Response time and heart rate in coronary patients under mild mental stress.

European journal of cardiology Pub Date : 1980-01-01
D A Sideris, J N Nanas, S Thomakos, S D Moulopoulos
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Abstract

A mild mental stress was applied on 39 normal people and on 33 patients with coronary artery disease. The test consisted in their selecting the proper switch out of 2, in order to switch off a lamp out of 3 as soon as possible after its ignition. The 3 lamps were lit by the examiner in a stereotyped random sequence. No consequences were implied against the subjects in case of failure and this was clearly explained to them. The response time of the people was recorded together with their electrocardiogram in a one-channel recorder using a suitable circuitry. The study showed that the response time became progressively shorter during the test only in the coronary group, although the mean value did not differ significantly from that in the normal group. The R-R interval was shortened in both groups but in the coronary group significantly more so than in the normal group. Pretreatment with diazepam reversed both responses of the coronary group. Pretreatment with propranolol mitigated the tachycardiac effect of the test in the coronary group, reversed its effect in the normal group and shortened the response time significantly in the normal group. The objective time measurements by the device used might suggest that in patients with coronary artery disease both the specific (response time) and the nonspecific (R-R interval) behaviour in response to a mental stress differ from that in normal people. This behaviour may be modified by medicaments like diazepam and propranolol.

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轻度精神压力下冠心病患者的反应时间和心率。
对39名正常人和33名冠状动脉疾病患者施加轻度精神压力。测试包括从2个开关中选择合适的开关,以便在3个灯点燃后尽快关闭灯。这三盏灯由考官按固定的随机顺序点燃。如果失败,不会对受试者造成任何后果,并向他们清楚地解释了这一点。人们的反应时间和他们的心电图一起记录在一个单通道记录仪上,使用合适的电路。研究表明,只有冠状动脉组在测试过程中反应时间逐渐缩短,但平均值与正常组无显著差异。两组R-R间期均缩短,冠状动脉组明显大于正常组。地西泮预处理可逆转冠状动脉组的两种反应。心得安预处理可减轻冠状动脉组的心动过速效应,逆转正常组的心动过速效应,显著缩短正常组的反应时间。所使用设备的客观时间测量可能表明,冠状动脉疾病患者对精神压力的特定(反应时间)和非特定(R-R间隔)行为与正常人不同。这种行为可以通过地西泮和心得安等药物得到改善。
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