Amiodarone-induced ventricular fibrillation.

European journal of cardiology Pub Date : 1980-01-01
J M McComb, K R Logan, M M Khan, J S Geddes, A A Adgey
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Abstract

Amiodarone, 600 mg orally daily, was used in an attempt to control supraventricular tachyarrhythmias in a patient with the sick sinus syndrome. Twenty days from the onset of therapy the Q-T interval lengthened. Episodes of ventricular flutter, ventricular fibrillation and self-terminating ventricular tachyarrhythmia (torsade de pointes) developed on the 28th day of amiodarone therapy. Temporary cardiac pacing prevented further episodes of ventricular fibrillation. Despite the suggestion that this drug may be given in large doses for long periods of time since it has a wide safety margin, we feel that the risk of lethal arrhythmias is such that caution is required in its use.

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胺碘酮引起的心室颤动。
胺碘酮,600毫克,每日口服,用于控制病人的室上性心动过速与病态窦综合征。治疗开始后20天,Q-T间期延长。在胺碘酮治疗第28天出现心室扑动、心室颤动和自终止性室性心动过速(扭转点)发作。临时心脏起搏可防止心室颤动的进一步发作。尽管这种药物有很大的安全范围,因此建议可以长期大剂量服用,但我们认为,致命心律失常的风险是如此之大,因此在使用时需要谨慎。
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