a mean F1 score of 80.1% in determining the performance level of each subject, outperforming previous models. Additionally, the model classified performance with 90.1% accuracy for the novice group, 65.7% for the intermediate group, and 86.3% for the proficient group. Despite lower accuracy in the intermediate class, this metric outperformed other models in this group by nearly 10%. The present model classified each video into appropriate skill levels at an estimated 10.2 ± 0.4 seconds.

Conclusions

Our machine learning model provides a robust framework for skill assessment in open surgery. The application of machine learning in clinical practice should be considered to evaluate surgeons' skills and help improve training and outcomes.
准确和客观的手术技能评估对于改善培训模式、患者安全和手术质量至关重要。机器学习的进步促进了微创手术和机器人手术的自动评估。本研究旨在开发一种新的机器学习模型来评估开放手术的熟练程度。方法本研究采用AIxSuture数据集。为每个视频分配一个全局评分,将个人分为新手(n = 119),中级(n = 79)和精通(n = 116)班。采用混合卷积神经网络和长短期记忆网络对视频分类器模型进行训练。利用图像分类模型ResNet50作为空间特征提取器进行非线性变换。长短期记忆网络选择性地保留和丢弃捕捉受试者运动的帧集中的重要和不重要的变化。测量班级一级F1分数以评估和声性能。结果我们的评估在确定每个受试者的表现水平方面的平均F1得分为80.1%,优于以往的模型。此外,该模型对新手组的分类准确率为90.1%,中级组为65.7%,熟练组为86.3%。尽管在中级类别中准确率较低,但该指标在该组中比其他模型高出近10%。目前的模型在10.2±0.4秒内将每个视频分类为适当的技能水平。结论我们的机器学习模型为开放性手术的技能评估提供了可靠的框架。应该考虑在临床实践中应用机器学习来评估外科医生的技能,并帮助改善培训和结果。
{"title":"Integration of spatiotemporal features into machine learning assessment of open surgical skills","authors":"Armin Alipour MS ,&nbsp;Jeffrey Balian BS ,&nbsp;Kevin Tabibian BS ,&nbsp;Oh Jin Kwon MD ,&nbsp;Nguyen Le MS ,&nbsp;Areti Tillou MD ,&nbsp;Peyman Benharash MD","doi":"10.1016/j.surg.2025.110079","DOIUrl":"10.1016/j.surg.2025.110079","url":null,"abstract":"<div><h3>Introduction</h3><div>Accurate and objective assessment of operative skills is essential for improving training paradigms, patient safety, and quality of surgery. Advances in machine learning have facilitated automated assessment of minimally invasive and robotic operations. This study aims to develop a novel machine learning model for evaluation of open surgical proficiency.</div></div><div><h3>Methods</h3><div>This study used the AIxSuture data set. A global rating score was assigned for each video, categorizing individuals into novice (<em>n</em> = 119), intermediate (<em>n</em> = 79), and proficient (<em>n</em> = 116) classes. Hybrid convolutional neural network and long-short-term-memory networks were employed to train the video classifier model. ResNet50, an image classification model, served as a spatial feature extractor to perform nonlinear transformations. Long-short-term-memory networks selectively retained and discarded both significant and insignificant changes in frame sets that capture the subject's movements. The class-wise F1 score was measured to assess harmonic performance.</div></div><div><h3>Results</h3><div>Our assessment achieved a mean F1 score of 80.1% in determining the performance level of each subject, outperforming previous models. Additionally, the model classified performance with 90.1% accuracy for the novice group, 65.7% for the intermediate group, and 86.3% for the proficient group. Despite lower accuracy in the intermediate class, this metric outperformed other models in this group by nearly 10%. The present model classified each video into appropriate skill levels at an estimated 10.2 ± 0.4 seconds.</div></div><div><h3>Conclusions</h3><div>Our machine learning model provides a robust framework for skill assessment in open surgery. The application of machine learning in clinical practice should be considered to evaluate surgeons' skills and help improve training and outcomes.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"192 ","pages":"Article 110079"},"PeriodicalIF":2.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cost comparison analysis of environmentally sustainable interventions in colorectal surgery 结直肠手术中环境可持续干预措施的成本比较分析
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-28 DOI: 10.1016/j.surg.2025.110054
Rabiya Aseem MBBS, MSc, MRCS , Siya Lodhia MBBS, MRCS , Timothy Rockall MBBS, MD, FRCS , Daniel Jackson BSc, MSc, PhD

Background

Operating theaters are significant contributors to hospital carbon emissions, with colorectal surgery offering substantial opportunities for sustainable transformations. Financial assessments are critical to aid sustainable implementation within health care organizations. We conducted a cost comparison analysis of substituting disposable surgical items with their reusable counterparts in colorectal surgeries.

Methods

This was a prospective cost comparison study across 65 consecutive elective laparoscopic colorectal resections at a single UK center. Interventions included reusable laparoscopic ports/trocars, a reusable harmonic device, and reusable textiles (gowns, drapes, and slide sheets). Costs were analyzed using a per-case unit (capital amortized over expected lifetime + per-use sterilization/laundering). We also conducted a two-way sensitivity analysis and a threshold (break-even) analysis with 6% discounting over a 5-year life span.

Results

The total observed savings across 65 cases were £14,239.03. The reusable harmonic device remained cost-saving in all two-way combinations, with savings of £24.7k–£28.5k over 65 cases (baseline of £26.6k). Reusable textiles were consistently cheaper than disposables across modeled volumes. Reusable ports did not demonstrate cost savings at observed volumes and prices and did not reach parity on threshold analysis. Findings were driven by processing costs, capital price, and utilization.

Conclusion

Selectively adopted reusables can deliver measurable financial savings, particularly the harmonic device and theatre textiles, whereas other items may remain cost-increasing at current volumes and prices. The per-case, two-way sensitivity framework is transferable and can be populated with local inputs to inform implementation decisions aligned with sustainability aims.
手术室是医院碳排放的重要贡献者,结直肠手术为可持续转型提供了大量机会。财务评估对于帮助卫生保健组织内的可持续实施至关重要。我们对结直肠手术中一次性手术用品与可重复使用手术用品替代的成本进行了比较分析。方法:这是一项前瞻性成本比较研究,在英国的一个中心进行了65例连续的选择性腹腔镜结肠直肠癌切除术。干预措施包括可重复使用的腹腔镜口/套管针、可重复使用的谐波装置和可重复使用的纺织品(长袍、窗帘和幻灯片)。成本分析采用个案单位(按预期寿命摊销的资本+每次使用的消毒/洗涤)。我们还进行了双向敏感性分析和阈值(盈亏平衡)分析,在5年的生命周期中有6%的折扣。结果65例观察到的总节省为14239.03英镑。可重复使用的谐波装置在所有双向组合中都节省了成本,在65例中节省了24.7万至28.5万英镑(基线为26.6万英镑)。在整个模型中,可重复使用的纺织品始终比一次性纺织品便宜。可重复使用的端口在观察到的数量和价格上没有显示出成本节约,并且在阈值分析中没有达到平价。结果是由加工成本、资本价格和利用率驱动的。有选择地采用可重复使用的材料可以节省可观的资金,尤其是谐波设备和剧院纺织品,而其他物品在当前的数量和价格下可能仍然会增加成本。每个案例的双向敏感性框架是可转移的,可以与当地的投入相结合,为符合可持续发展目标的实施决策提供信息。
{"title":"A cost comparison analysis of environmentally sustainable interventions in colorectal surgery","authors":"Rabiya Aseem MBBS, MSc, MRCS ,&nbsp;Siya Lodhia MBBS, MRCS ,&nbsp;Timothy Rockall MBBS, MD, FRCS ,&nbsp;Daniel Jackson BSc, MSc, PhD","doi":"10.1016/j.surg.2025.110054","DOIUrl":"10.1016/j.surg.2025.110054","url":null,"abstract":"<div><h3>Background</h3><div>Operating theaters are significant contributors to hospital carbon emissions, with colorectal surgery offering substantial opportunities for sustainable transformations. Financial assessments are critical to aid sustainable implementation within health care organizations. We conducted a cost comparison analysis of substituting disposable surgical items with their reusable counterparts in colorectal surgeries.</div></div><div><h3>Methods</h3><div>This was a prospective cost comparison study across 65 consecutive elective laparoscopic colorectal resections at a single UK center. Interventions included reusable laparoscopic ports/trocars, a reusable harmonic device, and reusable textiles (gowns, drapes, and slide sheets). Costs were analyzed using a per-case unit (capital amortized over expected lifetime + per-use sterilization/laundering). We also conducted a two-way sensitivity analysis and a threshold (break-even) analysis with 6% discounting over a 5-year life span.</div></div><div><h3>Results</h3><div>The total observed savings across 65 cases were £14,239.03. The reusable harmonic device remained cost-saving in all two-way combinations, with savings of £24.7k–£28.5k over 65 cases (baseline of £26.6k). Reusable textiles were consistently cheaper than disposables across modeled volumes. Reusable ports did not demonstrate cost savings at observed volumes and prices and did not reach parity on threshold analysis. Findings were driven by processing costs, capital price, and utilization.</div></div><div><h3>Conclusion</h3><div>Selectively adopted reusables can deliver measurable financial savings, particularly the harmonic device and theatre textiles, whereas other items may remain cost-increasing at current volumes and prices. The per-case, two-way sensitivity framework is transferable and can be populated with local inputs to inform implementation decisions aligned with sustainability aims.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"192 ","pages":"Article 110054"},"PeriodicalIF":2.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium and vitamin D reduce hypoparathyroidism and hospital stay after thyroidectomy: A randomized controlled trial 钙和维生素D减少甲状腺切除术后甲状旁腺功能减退和住院时间:一项随机对照试验
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-27 DOI: 10.1016/j.surg.2025.110071
Vasileios Gkanis MD, MSc , Konstantinos Nastos MD, PhD , Konstantinos Ntalaperas MD , Evangelia Agianni MD , Spyridon Lainas MD , Panagiota Raikou MD , Nikolaos Dafnios MD, PhD , Ioannis Papakonstantinou MD, PhD , Sophocles Lanitis MD, PhD

Background

Transient hypoparathyroidism is a common complication after total thyroidectomy, prolonging hospitalization and necessitating calcium and/or vitamin D replacement. Evidence from prospective randomized trials on preventive supplementation remains limited. This study aimed to evaluate whether prophylactic calcium and vitamin D supplementation reduces transient hypoparathyroidism and shortens hospital stay after total thyroidectomy.

Methods

In this single-center, prospective, randomized, controlled, open-label trial, 600 patients undergoing total thyroidectomy without central neck dissection were randomized to receive prophylactic oral calcium carbonate/gluconate and alfacalcidol (group A, n = 300) or standard postoperative care (group B, n = 300). Primary outcomes were biochemical and symptomatic hypocalcemia and the need for intravenous calcium. Secondary outcomes included postoperative serum calcium levels and length of hospital stay. Statistical analyses used χ2, Student’s t test, Mann-Whitney U test, and odds ratio and 95% confidence interval.

Results

Laboratory hypocalcemia (serum calcium <8.5 mg/dL) occurred significantly less often in group A (16.9% vs 39.9%; odds ratio 0.305, 95% confidence interval 0.207–0.451, P < .001). Symptomatic hypocalcemia was also reduced (5.6% vs 12.3%; odds ratio 0.427, 95% confidence interval 0.232–0.785, P < .005), as was the need for intravenous calcium (1.8% vs 9.3%; odds ratio 0.175, 95% confidence interval 0.070–0.441, P < .001). Group A demonstrated higher mean serum calcium levels on postoperative days 1 and 2 (P < .001) and a shorter hospital stay (1.25 days vs 1.7 days, P < .001). Supplementation benefits were consistent across subgroups stratified by malignancy status and preoperative vitamin D levels.

Conclusion

Routine calcium and vitamin D supplementation after total thyroidectomy significantly reduces transient hypoparathyroidism and shortens hospitalization. These findings support its use as a standard postoperative strategy to enhance recovery and reduce health care resource utilization.
背景:一过性甲状旁腺功能减退是全甲状腺切除术后常见的并发症,延长住院时间,需要补钙和/或维生素D。预防性补充剂的前瞻性随机试验证据仍然有限。本研究旨在评估预防性补充钙和维生素D是否能减少甲状腺全切除术后短暂性甲状旁腺功能减退并缩短住院时间。方法在这项单中心、前瞻性、随机、对照、开放标签的试验中,600例行甲状腺全切除术但未行中央性颈部清扫术的患者被随机分为预防性口服碳酸钙/葡萄糖酸盐和阿法骨化醇组(A组,n = 300)或标准术后护理组(B组,n = 300)。主要结局是生化和症状性低钙血症以及静脉补钙的需要。次要结局包括术后血钙水平和住院时间。统计分析采用χ2、Student’s t检验、Mann-Whitney U检验、优势比和95%置信区间。结果A组实验室低钙血症(血钙≥8.5 mg/dL)发生率明显低于对照组(16.9% vs 39.9%;优势比0.305,95%可信区间0.207 ~ 0.451,P < 0.001)。症状性低钙血症也减少了(5.6% vs 12.3%;优势比0.427,95%可信区间0.232-0.785,P < 0.005),静脉补钙需求也减少了(1.8% vs 9.3%;优势比0.175,95%可信区间0.070-0.441,P < 0.001)。A组患者术后第1天和第2天平均血钙水平较高(P < 0.001),住院时间较短(1.25天vs 1.7天,P < 0.001)。根据恶性肿瘤状态和术前维生素D水平分层的亚组中,补充维生素D的益处是一致的。结论甲状腺全切除术后常规补充钙和维生素D可显著减少甲状旁腺功能减退,缩短住院时间。这些发现支持其作为标准的术后策略,以提高恢复和减少卫生保健资源的利用。
{"title":"Calcium and vitamin D reduce hypoparathyroidism and hospital stay after thyroidectomy: A randomized controlled trial","authors":"Vasileios Gkanis MD, MSc ,&nbsp;Konstantinos Nastos MD, PhD ,&nbsp;Konstantinos Ntalaperas MD ,&nbsp;Evangelia Agianni MD ,&nbsp;Spyridon Lainas MD ,&nbsp;Panagiota Raikou MD ,&nbsp;Nikolaos Dafnios MD, PhD ,&nbsp;Ioannis Papakonstantinou MD, PhD ,&nbsp;Sophocles Lanitis MD, PhD","doi":"10.1016/j.surg.2025.110071","DOIUrl":"10.1016/j.surg.2025.110071","url":null,"abstract":"<div><h3>Background</h3><div>Transient hypoparathyroidism is a common complication after total thyroidectomy, prolonging hospitalization and necessitating calcium and/or vitamin D replacement. Evidence from prospective randomized trials on preventive supplementation remains limited. This study aimed to evaluate whether prophylactic calcium and vitamin D supplementation reduces transient hypoparathyroidism and shortens hospital stay after total thyroidectomy.</div></div><div><h3>Methods</h3><div>In this single-center, prospective, randomized, controlled, open-label trial, 600 patients undergoing total thyroidectomy without central neck dissection were randomized to receive prophylactic oral calcium carbonate/gluconate and alfacalcidol (group A, <em>n</em> = 300) or standard postoperative care (group B, <em>n</em> = 300). Primary outcomes were biochemical and symptomatic hypocalcemia and the need for intravenous calcium. Secondary outcomes included postoperative serum calcium levels and length of hospital stay. Statistical analyses used χ<sup>2</sup>, Student’s <em>t</em> test, Mann-Whitney <em>U</em> test, and odds ratio and 95% confidence interval.</div></div><div><h3>Results</h3><div>Laboratory hypocalcemia (serum calcium &lt;8.5 mg/dL) occurred significantly less often in group A (16.9% vs 39.9%; odds ratio 0.305, 95% confidence interval 0.207–0.451, <em>P</em> &lt; .001). Symptomatic hypocalcemia was also reduced (5.6% vs 12.3%; odds ratio 0.427, 95% confidence interval 0.232–0.785, <em>P</em> &lt; .005), as was the need for intravenous calcium (1.8% vs 9.3%; odds ratio 0.175, 95% confidence interval 0.070–0.441, <em>P</em> &lt; .001). Group A demonstrated higher mean serum calcium levels on postoperative days 1 and 2 (<em>P</em> &lt; .001) and a shorter hospital stay (1.25 days vs 1.7 days, <em>P</em> &lt; .001). Supplementation benefits were consistent across subgroups stratified by malignancy status and preoperative vitamin D levels.</div></div><div><h3>Conclusion</h3><div>Routine calcium and vitamin D supplementation after total thyroidectomy significantly reduces transient hypoparathyroidism and shortens hospitalization. These findings support its use as a standard postoperative strategy to enhance recovery and reduce health care resource utilization.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"192 ","pages":"Article 110071"},"PeriodicalIF":2.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of a robotic pancreatoduodenectomy program: Navigating the learning curve with a liberal patient selection and conversion strategy 机器人胰十二指肠切除术项目的实施:通过自由的患者选择和转换策略导航学习曲线
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-27 DOI: 10.1016/j.surg.2025.110070
Zhi Ven Fong MD, MPH, DrPH , Chee-Chee Stucky MD , Po Hong Tan MBBS , Dillon Cheung MD , Stephanie Yu MD , Anita M. Moyer RN, OCN , Julie L. Hildebrand PA-C, MS , Hoe Yan Hor MBBS , Melody Tu MBBS , Rick Bold MD, MBA , Yu-Hui Chang MS, PhD , Nabil Wasif MD, MPH

Background

The robotic platform is being increasingly utilized to perform pancreatoduodenectomy, but implementation can be associated with a steep learning curve, and large number of cases is required to surmount it. We detail an approach for implementation of a robotic pancreatoduodenectomy program that incorporates a liberal patient selection and conversion strategy to achieve proficiency while maintaining outcomes.

Methods

Consecutive patients undergoing pancreatoduodenectomy from January 2018 to June 2025 were identified. A robotic pancreatoduodenectomy program was implemented in October 2023. Difference-in-difference models with patients identified in the National Surgical Quality Improvement Program during the same period as a control cohort were used.

Results

A total of 205 patients underwent pancreatoduodenectomy, 127 in the preimplementation period and 78 in the postimplementation period. Of the 78 pancreatoduodenectomies performed in the postimplementation period, 62 (79.5%) were performed robotically with a conversion rate of 19.4%. Compared with the preimplementation cohort, the postimplementation cohort had similar complication and mortality rates but shorter median length of stay (5 days vs 8 days, P < .0001). On difference-in-difference analyses, the institutional cohort was associated with an increase in robotic use after program implementation (+74.8%, P < .001) compared with the National Surgical Quality Improvement Program control cohort. The institutional cohort was also associated with fewer pancreatic fistulas (−12.3%, P = .02), shorter length of stay (−2.0 days, P < .001), and similar 30-day major morbidity (−9.3%, P = .14) and readmission (+7.3%, P = .13), as well as mortality rates (−1.7%, P = .45) after program implementation.

Conclusion

A robotic pancreatoduodenectomy program with a liberal patient selection and conversion strategy can be safely implemented while preserving overall outcomes compared with National Surgical Quality Improvement Program benchmarks.
机器人平台越来越多地用于胰十二指肠切除术,但实施可能与陡峭的学习曲线相关,并且需要大量病例来克服它。我们详细介绍了一种实施机器人胰十二指肠切除术的方法,该方法包括自由的患者选择和转换策略,以在保持结果的同时达到熟练程度。方法对2018年1月至2025年6月连续行胰十二指肠切除术的患者进行分析。机器人胰十二指肠切除术项目于2023年10月实施。在国家外科质量改进计划中确定的患者在同一时期作为对照队列使用差异中差异模型。结果205例患者行胰十二指肠切除术,其中术前127例,术后78例。在实施后实施的78例胰十二指肠切除术中,62例(79.5%)采用机器人手术,转换率为19.4%。与实施前队列相比,实施后队列的并发症和死亡率相似,但中位住院时间更短(5天vs 8天,P < 0.0001)。在差异分析中,与国家外科质量改进计划对照队列相比,机构队列与计划实施后机器人使用的增加相关(+74.8%,P < .001)。机构队列还与更少的胰腺瘘(- 12.3%,P = 0.02),更短的住院时间(- 2.0天,P < 001),以及类似的30天主要发病率(- 9.3%,P = 0.14)和再入院(+7.3%,P = 0.13)以及死亡率(- 1.7%,P = 0.45)相关。结论与国家手术质量改进计划基准相比,具有自由患者选择和转换策略的机器人胰十二指肠切除术可以安全实施,同时保持总体结果。
{"title":"Implementation of a robotic pancreatoduodenectomy program: Navigating the learning curve with a liberal patient selection and conversion strategy","authors":"Zhi Ven Fong MD, MPH, DrPH ,&nbsp;Chee-Chee Stucky MD ,&nbsp;Po Hong Tan MBBS ,&nbsp;Dillon Cheung MD ,&nbsp;Stephanie Yu MD ,&nbsp;Anita M. Moyer RN, OCN ,&nbsp;Julie L. Hildebrand PA-C, MS ,&nbsp;Hoe Yan Hor MBBS ,&nbsp;Melody Tu MBBS ,&nbsp;Rick Bold MD, MBA ,&nbsp;Yu-Hui Chang MS, PhD ,&nbsp;Nabil Wasif MD, MPH","doi":"10.1016/j.surg.2025.110070","DOIUrl":"10.1016/j.surg.2025.110070","url":null,"abstract":"<div><h3>Background</h3><div>The robotic platform is being increasingly utilized to perform pancreatoduodenectomy, but implementation can be associated with a steep learning curve, and large number of cases is required to surmount it. We detail an approach for implementation of a robotic pancreatoduodenectomy program that incorporates a liberal patient selection and conversion strategy to achieve proficiency while maintaining outcomes.</div></div><div><h3>Methods</h3><div>Consecutive patients undergoing pancreatoduodenectomy from January 2018 to June 2025 were identified. A robotic pancreatoduodenectomy program was implemented in October 2023. Difference-in-difference models with patients identified in the National Surgical Quality Improvement Program during the same period as a control cohort were used.</div></div><div><h3>Results</h3><div>A total of 205 patients underwent pancreatoduodenectomy, 127 in the preimplementation period and 78 in the postimplementation period. Of the 78 pancreatoduodenectomies performed in the postimplementation period, 62 (79.5%) were performed robotically with a conversion rate of 19.4%. Compared with the preimplementation cohort, the postimplementation cohort had similar complication and mortality rates but shorter median length of stay (5 days vs 8 days, <em>P</em> &lt; .0001). On difference-in-difference analyses, the institutional cohort was associated with an increase in robotic use after program implementation (+74.8%, <em>P</em> &lt; .001) compared with the National Surgical Quality Improvement Program control cohort. The institutional cohort was also associated with fewer pancreatic fistulas (−12.3%, <em>P</em> = .02), shorter length of stay (−2.0 days, <em>P</em> &lt; .001), and similar 30-day major morbidity (−9.3%, <em>P</em> = .14) and readmission (+7.3%, <em>P</em> = .13), as well as mortality rates (−1.7%, <em>P</em> = .45) after program implementation.</div></div><div><h3>Conclusion</h3><div>A robotic pancreatoduodenectomy program with a liberal patient selection and conversion strategy can be safely implemented while preserving overall outcomes compared with National Surgical Quality Improvement Program benchmarks.</div></div>","PeriodicalId":22152,"journal":{"name":"Surgery","volume":"192 ","pages":"Article 110070"},"PeriodicalIF":2.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of young surgeons in surgical health policy advocacy engagement 年轻外科医生在外科健康政策宣传参与中的重要性
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-27 DOI: 10.1016/j.surg.2025.110066
Amy E. Liepert MD , Anthony Douglas MD , Alexandra Johns MD, MPH , Jay J. Doucet MD , Christina Colosimo DO, MS

Background

Despite its critical importance, health policy advocacy remains vastly underutilized among surgeons and represents a critical area for professional development. Yet, interest is growing among younger physicians, particularly early-career surgeons who increasingly view advocacy as integral to patient care. Amid a rapidly evolving health care landscape, advocacy is defined as physician efforts to influence social, economic, and political factors affecting health and is essential for addressing systemic challenges.

Methods

Millennials and GenZ are now entering in early to mid-stages of surgical practice and are transforming advocacy approaches. These generational cohorts have been shaped by digital technology, health care and insurance debates, and public health emergencies (eg firearm violence and COVID-19). They bring new energy and methods to health policy advocacy engagement. These digital natives prefer multichannel communication and virtual platforms, both of which facilitate participation while reducing clinical disruptions. Younger physicians see advocacy not as an optional task, but a professional responsibility aligned with leadership, autonomy, and systemic change.

Results

Despite support from competency frameworks such as Accreditation Council for Graduate Medical Education, formal training in advocacy remains limited, often relying on mentorship or experiential learning. It is imperative that we improve our engagement and education of surgeons interested in advocacy as we know there are benefits for the surgeons themselves, the surgical community, and society as a whole. Engaging in policy can help young surgeons influence major legislative and hospital-level decisions. It also builds skills in leadership, negotiation, and communication, while fostering resilience and reducing moral injury through agency and systemic change, and allows young surgeons to shape the future of their profession.

Conclusion

Engagement of young surgeons in advocacy is vital for improving patient care, ensuring professional autonomy and sustainability, and translating science into impactful health policy. Academic surgery programs can contribute to the improvement in education of residents and early-career surgeons with mentorship programs and collaborations with other departments to develop a robust network of surgeon health policy advocates.
尽管其至关重要,但卫生政策倡导在外科医生中仍未得到充分利用,是专业发展的关键领域。然而,年轻医生的兴趣正在增长,尤其是早期职业外科医生,他们越来越多地将倡导视为患者护理不可或缺的一部分。在快速发展的卫生保健环境中,倡导被定义为医生影响影响健康的社会、经济和政治因素的努力,对于解决系统性挑战至关重要。方法千禧一代和z世代现在正进入外科实践的早期到中期阶段,并正在改变宣传方法。这些世代群体受到数字技术、医疗保健和保险辩论以及突发公共卫生事件(例如枪支暴力和COVID-19)的影响。它们为卫生政策宣传参与带来了新的活力和方法。这些数字原生代更喜欢多渠道沟通和虚拟平台,这两者都有助于参与,同时减少临床干扰。年轻的医生认为倡导不是一个可有可无的任务,而是一种与领导、自主和系统变革相一致的专业责任。结果尽管有诸如研究生医学教育认证委员会等能力框架的支持,但倡导方面的正式培训仍然有限,往往依赖于指导或体验式学习。我们必须提高对倡导感兴趣的外科医生的参与和教育,因为我们知道这对外科医生自己、外科社区和整个社会都有好处。参与政策可以帮助年轻外科医生影响重大立法和医院一级的决定。它还培养领导、谈判和沟通技能,同时通过机构和系统变革培养韧性和减少道德伤害,并使年轻外科医生能够塑造其职业的未来。结论青年外科医生参与倡导对改善患者护理、确保专业自主性和可持续性以及将科学转化为有影响力的卫生政策至关重要。学术外科项目可以通过指导计划和与其他部门的合作,促进住院医师和早期职业外科医生的教育,以建立一个强大的外科医生健康政策倡导者网络。
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引用次数: 0
Factors associated with the feasibility and margin quality of sublobar resection for peripheral small-sized non–small cell lung cancer 影响外周非小细胞肺癌叶下切除术可行性和切缘质量的因素。
IF 2.7 2区 医学 Q1 SURGERY Pub Date : 2026-01-24 DOI: 10.1016/j.surg.2025.110080
Shusheng Zhu MM , Zhihua Li MM , Wenzheng Xu MD , Zhicheng He MD , Liang Chen MD , Weibing Wu MD

Objective

This study aimed to identify factors associated with the feasibility and margin quality of sublobar resection for peripheral small-sized non–small cell lung cancer (NSCLC).

Methods

Patients with peripheral small-sized non–small cell lung cancer (≤2 cm) who underwent sublobar resection or lobectomy between 2020 and 2023 were screened. Surgical procedures were determined through discussion under the guidance of 3-dimensional computed tomography bronchography and angiography. A surgical margin equal to or larger than the maximum tumor diameter was considered sufficient. Logistic regression analyses were used to screen factors associated with the feasibility and margin quality of sublobar resection. Predictive nomograms were developed for segmentectomy and wedge based on independent factors, respectively.

Results

There were 383 (51.3%), 286 (38.3%), and 78 patients (10.4%) undergoing wedge resection, segmentectomy, and lobectomy, respectively. The likelihood of achieving sufficient margins was 90.9% for segmentectomy and 74.4% for wedge resection. Overall, 545 of 747 patients (73.0%) received sublobar resection with sufficient margins. The multivariable logistic regression analysis (segmentectomy with insufficient margins or lobectomy = 1, segmentectomy with sufficient margins = 0) showed that tumor size, radiologic types, located lobes, tumor-to-segmental bronchus distance, and subsegmental attribution were significantly associated with the feasibility and margin quality of segmentectomy. For wedge resection, tumor size and Lewis types were significantly associated with its feasibility or margin quality. The predictive models exhibited good performance, with an area under the curve of 0.821 for segmentectomy and 0.765 for wedge resection.

Conclusion

Tumor size, radiologic types, located lobe, tumor-to-segmental bronchus distance, Lewis types, and subsegmental attribution types were associated with the feasibility and margin quality of sublobar resection.
目的:本研究旨在探讨影响外周小尺寸非小细胞肺癌(NSCLC)叶下切除术可行性和切缘质量的相关因素。方法:筛选2020 ~ 2023年间行叶下切除术或肺叶切除术的外周非小细胞肺癌(≤2 cm)患者。在三维计算机断层支气管造影和血管造影的指导下,通过讨论确定手术方法。手术切缘等于或大于最大肿瘤直径被认为是足够的。采用Logistic回归分析筛选与叶下切除术可行性和切缘质量相关的因素。基于独立因素,分别为节段性切除术和楔形切除术开发了预测图。结果:行楔形切除术383例(51.3%),节段切除术286例(38.3%),肺叶切除术78例(10.4%)。节段切除术获得足够切缘的可能性为90.9%,楔形切除术为74.4%。总体而言,747例患者中有545例(73.0%)接受了足够边缘的叶下切除术。多变量logistic回归分析(切缘不足的节段切除或肺叶切除= 1,切缘充足的节段切除= 0)显示,肿瘤大小、影像学类型、肺叶位置、肿瘤到支气管节段的距离、亚节段归因与节段切除的可行性和切缘质量显著相关。对于楔形切除术,肿瘤大小和Lewis类型与手术的可行性或切缘质量显著相关。预测模型表现良好,节段切除术的曲线下面积为0.821,楔形切除术的曲线下面积为0.765。结论:肿瘤大小、影像学类型、肺叶位置、肿瘤至支气管节段距离、Lewis型和亚节段归属类型与叶下切除术的可行性和切缘质量有关。
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引用次数: 0
期刊
Surgery
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