Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.

European journal of cardiology Pub Date : 1981-01-01
F Zannad, R J Royer, G Issartel, J Robert
{"title":"Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.","authors":"F Zannad,&nbsp;R J Royer,&nbsp;G Issartel,&nbsp;J Robert","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.</p>","PeriodicalId":72971,"journal":{"name":"European journal of cardiology","volume":"12 5","pages":"285-96"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of cardiology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
地高辛在老年人和肾衰竭中的应用。红细胞86-铷摄取试验的贡献
在三组不同年龄的受试者和一组肾功能衰竭患者中,通过测量患者自身红细胞中的86-铷摄取来间接评估Na+,K+- atp酶活性。地高辛对该活性的抑制作用也在体外进行了测定。发现老年人红细胞86Rb摄取较低,地高辛的计算分布体积也较低。对地高辛抑制作用的敏感性随年龄增长而增加。肾功能衰竭组86Rb摄取减少,对地高辛的敏感性变化。这表明Na+,K+- atp酶活性可能是地高辛分布体积的一个决定因素,该酶的定量和定性变化可以解释地高辛在肾衰竭和老年期的药代动力学特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Plasma pancreatic polypeptide and gastrin in the assessment of autonomic activity in acute myocardial infarction. Effects of intrinsic sympathetic activity of beta-blockers on SA and AV nodes in man. Coronary arterial stenosis and subclavian steal in Takayasu's arteritis. Changes in 86-rubidium uptake in erythrocytes of digoxin-treated patients, in heart failure with sinus rhythm. Relationship to clinical effects. Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1