用大鼠-小鼠脑嵌合体跨越再生神经科学中的物种界限

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2024-06-17 DOI:10.1038/s41684-024-01394-3

Stefano Pluchino, Ivan Lombardi

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引用次数: 0

摘要

了解器官生成的内在复杂性和解决器官捐献者持续短缺的问题仍然是科学界面临的重大挑战。嵌合囊胚技术的最新进展提供了前景广阔的解决方案。两项新的开创性研究成功生成了功能性大鼠-小鼠脑嵌合体，为大脑发育和潜在再生疗法提供了新的见解。然而，一些技术和伦理障碍依然存在。

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Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras

Understanding the inherent complexity of organogenesis and addressing the persistent shortage of organ donors remain paramount scientific challenges. Recent advances in chimeric blastocyst technology offer promising solutions. Two new pioneering studies have successfully generated functional rat–mouse brain chimeras, providing novel insights into brain development and potential regenerative therapies. However, several technical and ethical hurdles persist.

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.