New oxepin and dihydrobenzofuran derivatives from Bauhinia saccocalyx roots and their anti-inflammatory, cytotoxic, and antioxidant activities.

IF 2.5 4区 医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2025-03-14 DOI:10.1007/s11418-025-01888-5
Lueacha Tabtimmai, Thanyathon Phonchan, Natrinee Thongprik, Sutin Kaennakam, Nuttapon Yodsin, Kiattawee Choowongkomon, Chanikan Sonklin, Supachai Jadsadajerm, Awat Wisetsai
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Abstract

Four new oxepin and dihydrobenzofuran derivatives, saccoxepins A-C (1-3) and saccobenzofurin A (4), along with one known compound, bauhinoxepin A (5), were isolated from the roots of Bauhinia saccocalyx. The structures were elucidated by extensive analysis of spectroscopic data in combination with ECD analysis. The EtOAc extract exhibited significant NO inhibition (94.4 ± 0.35%, 50 μg/mL), and saccoxepin A and bauhinoxepin A demonstrated strong NO suppression, with IC50 values of 49.35 µM and 30.28 µM, respectively, alongside notable antioxidant activity. Saccoxepin A and bauhinoxepin A selectively reduced interleukin-6 (IL-6) levels, while bauhinoxepin A slightly lowered tumor necrosis factor-alpha (TNF-α) at a low dose. Furthermore, bauhinoxepin A exhibited cytotoxicity against HCT-116 cells, with an IC50 of 8.88 µM. These findings suggest that the roots of B. saccocalyx possess potent antioxidant, anti-inflammatory, and anticancer activities, supporting its traditional medicinal applications and highlighting its potential as a source of therapeutic agents.

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从洋紫荆根中提取的新氧杂卓素和二氢苯并呋喃衍生物及其抗炎、细胞毒性和抗氧化活性。
从洋紫荆(Bauhinia saccocalyx)的根部分离出了四种新的氧西平和二氢苯并呋喃衍生物,即囊果西平 A-C (1-3) 和囊果苯并呋喃 A (4),以及一种已知化合物,即洋紫荆氧西平 A (5)。通过结合 ECD 分析对光谱数据进行广泛分析,阐明了这些化合物的结构。EtOAc 提取物对 NO 有明显的抑制作用(94.4 ± 0.35%,50 μg/mL),Saccoxepin A 和 bauhinoxepin A 对 NO 有很强的抑制作用,IC50 值分别为 49.35 µM 和 30.28 µM,同时还具有显著的抗氧化活性。Saccoxepin A 和 bauhinoxepin A 选择性地降低了白细胞介素-6(IL-6)的水平,而 bauhinoxepin A 则在低剂量时略微降低了肿瘤坏死因子-α(TNF-α)的水平。此外,牛黄解毒片 A 对 HCT-116 细胞具有细胞毒性,IC50 为 8.88 µM。这些研究结果表明,B. saccocalyx 的根具有强大的抗氧化、抗炎和抗癌活性,支持其传统医学应用,并突出了其作为治疗药物来源的潜力。
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来源期刊
CiteScore
6.90
自引率
3.00%
发文量
79
审稿时长
1.7 months
期刊介绍: The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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