Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.

European journal of cardiology Pub Date : 1981-01-01
F Zannad, R J Royer, G Issartel, J Robert
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Abstract

Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.

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地高辛在老年人和肾衰竭中的应用。红细胞86-铷摄取试验的贡献
在三组不同年龄的受试者和一组肾功能衰竭患者中,通过测量患者自身红细胞中的86-铷摄取来间接评估Na+,K+- atp酶活性。地高辛对该活性的抑制作用也在体外进行了测定。发现老年人红细胞86Rb摄取较低,地高辛的计算分布体积也较低。对地高辛抑制作用的敏感性随年龄增长而增加。肾功能衰竭组86Rb摄取减少,对地高辛的敏感性变化。这表明Na+,K+- atp酶活性可能是地高辛分布体积的一个决定因素,该酶的定量和定性变化可以解释地高辛在肾衰竭和老年期的药代动力学特征。
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Plasma pancreatic polypeptide and gastrin in the assessment of autonomic activity in acute myocardial infarction. Effects of intrinsic sympathetic activity of beta-blockers on SA and AV nodes in man. Coronary arterial stenosis and subclavian steal in Takayasu's arteritis. Changes in 86-rubidium uptake in erythrocytes of digoxin-treated patients, in heart failure with sinus rhythm. Relationship to clinical effects. Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.
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