{"title":"紫杉对uva照射下正常人表皮角质形成细胞的抗衰老作用","authors":"Joong Hyun Shim","doi":"10.22889/kjp.2023.54.3.96","DOIUrl":null,"url":null,"abstract":"This research was conducted to investigate the anti-aging and moisturizing effects Carpomitra costata extract on normal human epidermal keratinocytes (NHEKs). Moisturizing effects of C. costata extract on NHEKs were determined by quantitative real-time RT-PCR to identify cell viability assays, the mRNA levels associated with skin hydration, and hyaluronic acid (HA)-ELISA to detect HA production. C. costata extract increased mRNA levels of AQP3 and HAS2 genes and HA production in UVA-irradiated NHEKs. On the other hand, C. costata extract decreased the gene expressions of the FLG, KRT1 and KRT10 known as differentiated keratinocyte marker in NHEKs. This research showed the moisturizing effects of C. costata extract. The results indicate that C. costata extract can be a functional ingredient in skin moisturizing and anti-aging products. Further study is warranted regarding the use of C. costata extract to develop not only cosmeceutics but also food and medicine.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"11 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-aging Effect of Carpomitra costata in UVA-irradiated Normal Human Epidermal Keratinocytes\",\"authors\":\"Joong Hyun Shim\",\"doi\":\"10.22889/kjp.2023.54.3.96\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This research was conducted to investigate the anti-aging and moisturizing effects Carpomitra costata extract on normal human epidermal keratinocytes (NHEKs). Moisturizing effects of C. costata extract on NHEKs were determined by quantitative real-time RT-PCR to identify cell viability assays, the mRNA levels associated with skin hydration, and hyaluronic acid (HA)-ELISA to detect HA production. C. costata extract increased mRNA levels of AQP3 and HAS2 genes and HA production in UVA-irradiated NHEKs. On the other hand, C. costata extract decreased the gene expressions of the FLG, KRT1 and KRT10 known as differentiated keratinocyte marker in NHEKs. This research showed the moisturizing effects of C. costata extract. The results indicate that C. costata extract can be a functional ingredient in skin moisturizing and anti-aging products. Further study is warranted regarding the use of C. costata extract to develop not only cosmeceutics but also food and medicine.\",\"PeriodicalId\":17851,\"journal\":{\"name\":\"Korean Journal of Pharmacognosy\",\"volume\":\"11 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Korean Journal of Pharmacognosy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22889/kjp.2023.54.3.96\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Pharmacognosy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22889/kjp.2023.54.3.96","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Anti-aging Effect of Carpomitra costata in UVA-irradiated Normal Human Epidermal Keratinocytes
This research was conducted to investigate the anti-aging and moisturizing effects Carpomitra costata extract on normal human epidermal keratinocytes (NHEKs). Moisturizing effects of C. costata extract on NHEKs were determined by quantitative real-time RT-PCR to identify cell viability assays, the mRNA levels associated with skin hydration, and hyaluronic acid (HA)-ELISA to detect HA production. C. costata extract increased mRNA levels of AQP3 and HAS2 genes and HA production in UVA-irradiated NHEKs. On the other hand, C. costata extract decreased the gene expressions of the FLG, KRT1 and KRT10 known as differentiated keratinocyte marker in NHEKs. This research showed the moisturizing effects of C. costata extract. The results indicate that C. costata extract can be a functional ingredient in skin moisturizing and anti-aging products. Further study is warranted regarding the use of C. costata extract to develop not only cosmeceutics but also food and medicine.
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