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Changes of left ventricular contractility in alternating left bundle branch block. 交替左束支阻滞时左室收缩力的变化。
Pub Date : 1981-01-01
G Baduini, G Calcaterra, P Rossi

A case of intermittent and at times alternating, nonrate-dependent left bundle branch block, with alternation of normal and reduced indexes of contractility (dP/dt, dP/dt/P) in a borderline normal heart is reported. The reduction of left ventricular contractility in the presence of left bundle branch block, as compared to what is found by other authors, is supposedly related to a different location of the block in the left branch (peripheral vs high).

本文报道一例伴有正常和降低的收缩性指数(dP/dt, dP/dt/P)交替的边缘性正常心脏的间歇性和有时交替的非速率依赖性左束支传导阻滞。与其他作者的研究结果相比,左束支传导阻滞导致左心室收缩力降低,可能与左束支传导阻滞的位置不同有关(外周vs高位)。
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引用次数: 0
The role of the autonomic nervous system in patients with sinoatrial and atrioventricular node dysfunction. 自主神经系统在窦房结和房室结功能障碍患者中的作用。
Pub Date : 1981-01-01
H Boudoulas, S F Schaal, C V Leier, R P Lewis
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引用次数: 0
Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests. 地高辛在老年人和肾衰竭中的应用。红细胞86-铷摄取试验的贡献
Pub Date : 1981-01-01
F Zannad, R J Royer, G Issartel, J Robert

Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.

在三组不同年龄的受试者和一组肾功能衰竭患者中,通过测量患者自身红细胞中的86-铷摄取来间接评估Na+,K+- atp酶活性。地高辛对该活性的抑制作用也在体外进行了测定。发现老年人红细胞86Rb摄取较低,地高辛的计算分布体积也较低。对地高辛抑制作用的敏感性随年龄增长而增加。肾功能衰竭组86Rb摄取减少,对地高辛的敏感性变化。这表明Na+,K+- atp酶活性可能是地高辛分布体积的一个决定因素,该酶的定量和定性变化可以解释地高辛在肾衰竭和老年期的药代动力学特征。
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引用次数: 0
Plasma pancreatic polypeptide and gastrin in the assessment of autonomic activity in acute myocardial infarction. 血浆胰多肽和胃泌素对急性心肌梗死患者自主神经活动的评价。
Pub Date : 1981-01-01
M J Tansey, L H Opie, A Vinik, B M Kennelly

Measurements of plasma pancreatic polypeptide and gastrin are reported for the first time in patients with acute myocardial infarction and compared with clinical signs of vagal or sympathetic overactivity. Pancreatic polypeptide concentrations were assessed as an index of vagal activity, but elevated values of pancreatic polypeptide found in 7 of the 13 patients on admission did not correlate with clinical evidence of vagal overactivity. The mean pancreatic polypeptide concentrations were not higher in patients with clinical vagal overactivity than in patients with clinical sympathetic overactivity during the 12 h after the onset of symptoms of acute myocardial infarction. Mean gastrin levels were significantly higher on admission and at 4, 5, 6 and 8 h after the onset of infarction in the patients with clinical features of sympathetic overactivity than in the patients with clinical vagal overactivity. Thus plasma gastrin warrants further assessment as an index of sympathetic overactivity in acute myocardial infarction.

首次报道了急性心肌梗死患者血浆胰多肽和胃泌素的测定,并将其与迷走神经或交感神经过度活动的临床体征进行了比较。胰多肽浓度被评估为迷走神经活动的指标,但入院时13例患者中有7例胰多肽升高与迷走神经过度活动的临床证据无关。在急性心肌梗死症状出现后12小时内,临床迷走神经过度活跃患者的平均胰多肽浓度不高于临床交感神经过度活跃患者。以交感神经过度活跃为临床特征的患者入院时及梗死发生后4、5、6、8 h的平均胃泌素水平明显高于临床迷走神经过度活跃的患者。因此,血浆胃泌素作为急性心肌梗死交感神经过度活跃的指标值得进一步评估。
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引用次数: 0
Exercise-induced and variant form of angina pectoris in a patient with hypoplasia of the left coronary artery: clinical, metabolic and angiographic observations. 左冠状动脉发育不全患者运动诱发的变异性心绞痛:临床、代谢和血管造影观察
Pub Date : 1981-01-01
P J De Feyter, R Wardeh, P A Majid
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引用次数: 0
Coronary arterial stenosis and subclavian steal in Takayasu's arteritis. 高松动脉炎的冠状动脉狭窄和锁骨下窃血。
Pub Date : 1981-01-01
R Martín de Dios, J Pey, M Cazzaniga, E S Villarán, R F Espino, J M Brito, L Cerezo

This report describes a young boy with previous myocardial infarction and hypertension. Demonstration of coronary arterial ostial stenosis and a variant of subclavian steal was documented by selective arteriography. Surgical resolution of the most important stenosis is descending aorta, permitted effective control of hypertension. It is considered that one could reach this arteritis through different etiologies, tuberculosis having a preponderant place, and that it is important in all cases to carry out coronary arteriography.

本报告描述一年轻男孩既往心肌梗死和高血压。选择性动脉造影显示冠状动脉口狭窄和锁骨下窃血的变异。手术解决最重要的是降主动脉狭窄,使高血压得到有效控制。认为可以通过不同的病因达到这种动脉炎,结核有优势的地方,并认为在所有情况下进行冠状动脉造影是很重要的。
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引用次数: 0
A model for the generation of spontaneous yet predictable ventricular arrhythmias. 自发性但可预测的室性心律失常的发生模型。
Pub Date : 1981-01-01
S C Dennis, D J Hearse, D J Coltart

Development of an experimental preparation aided to investigate arrhythmogenic and antiarrhythmogenic factors influencing incidence of spontaneous and yet predictable ventricular arrhythmias is described. Using the isolated perfused guinea-pig heart and a system for quantitating rhythm disturbances based on computer-aided statistical analysis of beat-to-beat intervals, a number of factors influencing the incidence of rhythm disturbances were investigated. Manipulation of perfusate composition revealed that, after 'moderate' ischaemia, reperfusion arrhythmias were increased in the presence of noradrenaline and non-glucose fuels. Free fatty acids, unless in the presence of catecholamines, were not particularly arrhythmogenic. In contrast, the presence of pyruvate or lactate, endproduct inhibitors of glycolysis, significantly increased incidence of reflow rhythm disturbances. The dose-dependent arrhythmogenic effects of pyruvate and anti-arrhythmogenic effects of glucose support the thesis that inadequate glycolytic flux could be important in the development of arrhythmias.

一种实验制剂的发展,有助于研究影响自发性和可预测的室性心律失常发生率的致心律失常和抗心律失常因素。利用离体灌注豚鼠心脏和基于心跳间隔计算机辅助统计分析的心律失常定量系统,研究了影响心律失常发生率的若干因素。对灌注液成分的操作显示,在“中度”缺血后,在去甲肾上腺素和非葡萄糖燃料的存在下,再灌注心律失常增加。游离脂肪酸,除非存在儿茶酚胺,不是特别心律失常。相反,糖酵解的最终产物抑制剂丙酮酸或乳酸的存在显著增加了回流节律紊乱的发生率。丙酮酸的剂量依赖性致心律失常作用和葡萄糖的抗致心律失常作用支持了糖酵解通量不足可能是心律失常发生的重要因素这一论点。
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引用次数: 0
Haemodynamic reactions after intravenous injection of lorcainide hydrochloride in acute myocardial infarction. 静脉注射盐酸氯卡奈治疗急性心肌梗死后的血流动力学反应。
Pub Date : 1981-01-01
A Shita, R Bernard, R Mostinckx, M Debacker

Lorcainide hydrochloride given at the doses of 150 mg i.v. proved to be well tolerated at the acute stage of a myocardial infarction; the subjective signs were benign and never prevented us from completing the injection. The haemodynamic changes reflect some depressive effects on the myocardial function. Most of the observed changes are transient, and when significant from the statistical point of view, they remain very mild: the cardiac output decreased from 3.4 to 3.2 l/min per m2, the stroke index from 46 to 41 ml/m2, the pulmonary wedge pressure increases from 6.6 to 8.4 mm Hg (mean values). Lorcainide hydrochloride may thus be used as an antiarrhythmic drug in acute myocardial infarction.

盐酸氯卡奈150 mg静脉注射证明在心肌梗死急性期耐受性良好;主观征象是良性的,并没有阻止我们完成注射。血流动力学变化反映心肌功能受到一定的抑制作用。大多数观察到的变化是短暂的,从统计学角度来看,当显著时,它们仍然非常轻微:心输出量从3.4降至3.2 l/min /m2,卒中指数从46降至41 ml/m2,肺楔压从6.6上升至8.4 mmhg(平均值)。因此,盐酸氯卡奈可作为抗心律失常药物用于急性心肌梗死。
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引用次数: 0
Tardokinesis in coronary artery disease: evidence with instantaneous analysis of left ventricular ejection. 冠状动脉疾病迟滞运动:左心室射血瞬时分析的证据。
Pub Date : 1981-01-01
F Cucchini, G Baldi, A L Barilli, M Di Donato, O Visioli

Instantaneous measurements of ejection phase indices throughout the whole systole have been performed in 10 normal subjects (normal group), and in 8 coronary artery disease (CAD) patients (CAD group). All the patients of the CAD group were selected from 230 CAD patients because of their normal values in standard ejection phase indices (i.e. ejection fraction, EF; mean velocity of circumferential fiber shortening, VcfM; mean normalized systolic ejection rate, MNSER). An 'instantaneous' evaluation of the ventricular function, by means of a frame-by-frame analysis throughout the ejection period, allowed us to detect abnormalities of ventricular ejection in the early phase of systole in these CAD patients. In comparison with the control group, the CAD group presented similar peak values of dV/dt, dV/dt/EDV and Vcf, and a significantly longer time to peak values of these indices; EF curve analysis showed similar values at the end of systole in the two groups, but the mean curve of the CAD group was significantly lower in the first third of ejection when compared with that of control group. A segmental wall motion analysis in the early phase of systole showed a diffuse delayed ventricular wall motion (tardokinesis) related to abnormalities demonstrated by frame-by-frame analysis of ejection phase indices. Our results confirm that the CAD patients may have abnormalities of ventricular performance in the early phase of systole even when standard ejection phase indices are still within the normal range. In addition, the chronological appearance of these abnormalities during the whole systole has been clearly assessed; finally, these data confirm the importance of acceleration in blood ejection from the left ventricle as an index of ventricular function.

对10例正常受试者(正常组)和8例冠心病患者(冠心病组)进行了整个收缩期射血期指标的瞬时测量。所有CAD组患者均从230例CAD患者中选择,因为标准射血期指标(即射血分数,EF;纤维周向缩短平均速度VcfM;平均正常化收缩期射血率(MNSER)。通过对整个射血期逐帧分析,对心室功能进行“瞬时”评估,使我们能够在这些CAD患者的收缩期早期发现心室射血异常。与对照组相比,CAD组dV/dt、dV/dt/EDV、Vcf均出现相似的峰值,且出现峰值的时间明显长于对照组;两组在收缩期结束时EF曲线分析值相近,但CAD组在射血前三分之一的平均曲线明显低于对照组。收缩期早期的节段性心室壁运动分析显示弥漫性延迟心室壁运动(迟滞运动)与逐帧射血期指数分析显示的异常有关。我们的研究结果证实,即使标准射血期指标仍在正常范围内,CAD患者在收缩期早期也可能存在心室功能异常。此外,这些异常在整个收缩期的时间表现已被清楚地评估;最后,这些数据证实了左心室射血加速作为心室功能指标的重要性。
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引用次数: 0
Jugular pulse and flow velocity anomalies: a diagnostic clue to an obstructive tricuspid prosthetic dysfunction. 颈静脉脉搏和血流速度异常:阻塞性三尖瓣假体功能障碍的诊断线索。
Pub Date : 1981-01-01
C Veyrat, J Ollagnier, D Fremont, C H Savier, B Philippe, R Naouri, P Chiche

Report of a case of obstructive dysfunction of a tricuspid Starr-Edwards (6120) ball prosthesis, diagnosed on phonocardiographic (PCG) diastolic anomalies with abnormal diastolic pattern of the jugular pulse, abnormal jugular flow velocity curve, and confirmed by cinefluoroscopy. The thrombotic origin of the obstruction was assessed on the regression of PCG and cinefluoroscopic anomalies under fibrinolytic therapy.

报告1例三尖瓣Starr-Edwards(6120)球形假体梗阻性功能障碍,经心音图(PCG)诊断为舒张异常,颈静脉脉搏舒张模式异常,颈静脉血流速度曲线异常,并经电影x线检查证实。在纤维蛋白溶解治疗下,通过PCG和电影透视异常的回归来评估血栓性阻塞的起源。
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European journal of cardiology
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