{"title":"APE1/Ref-1 with reducing activity induces mesenchymal-to-epithelial transition in TNF-α-stimulated breast cancer cells","authors":"Sunga Choi, Ki Mo Kim, Euna Choi","doi":"10.15761/icst.1000365","DOIUrl":"https://doi.org/10.15761/icst.1000365","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Namrta Choudhry, Thaddeus David Allen, Vidhula R. Ahire, Jing Zhang, Dun Yang
in the CNS and therapeutic resistance which are repetitively seen at the time of microtubule-targeting, the use of these drugs is limited [1-4]. The new generation of mitotic drugs aims for the mitotic regulatory machinery which involves the motor proteins, mitotic kinesins, or the Aurora and polo-like kinases and complexes which are expressed only at the time of cell division [2]. Research efforts are intended towards developing superior antimitotic drugs that would not be only more specific in their action but would also lessen the burden of side effects on patients. Also, because cancer cells demonstrate vast phenotypic miscellany they are characteristically responsive to phenotypic screening which would assist in translating the molecular mechanism as a therapeutic approach in treating cancer with familiar cellular phenotypes following the theory of mechanism-informed phenotypic screening.
{"title":"Exploiting mechanism-informed phenotypic screening for development of next-generation antimitotic phytochemicals","authors":"Namrta Choudhry, Thaddeus David Allen, Vidhula R. Ahire, Jing Zhang, Dun Yang","doi":"10.15761/icst.1000350","DOIUrl":"https://doi.org/10.15761/icst.1000350","url":null,"abstract":"in the CNS and therapeutic resistance which are repetitively seen at the time of microtubule-targeting, the use of these drugs is limited [1-4]. The new generation of mitotic drugs aims for the mitotic regulatory machinery which involves the motor proteins, mitotic kinesins, or the Aurora and polo-like kinases and complexes which are expressed only at the time of cell division [2]. Research efforts are intended towards developing superior antimitotic drugs that would not be only more specific in their action but would also lessen the burden of side effects on patients. Also, because cancer cells demonstrate vast phenotypic miscellany they are characteristically responsive to phenotypic screening which would assist in translating the molecular mechanism as a therapeutic approach in treating cancer with familiar cellular phenotypes following the theory of mechanism-informed phenotypic screening.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernardo G Tenorio, Isadora S Bretas, Joao PRA Bernardes, Munnah NJ Mansour, Sarah MS Napoleao, Sheyla AS Rocha, Thatiane L Sampaio, Elisiario CV Leitao, Joaquim X Silva, Marcus VS Coimbra, Edson JM Bello, Elida CGM Kanzaki, I. Kanzaki
{"title":"Putative oncogenic viruses: Some data on Brazilian subjects","authors":"Bernardo G Tenorio, Isadora S Bretas, Joao PRA Bernardes, Munnah NJ Mansour, Sarah MS Napoleao, Sheyla AS Rocha, Thatiane L Sampaio, Elisiario CV Leitao, Joaquim X Silva, Marcus VS Coimbra, Edson JM Bello, Elida CGM Kanzaki, I. Kanzaki","doi":"10.15761/icst.1000358","DOIUrl":"https://doi.org/10.15761/icst.1000358","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
proneness cancer-predisposing genes present in the population at frequencies affect cancer incidence which do not result in cancer with a high enough probability to give rise to "cancer families." gene predisposing to be associated with the gene for debrizoquine metabolism autosomal recessive for A-T2 in the heterozygous (i.e., carrier) state, Homozygotes for A-T show a rare syndrome with a fascinating variety of aspects. Patients are deficient in immune response, show progressive neurological degeneration and defects in organ maturation, and are prone to develop cancer, particularly of the cells of the immune system Ref. Their cells show spontaneous chromosomal instabilities, and there are reports of hypersensitivity to the chromosome-breaking and/or lethal effect of ionizing radiation and certain chemicals such as bleomycin, neocarzinostatin, Adriamycin, and Hoechst 33342. A further addition to this list is phorbol ester (Shiloh, Boston, MA), a tumor that been cause endogenous
{"title":"Ataxia-telangiectasia","authors":"A. Ekladious","doi":"10.15761/icst.1000359","DOIUrl":"https://doi.org/10.15761/icst.1000359","url":null,"abstract":"proneness cancer-predisposing genes present in the population at frequencies affect cancer incidence which do not result in cancer with a high enough probability to give rise to \"cancer families.\" gene predisposing to be associated with the gene for debrizoquine metabolism autosomal recessive for A-T2 in the heterozygous (i.e., carrier) state, Homozygotes for A-T show a rare syndrome with a fascinating variety of aspects. Patients are deficient in immune response, show progressive neurological degeneration and defects in organ maturation, and are prone to develop cancer, particularly of the cells of the immune system Ref. Their cells show spontaneous chromosomal instabilities, and there are reports of hypersensitivity to the chromosome-breaking and/or lethal effect of ionizing radiation and certain chemicals such as bleomycin, neocarzinostatin, Adriamycin, and Hoechst 33342. A further addition to this list is phorbol ester (Shiloh, Boston, MA), a tumor that been cause endogenous","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of low doses of verapamil on the course of Kaposi's sarcoma","authors":"Gridina Nina Yakivna","doi":"10.15761/icst.1000362","DOIUrl":"https://doi.org/10.15761/icst.1000362","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67479077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial comments to the articles published in Volume 8","authors":"H. Miyamoto","doi":"10.15761/icst.1000363","DOIUrl":"https://doi.org/10.15761/icst.1000363","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shokouh Sadat Aboutorabi, Z. Rasooli, H. Pakniat, Fahimeh Baloo
{"title":"Molecular characterization of prevalence, serotypes, virulence factors, and antibiotic resistance of Streptococcus agalactiae in a maternity hospital, Iran","authors":"Shokouh Sadat Aboutorabi, Z. Rasooli, H. Pakniat, Fahimeh Baloo","doi":"10.15761/icst.1000356","DOIUrl":"https://doi.org/10.15761/icst.1000356","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67479013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Received: January 03, 2021; Accepted: January 26, 2021; Published: January 29, 2021 It has been reported that a so-called clean colon procedure, in which all precancerous lesions, colorectal tubular adenomas / colorectal tubulovillous adenomas, are endoscopically resection treatment is extremely useful for preventing colorectal carcinogenesis and death from colorectal cancer [1-4]. The effectiveness of chemopreventive measures to take the antidiabetic drugs metformin and low-dose aspirin has also been reported [5-7]. Recently, there have been reports suggesting the involvement of intestinal microorganisms such as Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis [8-13], and there is a possibility that a strategy targeting intestinal microorganisms will be taken as future methods for preventing colorectal carcinogenesis. This review describes the prospects for new strategies on colorectal carcinogenesis prevention targeting intestinal microbiome such as F. nucleatum.
收稿日期:2021年1月03日;录用日期:2021年1月26日;据报道，所谓的清洁结肠手术，其中所有癌前病变，结肠管状腺瘤/结肠管状绒毛腺瘤，在内镜下切除治疗，对预防结直肠癌发生和结直肠癌死亡非常有用[1-4]。降糖药二甲双胍、小剂量阿司匹林等化学预防措施的有效性也有报道[5-7]。近年来，有报道表明肠内微生物如核梭杆菌(Fusobacterium nucleatum, F. nucleatum)参与结直肠癌的发生[8-13]，未来有可能采取针对肠道微生物的策略来预防结直肠癌的发生。本文综述了针对具核梭菌等肠道微生物群的结直肠癌预防新策略的研究前景。
{"title":"Prospects for colorectal cancer prevention targeting intestinal microbiome","authors":"T. Ohara","doi":"10.15761/icst.1000351","DOIUrl":"https://doi.org/10.15761/icst.1000351","url":null,"abstract":"Received: January 03, 2021; Accepted: January 26, 2021; Published: January 29, 2021 It has been reported that a so-called clean colon procedure, in which all precancerous lesions, colorectal tubular adenomas / colorectal tubulovillous adenomas, are endoscopically resection treatment is extremely useful for preventing colorectal carcinogenesis and death from colorectal cancer [1-4]. The effectiveness of chemopreventive measures to take the antidiabetic drugs metformin and low-dose aspirin has also been reported [5-7]. Recently, there have been reports suggesting the involvement of intestinal microorganisms such as Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis [8-13], and there is a possibility that a strategy targeting intestinal microorganisms will be taken as future methods for preventing colorectal carcinogenesis. This review describes the prospects for new strategies on colorectal carcinogenesis prevention targeting intestinal microbiome such as F. nucleatum.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytotherapy and oncology. A short review","authors":"A. Sannia","doi":"10.15761/icst.1000353","DOIUrl":"https://doi.org/10.15761/icst.1000353","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong-chang Li, Huan Liu, Ya-feng Chen, Jie Li, Weiyan Liu, Ke-Bin Xu, D. Feng, Xia Sheng
{"title":"Compound cantharis revers chemotherapy resistance of TNBC via miR-520d/Beclin-1 signal axis","authors":"Hong-chang Li, Huan Liu, Ya-feng Chen, Jie Li, Weiyan Liu, Ke-Bin Xu, D. Feng, Xia Sheng","doi":"10.15761/icst.1000354","DOIUrl":"https://doi.org/10.15761/icst.1000354","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67478572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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