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The Inflammatory Markers C-reactive Protein and Mean Platelet Volume in Chronic Kidney Disease 慢性肾脏疾病的炎症标志物c反应蛋白和平均血小板体积
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.1
İ. Kılıç, Elif Tuğba Oğuz Taylan, İ. Kurultak, S. Üstündağ
Background: People with chronic kidney disease (CKD) experience chronic systemic inflammation. Although a relationship exists between inflammation and renal injury, the association between inflammatory markers and renal disease has not been well-studied. As inflammation may be a trigger or a result of chronic disease, the kidney needs to be investigated to determine whether it is a clearer target for the devastating effects of persistent inflammation. Here, we report the relation of C-reactive protein and mean platelet volume levels with renal functions in chronic kidney disease patients. Methods: This study was an observational retrospective single-center study conducted on the record of CKD patients to detect the outcomes over a median follow-up time of three years. Demographic, clinical, laboratory, medication, and outcome data were obtained from the electronic data records of the hospital. We investigated the multivariable association of plasma levels of C-reactive protein and mean platelet volume with the progression of CKD in the study participants. Findings: Elevated plasma levels of C-reactive protein (r=0.13, P<0.001) and mean platelet volume (r=0.23, P<0.001) were associated with a greater loss of kidney function over time. The presence of diabetes mellitus was detected to be a risk factor for CKD progression (P=0.04). An inverse relationship was detected between sodium and creatinine (P<0.001). In addition, a weak association was detected between uric acid and creatinine (P<0.001). Conclusion: Elevated plasma levels of C-reactive protein and mean platelet volume were associated with a decline in the estimated glomerular filtration rate in patients with CKD.
背景:慢性肾脏疾病(CKD)患者经历慢性全身性炎症。虽然炎症与肾损伤之间存在关系,但炎症标志物与肾脏疾病之间的关系尚未得到充分研究。由于炎症可能是慢性疾病的触发因素,也可能是慢性疾病的结果,因此需要对肾脏进行研究,以确定它是否是持久炎症破坏性影响的更明确目标。在这里,我们报告了慢性肾病患者c反应蛋白和平均血小板体积水平与肾功能的关系。方法:本研究是一项观察性回顾性单中心研究,对CKD患者进行记录,以检测中位随访时间为三年的结果。人口统计、临床、实验室、用药和结局数据均来自医院的电子数据记录。我们研究了研究参与者血浆c反应蛋白水平和平均血小板体积与CKD进展的多变量关联。结果:随着时间的推移,血浆c反应蛋白水平升高(r=0.13, P<0.001)和平均血小板体积升高(r=0.23, P<0.001)与肾功能的严重丧失相关。糖尿病的存在是CKD进展的危险因素(P=0.04)。钠与肌酐呈负相关(P<0.001)。此外,在尿酸和肌酐之间检测到弱关联(P<0.001)。结论:血浆c反应蛋白水平和平均血小板体积升高与CKD患者肾小球滤过率下降有关。
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引用次数: 0
Humic and Fulvic Acids Induced Thermodynamic and Structural Instability of Tyrosinase With Antiproliferative Effect on A375 Melanoma Cancer Cell Line 腐植酸和黄腐酸诱导酪氨酸酶的热力学和结构不稳定性对A375黑色素瘤癌细胞的抗增殖作用
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.3
Negar Taherkhani, Hossein Piri, A. Hekmat, K. Haghbeen
Background: The tyrosinase enzyme catalysis monophenols to melanin pigments through the melanogenesis process. For this reason, various inhibitors have been studied for enzyme regulations in melanogenesis abnormalities in both the food and cosmetics industries. In this study, the effect of humic acid (Hu) and fulvic acid (Fu) on the structure, activity, and stability of mushroom tyrosinase (MT) was investigated. Methods: These two organic acids are the main components of soil humus. Assessment of the thermodynamic and structural stability of enzymes was obtained through thechemical and thermal denaturations and (8-anilino-naphthalene sulfonic acid) ANS fluorescence analysis. The Hu and Fu impact on A375 melanoma cancer cell viability was achieved by MTT assay. Findings: The results of enzyme half denaturation concentration (Cm), melting points (Tm), ΔG0 values and external fluorescence emissions in the presence of Hu and FA proved the reduction of the thermodynamic and structural stability of MT by these compounds. The anti-proliferation effects of the compounds were confirmed by the inhibitory concentrations of 50% (IC50) of 31.5 and 42.7 µM and 12.5 and µM at time points of 24 and 48 hours treatments of the A375 melanoma cell line by Hu and Fu, respectively. Conclusion: Humic and fulvic acids can be expected to contribute to advancing skin disorder science play a crucial role in tyrosinase related disorders and anti-cancer effects, and good candidates for medical applications.
背景:酪氨酸酶通过黑色素形成过程催化单酚类物质生成黑色素。因此,在食品和化妆品行业中,人们研究了各种抑制剂对黑色素生成异常的酶调节。本研究研究了腐植酸(Hu)和黄腐酸(Fu)对蘑菇酪氨酸酶(MT)结构、活性和稳定性的影响。方法:这两种有机酸是土壤腐殖质的主要成分。通过化学变性和热变性以及(8-苯胺-萘磺酸)ANS荧光分析对酶的热力学和结构稳定性进行了评价。通过MTT法测定Hu和Fu对A375黑色素瘤癌细胞活力的影响。结果:酶半变性浓度(Cm)、熔点(Tm)、ΔG0值和在Hu和FA存在下的外部荧光发射结果证明,这些化合物降低了MT的热力学和结构稳定性。通过Hu和Fu对A375黑色素瘤细胞系处理24和48小时时,31.5和42.7µM、12.5和µM的抑制浓度分别为50% (IC50),证实了化合物的抗增殖作用。结论:腐植酸和黄腐酸有望推动皮肤病科学的发展,在酪氨酸酶相关疾病和抗癌方面发挥重要作用,具有良好的医学应用前景。
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引用次数: 0
The Relationship Between the Full Biophysical Profile and Rapid Biophysical Profile in Antepartum Fetal Surveillance 产前胎儿监测中全生物物理特征与快速生物物理特征的关系
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.4
H. Pakniat, Ezzatalsadat Haji Seid Javadi, Venus Chegini, Nahid Khajevand, Simindokht Molaverdikhani
Background: One of the best tests for the assessment of a fetus is the biophysical profile test which has a significant effect on the fetus’s health and the outcome of pregnancy. The present study was designed to determine the relationship between the full biophysical profile (FBP) and the rapid biophysical profile (RBP) tests in antepartum fetal surveillance. Methods: In this prospective study, Singleton pregnancies (n=209) with more than 34 weeks of gestational age were chosen. Both FBP and RBP tests were performed for all the patients. The main outcome is the Apgar score and neonatal intensive care unit admission analyzed by SPSS software, version 24. The sensitivity, specificity, positive predictive value, and negative predictive value of RBP were calculated. Findings: Out of 209 people who entered the study, 48 women (23.0%) had gestational diabetes, 84 women (40.2%) had hypertension pregnancy (preeclampsia), 45 people (21.5%) had intrauterine growth restriction, and 45 women (21.5%) had post-date pregnancy. For predicting adverse fetal outcomes of pregnancy, the sensitivity, specificity, positive predictive value, and negative predictive value of RBP were 95%, 73%, 52%, and 98%, respectively. Conclusion: According to the statistically significant positive correlation between RBP and FBP and its simple and rapid application, RBP might be an acceptable alternative method for primary antepartum fetal screening tests in overcrowded obstetrics centers.
背景:生物体格检查是评估胎儿的最佳检查之一,它对胎儿的健康和妊娠结局有重要影响。本研究旨在确定全生物物理特征(FBP)和快速生物物理特征(RBP)试验在产前胎儿监测中的关系。方法:在这项前瞻性研究中,选择胎龄大于34周的单胎妊娠(n=209)。所有患者均行FBP和RBP试验。主要观察指标为Apgar评分和新生儿重症监护病房入住情况,采用SPSS软件进行分析。计算RBP的敏感性、特异性、阳性预测值和阴性预测值。结果:在209名参与研究的女性中,48名女性(23.0%)患有妊娠糖尿病,84名女性(40.2%)患有高血压妊娠(先兆子痫),45名女性(21.5%)患有宫内生长受限,45名女性(21.5%)患有产后妊娠。预测妊娠不良胎儿结局,RBP的敏感性为95%,特异性为73%,阳性预测值为52%,阴性预测值为98%。结论:RBP与FBP呈正相关,且应用简便、快速,可作为拥挤产科中心产前胎儿筛查的一种可接受的替代方法。
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引用次数: 0
Dyschloremia During Severe COVID‑19 Infection in Intensive Care Unit Patients 重症监护病房患者重症COVID - 19感染期间的精神障碍者
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.5
Maryam Gheraati, M. Mirzadeh, Fatemeh Nazifi, Negar Sheikhdavoodi, Atefeh Khoshkchali
Background: Dyschloremia is one of the most prevalent abnormalities that is highly associated with a high level of mortality in intensive care unit (ICU) patients. The current study evaluated serum chloride levels in COVID-19 patients hospitalized in the ICU. Methods: This cross-sectional study was conducted on 245 patients with severe COVID-19 who were admitted to the intensive care unit (ICU). Electrolytes, albumin, liver function test, complete blood count, serum chloride, and VBG were among the laboratory markers compared. The Chi-square, t-test, and logistic regression models were used to examine the relationship between these markers and the key outcomes, which included severity, mortality, intubation, and hospitalization. Findings: The Mean±SD age of patients was 58.16±17 years. The mean serum chloride level in the studied patients was 109.6±5.1 with a range of 100-134. According to the regression logistic model, variables like age, intubation status, pH, and chlorine levels significantly affected the outcome of COVID-19 disease. Patients with acidosis were 4.7 times more likely to die than those with alkalosis (P<0.001). The chance of dying in hyperchloremia is 2.38 times more compared to the normochloremia group (P<0.009). Conclusion: Patients with severe COVID-19 may present with chlorine abnormalities, including hyperchloremia. Hyperchloremia is also associated with poor clinical outcomes and a higher mortality risk. This relationship was independent of acid-base disorder.
背景:在重症监护病房(ICU)患者中,精神障碍性贫血是最普遍的异常之一,与高死亡率高度相关。目前的研究评估了在ICU住院的COVID-19患者的血清氯化物水平。方法:对245例重症监护病房(ICU)重症COVID-19患者进行横断面研究。电解质、白蛋白、肝功能、全血细胞计数、血清氯化物和VBG是比较的实验室指标。使用卡方检验、t检验和逻辑回归模型来检验这些标志物与关键结局(包括严重程度、死亡率、插管和住院)之间的关系。结果:患者平均±SD年龄为58.16±17岁。研究患者的平均血氯水平为109.6±5.1,范围为100-134。根据回归logistic模型,年龄、插管状态、pH、氯浓度等变量显著影响COVID-19疾病的预后。酸中毒患者的死亡率是碱中毒患者的4.7倍(P<0.001)。高氯血症组的死亡率是正常氯血症组的2.38倍(P<0.009)。结论:重症COVID-19患者可能存在氯异常,包括高氯血症。高氯血症还与较差的临床结果和较高的死亡风险相关。这种关系与酸碱紊乱无关。
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引用次数: 0
Effect of Antioxidant on Sperm Freezing 抗氧化剂对精子冷冻的影响
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.7
Maryam Zamani, Fariba Zafari, Vahid Najafzadeh, Farzad Rajaei, Mana Kamranjam, Amir Hosseini
A major cause of male infertility, which includes 50 causes of infertility, is oxidative stress. Aerobic respiration in the sperm cell is associated with the production of reactive oxygen species (ROS). Some reactions, such as sperm capacitation and acrosome reactions require moderate levels of ROS. However, when the amount of ROS production surpasses the natural antioxidant defense of the cell, it causes a harmful effect called oxidative stress. This results in the oxidation of lipids, proteins, carbohydrates, and nucleotides. The production of ROS is increased by various factors, including the presence of leukocytes, sperms with abnormal and immature morphology, centrifugation of samples, and changes in oxygen concentration, pH, and temperature. Sperm freezing is a method widely used in assisted reproductive technology (ART) as well as infertility treatment. The process of freezing also contributes to increased oxidative stress because it alters the fluidity of the mitochondrial membrane, leading to increased production and release of ROS. Sperm have defense mechanisms against oxidative stress caused by increased ROS production, which includes the presence of enzymatic and non-enzymatic antioxidants in semen. The utilization of supplementary antioxidants in the freezing environment is a strategy to combat oxidative stress. This review aims to summarize the current evidence on the effect of antioxidants on sperm freezing.
男性不育的一个主要原因是氧化应激,其中包括50种不育原因。精子细胞中的有氧呼吸与活性氧(ROS)的产生有关。一些反应,如精子获能和顶体反应需要适度水平的ROS。然而,当活性氧产生的数量超过细胞的天然抗氧化防御时,它会引起一种叫做氧化应激的有害影响。这会导致脂质、蛋白质、碳水化合物和核苷酸的氧化。ROS的产生受多种因素的影响,包括白细胞的存在、形态异常和不成熟的精子、样品的离心、氧浓度、pH和温度的变化。精子冷冻是一种广泛应用于辅助生殖技术(ART)和不孕症治疗的方法。冷冻过程也会增加氧化应激,因为它改变了线粒体膜的流动性,导致活性氧的产生和释放增加。精子具有防御由活性氧增加引起的氧化应激的机制,包括精液中酶促和非酶促抗氧化剂的存在。在冰冻环境中补充抗氧化剂的利用是对抗氧化应激的一种策略。本文综述了抗氧化剂对精子冷冻影响的最新研究进展。
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引用次数: 0
Immunophenotyping of Childhood Acute Lymphoblastic Leukemia in Qazvin City, Iran: A Cross-Sectional Study 伊朗Qazvin市儿童急性淋巴细胞白血病的免疫分型:一项横断面研究
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.6
Majid Vafaie, Mohammad Derhami, Hamid Sadeghi, Saeideh Gholamzadeh Khoei
Background: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer. ALL is a heterogeneous type of malignancy and treatment protocols vary based on the immunological classification of ALL. The critical step for treating ALL is to identify immunological subgroups by flow cytometry findings. Objective: In this study, immunophenotypic information was evaluated for the first time in children with ALL in Qazvin City, Iran. Methods: This cross-sectional study reviewed the clinical and laboratory data of children with ALL during 2019-2020. Next, children with ALL were immunophenotyped by flow cytometry applying a panel of the specific monoclonal antibodies for some clusters of differentiation (CD) molecules, including CD20, CD21, CD10, CD34, CD38, and terminal deoxynucleotidyl transferase (TdT). The data were separately analyzed using SPSS software, version 24. Findings: Of 52 children with ALL in the age range of 6 months to 15 years, 23 children (44.23%) had B-ALL-ProB (pro-B) cell immunotyping features, 26 (50%) had B-ALL-PreB (pre-B) cell immunotyping features, and 3 (5.7%) had T-cell immunotyping features. The ages of T-cell group children were higher than those of B-cell group children. The most common clinical and laboratory findings were fever (26 cases, 55.31%). In 55% of children, periodic acid-schiff (PAS) staining was positive. The presence of the terminal deoxynucleotidyl transferase (TdT) enzyme was higher in B-cell patients than in T-cell cases. Children with CD34+ were higher in the pro-B group than in the pre-B group. Conclusion: our study shows that the immunophenotypic characteristics of children with ALL are more similar to previous reports and can be used for monitoring and prognosis of children with ALL in Qazvin City.
背景:急性淋巴细胞白血病(ALL)是最常见的儿童癌症。ALL是一种异质性恶性肿瘤,治疗方案因ALL的免疫学分类而异。治疗急性淋巴细胞白血病的关键一步是通过流式细胞术的发现来确定免疫亚群。目的:在这项研究中,首次评估伊朗Qazvin市ALL儿童的免疫表型信息。方法:本横断面研究回顾了2019-2020年ALL患儿的临床和实验室资料。接下来,用流式细胞术对ALL患儿进行免疫分型,使用一组针对某些分化(CD)分子簇的特异性单克隆抗体,包括CD20、CD21、CD10、CD34、CD38和末端脱氧核苷酸转移酶(TdT)。数据分别用SPSS软件24版进行分析。结果:52例6个月~ 15岁ALL患儿中,23例(44.23%)患儿具有B-ALL-ProB(前b)细胞免疫分型特征,26例(50%)患儿具有B-ALL-PreB(前b)细胞免疫分型特征,3例(5.7%)患儿具有t细胞免疫分型特征。t细胞组患儿年龄明显高于b细胞组患儿。最常见的临床和实验室表现为发热(26例,占55.31%)。55%的儿童周期性酸希夫(PAS)染色呈阳性。末端脱氧核苷酸转移酶(TdT)酶在b细胞患者中的存在高于t细胞患者。CD34+患儿在前b组高于前b组。结论:我们的研究表明,ALL患儿的免疫表型特征与以往报道更为相似,可用于Qazvin市ALL患儿的监测和预后。
{"title":"Immunophenotyping of Childhood Acute Lymphoblastic Leukemia in Qazvin City, Iran: A Cross-Sectional Study","authors":"Majid Vafaie, Mohammad Derhami, Hamid Sadeghi, Saeideh Gholamzadeh Khoei","doi":"10.32598/jid.26.4.6","DOIUrl":"https://doi.org/10.32598/jid.26.4.6","url":null,"abstract":"Background: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer. ALL is a heterogeneous type of malignancy and treatment protocols vary based on the immunological classification of ALL. The critical step for treating ALL is to identify immunological subgroups by flow cytometry findings. Objective: In this study, immunophenotypic information was evaluated for the first time in children with ALL in Qazvin City, Iran. Methods: This cross-sectional study reviewed the clinical and laboratory data of children with ALL during 2019-2020. Next, children with ALL were immunophenotyped by flow cytometry applying a panel of the specific monoclonal antibodies for some clusters of differentiation (CD) molecules, including CD20, CD21, CD10, CD34, CD38, and terminal deoxynucleotidyl transferase (TdT). The data were separately analyzed using SPSS software, version 24. Findings: Of 52 children with ALL in the age range of 6 months to 15 years, 23 children (44.23%) had B-ALL-ProB (pro-B) cell immunotyping features, 26 (50%) had B-ALL-PreB (pre-B) cell immunotyping features, and 3 (5.7%) had T-cell immunotyping features. The ages of T-cell group children were higher than those of B-cell group children. The most common clinical and laboratory findings were fever (26 cases, 55.31%). In 55% of children, periodic acid-schiff (PAS) staining was positive. The presence of the terminal deoxynucleotidyl transferase (TdT) enzyme was higher in B-cell patients than in T-cell cases. Children with CD34+ were higher in the pro-B group than in the pre-B group. Conclusion: our study shows that the immunophenotypic characteristics of children with ALL are more similar to previous reports and can be used for monitoring and prognosis of children with ALL in Qazvin City.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"67 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73551379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Remdesivir as An Anti-COVID-19 Drug on the Secretion of Inflammatory Markers by Chicken Liver Cells: An In Vitro Study 瑞德西韦抗covid -19药物对鸡肝细胞分泌炎症标志物的影响
Pub Date : 2023-01-01 DOI: 10.32598/jid.26.4.2
Zahra Akbari Jonoush, Roya Mahdavi, M. Ghafourian, S. Khoshnam, Fereshteh Nezhad Dehbashi, Maryam Farzaneh
Background: For severe cases of acute respiratory syndrome type 2 (SARS-CoV-2) infection (COVID-19), Remdesivir (RDV) is introduced as an anti-viral drug with side effects. Hepatotoxicity from prolonged exposure to RDV is associated with increased inflammatory factors. In this study, we evaluated the effect of RDV on the secretion of inflammatory markers by chicken liver cells. Methods: In this in vitro study, 20 stage X embryonated chicken eggs were incubated for 10 days at 37.5°C and 60–65% humidity Hamburger–Hamilton stages (stage HH35). Liver cells were grown in a medium containing DMEM/F12+10% fetal bovine serum (FBS). After three days, the culture media was supplemented with four doses of RDV (1.00, 2.00, 3.00, and 4.00 μM). After 24 and 48hs, the viability of the hepatocytes, gene expression of Sox17, CXC motif chemokine receptor 4 (CXCR4), Interleukin-1 (IL-1), Interleukin-6 (IL-6), and TNF-α, and hepatocellular functions (albumin and urea secretion) were assessed. Findings: Each hepatocyte had a prominent nucleus and a nucleolus with a hexagonal shape. The pink tint of the periodic acid Schiff (PAS) positive cells in the PAS staining verified the hepatocytes’ glycogen content. Up to 50% of the cells lose viability after 48 hours in the presence of 3 and 4 μM RDV (P<0.001). In the presence of 3 μM RDV, the production and secretion of both albumin (P<0.001) and urea (P<0.05) decreased. Besides, the expression of IL-1, IL-6, and TNF-α significantly increased after treatment with 3 μM RDV (P<0.001). Conclusion: We concluded that RDV therapy altered the expression and function of hepatocyte inflammatory factors.
背景:对于严重的急性呼吸综合征2型(SARS-CoV-2)感染(COVID-19)病例,瑞德西韦(Remdesivir, RDV)作为一种有副作用的抗病毒药物被引入。长期暴露于RDV的肝毒性与炎症因子增加有关。在本研究中,我们评估了RDV对鸡肝细胞炎症标志物分泌的影响。方法:采用20只X期鸡胚,在37.5℃、60-65%湿度条件下培养10 d (HH35期)。肝细胞在含有DMEM/F12+10%胎牛血清(FBS)的培养基中生长。3 d后,在培养基中添加4个剂量(1.00、2.00、3.00、4.00 μM)的RDV。24和48h后,观察肝细胞活力、Sox17、CXC基序趋化因子受体4 (CXCR4)、白细胞介素-1 (IL-1)、白细胞介素-6 (IL-6)、TNF-α基因表达及肝细胞功能(白蛋白和尿素分泌)。结果:每个肝细胞有一个突出的细胞核和一个六边形的核仁。PAS染色中周期性酸性席夫(PAS)阳性细胞呈粉红色,证实肝细胞的糖原含量。3 μM RDV和4 μM RDV作用48 h后,50%以上的细胞失去活力(P<0.001)。在3 μM RDV存在下,白蛋白(P<0.001)和尿素(P<0.05)的产生和分泌均减少。3 μM RDV处理后,IL-1、IL-6、TNF-α的表达均显著升高(P<0.001)。结论:RDV治疗可改变肝细胞炎性因子的表达和功能。
{"title":"The Effect of Remdesivir as An Anti-COVID-19 Drug on the Secretion of Inflammatory Markers by Chicken Liver Cells: An In Vitro Study","authors":"Zahra Akbari Jonoush, Roya Mahdavi, M. Ghafourian, S. Khoshnam, Fereshteh Nezhad Dehbashi, Maryam Farzaneh","doi":"10.32598/jid.26.4.2","DOIUrl":"https://doi.org/10.32598/jid.26.4.2","url":null,"abstract":"Background: For severe cases of acute respiratory syndrome type 2 (SARS-CoV-2) infection (COVID-19), Remdesivir (RDV) is introduced as an anti-viral drug with side effects. Hepatotoxicity from prolonged exposure to RDV is associated with increased inflammatory factors. In this study, we evaluated the effect of RDV on the secretion of inflammatory markers by chicken liver cells. Methods: In this in vitro study, 20 stage X embryonated chicken eggs were incubated for 10 days at 37.5°C and 60–65% humidity Hamburger–Hamilton stages (stage HH35). Liver cells were grown in a medium containing DMEM/F12+10% fetal bovine serum (FBS). After three days, the culture media was supplemented with four doses of RDV (1.00, 2.00, 3.00, and 4.00 μM). After 24 and 48hs, the viability of the hepatocytes, gene expression of Sox17, CXC motif chemokine receptor 4 (CXCR4), Interleukin-1 (IL-1), Interleukin-6 (IL-6), and TNF-α, and hepatocellular functions (albumin and urea secretion) were assessed. Findings: Each hepatocyte had a prominent nucleus and a nucleolus with a hexagonal shape. The pink tint of the periodic acid Schiff (PAS) positive cells in the PAS staining verified the hepatocytes’ glycogen content. Up to 50% of the cells lose viability after 48 hours in the presence of 3 and 4 μM RDV (P<0.001). In the presence of 3 μM RDV, the production and secretion of both albumin (P<0.001) and urea (P<0.05) decreased. Besides, the expression of IL-1, IL-6, and TNF-α significantly increased after treatment with 3 μM RDV (P<0.001). Conclusion: We concluded that RDV therapy altered the expression and function of hepatocyte inflammatory factors.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85861615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis 种植体周围炎引起的口腔微生物群变化:一项荟萃分析
Pub Date : 2022-12-01 DOI: 10.32598/jid.25.4.1
A. Rodríguez-Archilla, Barbara Palma-Casiano
Background: Peri-implantitis is an infectious disease around dental implants characterized by inflammation of the peri-implant connective tissues and progressive loss of supporting bone, with an estimated prevalence of around 22%. Peri-implantitis microbiota is different from that observed in both periodontitis and healthy implants. Knowledge of this microbiota is crucial for the proper treatment of the disease. Objective: To assess the differences in the oral microbiota in dental implant-bearing patients with and without peri-implantitis. Methods: A search for studies on microbiota and peri-implantitis up to June 2021 was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science, Scopus, ProQuest, LILACS, and Google Scholar. For dichotomous outcomes, the effects of the intervention were expressed as odds ratios (OR) using Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: Twelve studies with 1324 participants were included in this meta-analysis. Peri-implantitis patients were more likely to be carriers of the following microorganisms: Tannerella forsythia (OR=3.17, 95% CI: 1.55 to 6.51, P<0.01); Prevotella intermedia (OR=2.21, 95% CI: 1.73 to 2.82, P<0.001); Treponema denticola (OR=2.18, 95% CI: 1.70 to 2.79, P<0.001); Porphyromonas gingivalis (OR=2.04, 95% CI: 1.16 to 3.59, P=0.01); Fusobacterium nucleatum (OR=1.81, 95% CI: 1.21 to 2.72, P<0.01), and Campylobacter rectus (OR=1.69, 95% CI: 1.32 to 2.17, P<0.001). In contrast, the bacteria Aggregatibacter actinomycetemcomitans and Streptococcus mitis were more prevalent in peri-implantitis patients but not significantly (P>0.05). Conclusion: Peri-implantitis modifies the quantitative and qualitative composition of the oral microbiota.
背景:种植体周围炎是一种围绕种植体的感染性疾病,其特征是种植体周围结缔组织的炎症和支撑骨的进行性损失,估计患病率约为22%。种植体周围的微生物群不同于牙周炎和健康种植体。了解这种微生物群对正确治疗这种疾病至关重要。目的:探讨种植体周围炎患者与非种植体炎患者口腔微生物群的差异。方法:在PubMed (MEDLINE, Cochrane Library)、Web of Science、Scopus、ProQuest、LILACS和Google Scholar等数据库中检索截至2021年6月有关微生物群和种植体周围炎的研究。对于二分类结果,使用Mantel-Haenszel (M-H)方法以95%置信区间的优势比(OR)表示干预的效果。结果:本荟萃分析纳入了12项研究,共1324名受试者。种植体周围炎患者更容易携带以下微生物:单宁菌连体(OR=3.17, 95% CI: 1.55 ~ 6.51, P0.05)。结论:种植体周围炎改变了口腔微生物群的定量和定性组成。
{"title":"Changes in the Oral Microbiota Induced by Peri-implantitis: A Meta-Analysis","authors":"A. Rodríguez-Archilla, Barbara Palma-Casiano","doi":"10.32598/jid.25.4.1","DOIUrl":"https://doi.org/10.32598/jid.25.4.1","url":null,"abstract":"Background: Peri-implantitis is an infectious disease around dental implants characterized by inflammation of the peri-implant connective tissues and progressive loss of supporting bone, with an estimated prevalence of around 22%. Peri-implantitis microbiota is different from that observed in both periodontitis and healthy implants. Knowledge of this microbiota is crucial for the proper treatment of the disease. Objective: To assess the differences in the oral microbiota in dental implant-bearing patients with and without peri-implantitis. Methods: A search for studies on microbiota and peri-implantitis up to June 2021 was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science, Scopus, ProQuest, LILACS, and Google Scholar. For dichotomous outcomes, the effects of the intervention were expressed as odds ratios (OR) using Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: Twelve studies with 1324 participants were included in this meta-analysis. Peri-implantitis patients were more likely to be carriers of the following microorganisms: Tannerella forsythia (OR=3.17, 95% CI: 1.55 to 6.51, P<0.01); Prevotella intermedia (OR=2.21, 95% CI: 1.73 to 2.82, P<0.001); Treponema denticola (OR=2.18, 95% CI: 1.70 to 2.79, P<0.001); Porphyromonas gingivalis (OR=2.04, 95% CI: 1.16 to 3.59, P=0.01); Fusobacterium nucleatum (OR=1.81, 95% CI: 1.21 to 2.72, P<0.01), and Campylobacter rectus (OR=1.69, 95% CI: 1.32 to 2.17, P<0.001). In contrast, the bacteria Aggregatibacter actinomycetemcomitans and Streptococcus mitis were more prevalent in peri-implantitis patients but not significantly (P>0.05). Conclusion: Peri-implantitis modifies the quantitative and qualitative composition of the oral microbiota.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81551870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence of Anti-SARS-CoV-2 IgG Antibody in Healthcare Workers: A Report From Rafsanjan City 拉夫桑詹市卫生工作者抗sars - cov -2 IgG抗体血清阳性率报告
Pub Date : 2022-12-01 DOI: 10.32598/jid.25.4.4
M. Tashakori, A. Jamalizadeh, M. Nejad-Ghaderi, M. Hadavi, Aliakbar Yousefi-Ahmadipour, Fateme Mohseni Moghadam, Athareh Soresrafil, Kazem Mashayekhi
Background: Healthcare workers (HCWs) have a high risk of catching SARS-CoV-2 infection. Seroprevalence studies can provide related data on HCWs with a history of infections. Despite numerous seroepidemiological reports of COVID-19 in different groups, there are no such reports for HCWs working in Rafsanjan City, Iran. This study aimed to determine the SARS-CoV-2 seroprevalence among HCWs. Methods: Blood samples were obtained from 295 participants, including healthcare personnel and administrative staff. The SARS-CoV-2 IgG antibody was measured by the ELISA method, and the obtained data were analyzed with the Chi-square test and logistic regression. A P<0.05 was considered statistically significant. Results: The previous exposure to COVID-19 was higher in HCWs than in administrative department staff. Fifteen out of 130 (11.5%) participants had experienced SARS-CoV-2 infection without any symptoms. The results of logistic regression indicated that traveling (OR: 018, 95% CI: 0.08–0.74, P=0.001), occupation (OR: 0.2, 95% CI: 0.01–0.94, P<0.05), history of respiratory problems (OR: 0.15, 95% CI: 0.01–1.94, P<0.05), and major clinical signs (OR: 8.09, 95% CI: 3.7-17.66, P<0.001) are important factors which affect SARS-CoV-2 IgG antibodies. Conclusion: Our results indicated an occupational risk for SARS-CoV-2 infection among HCWs. Because some HCWs are asymptomatic, their communication, such as traveling, must be controlled, and it is necessary to ensure the safety of HCWs and reduce their transfer to the community and patients.
背景:卫生保健工作者是感染SARS-CoV-2的高危人群。血清患病率研究可为有感染史的卫生保健工作者提供相关数据。尽管在不同人群中有许多COVID-19血清流行病学报告,但在伊朗拉夫桑詹市工作的卫生保健工作者没有此类报告。本研究旨在确定医护人员中SARS-CoV-2的血清阳性率。方法:对295名医务人员和行政人员进行血样采集。采用ELISA法检测SARS-CoV-2 IgG抗体,所得数据采用卡方检验和logistic回归分析。P<0.05为差异有统计学意义。结果:卫生保健工作者的既往接触率高于行政部门工作人员。130名参与者中有15名(11.5%)经历了SARS-CoV-2感染,但没有任何症状。logistic回归结果显示,旅行(OR: 018, 95% CI: 0.08 ~ 0.74, P=0.001)、职业(OR: 0.2, 95% CI: 0.01 ~ 0.94, P<0.05)、呼吸系统病史(OR: 0.15, 95% CI: 0.01 ~ 1.94, P<0.05)、主要临床症状(OR: 8.09, 95% CI: 3.7 ~ 17.66, P<0.001)是影响SARS-CoV-2 IgG抗体的重要因素。结论:卫生保健工作者存在感染SARS-CoV-2的职业风险。由于部分医护人员无症状,必须控制其出行等交流,确保医护人员安全,减少向社区和患者转移。
{"title":"Seroprevalence of Anti-SARS-CoV-2 IgG Antibody in Healthcare Workers: A Report From Rafsanjan City","authors":"M. Tashakori, A. Jamalizadeh, M. Nejad-Ghaderi, M. Hadavi, Aliakbar Yousefi-Ahmadipour, Fateme Mohseni Moghadam, Athareh Soresrafil, Kazem Mashayekhi","doi":"10.32598/jid.25.4.4","DOIUrl":"https://doi.org/10.32598/jid.25.4.4","url":null,"abstract":"Background: Healthcare workers (HCWs) have a high risk of catching SARS-CoV-2 infection. Seroprevalence studies can provide related data on HCWs with a history of infections. Despite numerous seroepidemiological reports of COVID-19 in different groups, there are no such reports for HCWs working in Rafsanjan City, Iran. This study aimed to determine the SARS-CoV-2 seroprevalence among HCWs. Methods: Blood samples were obtained from 295 participants, including healthcare personnel and administrative staff. The SARS-CoV-2 IgG antibody was measured by the ELISA method, and the obtained data were analyzed with the Chi-square test and logistic regression. A P<0.05 was considered statistically significant. Results: The previous exposure to COVID-19 was higher in HCWs than in administrative department staff. Fifteen out of 130 (11.5%) participants had experienced SARS-CoV-2 infection without any symptoms. The results of logistic regression indicated that traveling (OR: 018, 95% CI: 0.08–0.74, P=0.001), occupation (OR: 0.2, 95% CI: 0.01–0.94, P<0.05), history of respiratory problems (OR: 0.15, 95% CI: 0.01–1.94, P<0.05), and major clinical signs (OR: 8.09, 95% CI: 3.7-17.66, P<0.001) are important factors which affect SARS-CoV-2 IgG antibodies. Conclusion: Our results indicated an occupational risk for SARS-CoV-2 infection among HCWs. Because some HCWs are asymptomatic, their communication, such as traveling, must be controlled, and it is necessary to ensure the safety of HCWs and reduce their transfer to the community and patients.","PeriodicalId":91544,"journal":{"name":"Journal of inflammatory bowel diseases & disorders","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88307606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying the Effective Factors in the Death of Patients Receiving Convalescent Plasma 康复期血浆患者死亡的影响因素分析
Pub Date : 2022-12-01 DOI: 10.32598/jid.25.4.7
Leyli Yekefallah, P. Namdar, Saeedeh Mouri, S. Mohammadi
Background: Despite the fast spread of COVID-19 around the world, no definitive treatment has been found for the disease yet. Various drugs have been tried to reduce the mortality rate of the disease. In this regard, convalescent plasma therapy is a beneficial method to control the illness. Objective: This study aims to determine the outcomes of patients receiving this therapy in Bu-Ali Hospital, Qazvin, Iran. Methods: The present study is a case series of 60 samples. The samples were selected by purposive sampling method. The study was conducted after ethical approval and patients’ consent in 2020. The inclusion criteria were having a lung scan confirming the disease by an internist or infectious disease specialist, a positive PCR test, and a history of receiving plasma during treatment. Results: Out of 60 patients with COVID-19 who received convalescent plasma, 33 (55%) survived. The findings indicate that patients who received plasma and died were not significantly different from surviving patients regarding age, sex, underlying disease, and length of hospital stay (P>0.05). However, there was a significant difference between the deceased and surviving patients regarding plasma receiving time (P=0.005). Conclusion: If the convalescent plasma therapy of patients starts closer to the time of admission, the effect of therapy on reducing patient mortality will be greater.
背景:尽管COVID-19在全球迅速传播,但尚未找到针对该疾病的明确治疗方法。已经尝试了各种药物来降低这种疾病的死亡率。在这方面,恢复期血浆治疗是控制病情的有益方法。目的:本研究旨在确定伊朗Qazvin Bu-Ali医院接受这种治疗的患者的预后。方法:本研究是一个60个样本的病例系列研究。采用目的抽样法选取样本。该研究是在2020年获得伦理批准和患者同意后进行的。纳入标准是由内科医生或传染病专家进行肺部扫描确认疾病,PCR检测阳性,以及治疗期间接受血浆治疗的历史。结果:60例接受恢复期血浆治疗的新冠肺炎患者中,33例(55%)存活。结果显示,接受血浆治疗后死亡的患者在年龄、性别、基础疾病、住院时间等方面与存活患者无显著差异(P>0.05)。然而,在接受血浆治疗的时间上,死亡患者与存活患者有显著差异(P=0.005)。结论:如果患者的恢复期血浆治疗在入院前开始,治疗对降低患者死亡率的效果将更大。
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Journal of inflammatory bowel diseases & disorders
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