Prospects for colorectal cancer prevention targeting intestinal microbiome

Abstract

Received: January 03, 2021; Accepted: January 26, 2021; Published: January 29, 2021 It has been reported that a so-called clean colon procedure, in which all precancerous lesions, colorectal tubular adenomas / colorectal tubulovillous adenomas, are endoscopically resection treatment is extremely useful for preventing colorectal carcinogenesis and death from colorectal cancer [1-4]. The effectiveness of chemopreventive measures to take the antidiabetic drugs metformin and low-dose aspirin has also been reported [5-7]. Recently, there have been reports suggesting the involvement of intestinal microorganisms such as Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis [8-13], and there is a possibility that a strategy targeting intestinal microorganisms will be taken as future methods for preventing colorectal carcinogenesis. This review describes the prospects for new strategies on colorectal carcinogenesis prevention targeting intestinal microbiome such as F. nucleatum.