Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis

Abstract

Background: Peri-implantitis is an infectious disease around dental implants characterized by inflammation of the peri-implant connective tissues and progressive loss of supporting bone, with an estimated prevalence of around 22%. Peri-implantitis microbiota is different from that observed in both periodontitis and healthy implants. Knowledge of this microbiota is crucial for the proper treatment of the disease. Objective: To assess the differences in the oral microbiota in dental implant-bearing patients with and without peri-implantitis. Methods: A search for studies on microbiota and peri-implantitis up to June 2021 was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science, Scopus, ProQuest, LILACS, and Google Scholar. For dichotomous outcomes, the effects of the intervention were expressed as odds ratios (OR) using Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: Twelve studies with 1324 participants were included in this meta-analysis. Peri-implantitis patients were more likely to be carriers of the following microorganisms: Tannerella forsythia (OR=3.17, 95% CI: 1.55 to 6.51, P<0.01); Prevotella intermedia (OR=2.21, 95% CI: 1.73 to 2.82, P<0.001); Treponema denticola (OR=2.18, 95% CI: 1.70 to 2.79, P<0.001); Porphyromonas gingivalis (OR=2.04, 95% CI: 1.16 to 3.59, P=0.01); Fusobacterium nucleatum (OR=1.81, 95% CI: 1.21 to 2.72, P<0.01), and Campylobacter rectus (OR=1.69, 95% CI: 1.32 to 2.17, P<0.001). In contrast, the bacteria Aggregatibacter actinomycetemcomitans and Streptococcus mitis were more prevalent in peri-implantitis patients but not significantly (P>0.05). Conclusion: Peri-implantitis modifies the quantitative and qualitative composition of the oral microbiota.