{"title":"Hydroxyindole O-methyltransferase controls cancer growth and metastasis","authors":"Kenneth K. Wu","doi":"10.15761/icst.1000330","DOIUrl":null,"url":null,"abstract":"conversion of to (5-HTP) and O-methyltransferase (HIOMT) which transfer of methyl group from a methyl donor to 5-HTP to form 5-MTP. very low level of 5-MTP due to expression of HIOMT. of HIOMT by stable transfection of a HIOMT isoform (HIOMT in 5-MTP production accompanied by reduced cancer cell migration in vitro and slower tumor growth and fewer lung metastatic nodules in a murine tumor model the isoforms which catalyze 5-MTP vs. melatonin biosynthesis.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative cancer science and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/icst.1000330","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
conversion of to (5-HTP) and O-methyltransferase (HIOMT) which transfer of methyl group from a methyl donor to 5-HTP to form 5-MTP. very low level of 5-MTP due to expression of HIOMT. of HIOMT by stable transfection of a HIOMT isoform (HIOMT in 5-MTP production accompanied by reduced cancer cell migration in vitro and slower tumor growth and fewer lung metastatic nodules in a murine tumor model the isoforms which catalyze 5-MTP vs. melatonin biosynthesis.
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