Efficacy and Safety of 1064-nm Nanosecond Laser Modalities (Q-NDY and MDF Handpieces) for Treating Hand Skin Aging: A Prospective Randomized Controlled Trial
Jiying Dong, Shanshan Yao, Shen Wang, Min Yan, Nan Lu, Wenjuan Zhang, Min Yao
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Abstract
Background and Objectives: Hand aging is complex, and while laser treatments effectively address pigmentation, their precise impact on skin thickness and wrinkles remains unclear. This study evaluates the effects of two 1064-nm nanosecond laser modalities (Q-switched Nd:YAG laser (Q-NDY) and multidepth fractional laser (MDF)) on hand skin rejuvenation and safety.
Materials and Methods: A randomized controlled trial involving 20 patients with hand aging signs was conducted. Participants were randomized to the Q-NDY or MDF group, receiving three treatments at four-week intervals, followed by a three-month follow-up. Outcomes were evaluated by two independent plastic surgeons using an observer-reported scale. Skin physiology (thickness, melanin, and erythema indices) was measured, and patient satisfaction was assessed using the patient satisfaction scale (PSS).
Results: Both modalities improved pigmentation and reduced wrinkles. The MDF group showed significantly greater improvement in fine wrinkles (p = 0.0086) and skin texture (p = 0.0209) and a significant increase in skin thickness (p < 0.01), whereas the Q-NDY group did not. Melanin and erythema indices decreased significantly by week 20, with a greater reduction in erythema in the MDF group (p = 0.021). Overall satisfaction was 75% for Q-NDY and 90% for MDF.
Conclusion: Both 1064-nm nanosecond laser modalities rejuvenate hand skin. The MDF mode showed superior outcomes in wrinkle reduction, skin texture, and thickness, offering a safe and effective treatment option for hand rejuvenation.
Trial Registration: Chinese Registry of Clinical Trials: MR-31-23-013044
期刊介绍：
Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.
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