Immunity or morphogenesis in cancer development and treatment

Abstract

Non-selective cytotoxic therapy of cancer is effective, acting harmfully for a host. Legal deep lymphocytopenia at conventional cytotoxic therapy, high risk of new malignancies after it, spreading of malignant cells through favorite lymph nodes, a restriction of immunocytes activity inside tumor at anti-angiogenic treatment does not feet the idea of host immune defense against spontaneous cancer. To understand these theoretical inconsistencies we discussed the development of a tumor and its microvessels, gradual exhaustion of hematopoietic stem cell number in blood and arising of cancer cachexia, ratio of infectious morbidity and cancer mortality in their interrelation, using an experimental, clinical data and population statistics. We concluded, that mentioned above and other principal discrepancies would become regularities, if the cells renewing in both malignant and normal tissues were taken as a result of the recently discovered morphogenesis activity of circulating mononuclear cells, originated from the bone marrow and presented by tissue’s committed stem cells and some subsets of morpho-angiogenic lymphocytes. *Correspondence to: Shoutko AN, Laboratory for Improvement of the Cancer Treatment Methods, Russian Granov’s Research Center for Radiology and Surgical Technologies, Ministry of Health Care of the Russian Federation, SaintPetersburg, Russia, E-mail: shoutko@inbox.ru