{"title":"GY II represses proliferation and metastasis and promotes apoptosis in laryngeal squamous cell carcinoma","authors":"Yunfei Bai, Ru Wang, X. Cui, Ling Feng, Q. Shi, Hongzhi Ma, M. Lian, X. Shen, Yifan Yang, Chen Tan, Jugao Fang","doi":"10.15761/icst.1000298","DOIUrl":null,"url":null,"abstract":"Traditional Chinese Medicine (TCM) has been considered to provide certain advantages in the treatment of cancer. Guben Yiliu II (GY II) has been widely used for clinical treatment of cancer in China. The current study investigated the effects of GY II on proliferation, apoptosis, invasion, and metastasis of laryngeal squamous cell carcinoma via MTT assays, Transwell assays, and flow cytometry, respectively, in Hep-2 and cells from clinical samples. Results of MTT assays revealed that GY II inhibited the growth of cells via arresting the cell cycle at G0/G1 phase. The addition of GY II significantly suppressed cell migration and invasion. Additionally, GY II treatment significantly promoted apoptosis of tumor cells. Present findings have significant implications regarding the understanding of mechanisms and targets of GY II in terms of tumors.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative cancer science and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/icst.1000298","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Traditional Chinese Medicine (TCM) has been considered to provide certain advantages in the treatment of cancer. Guben Yiliu II (GY II) has been widely used for clinical treatment of cancer in China. The current study investigated the effects of GY II on proliferation, apoptosis, invasion, and metastasis of laryngeal squamous cell carcinoma via MTT assays, Transwell assays, and flow cytometry, respectively, in Hep-2 and cells from clinical samples. Results of MTT assays revealed that GY II inhibited the growth of cells via arresting the cell cycle at G0/G1 phase. The addition of GY II significantly suppressed cell migration and invasion. Additionally, GY II treatment significantly promoted apoptosis of tumor cells. Present findings have significant implications regarding the understanding of mechanisms and targets of GY II in terms of tumors.
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