利用同步辐射 X 射线散射研究的系统回顾和荟萃分析研究胶原基组织的变形

IF 7.9 2区 综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY Cell Reports Physical Science Pub Date : 2024-09-18 DOI:10.1016/j.xcrp.2024.102212
Lander Manrique, Mahmoud S. Moussa, Muhammad Talal Khan, Kawkab Tahboub, Robert O. Ritchie, Meisam Asgari, Elizabeth A. Zimmermann
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摘要

胶原纤维是从鱼鳞、肌腱到骨骼等多种组织的组成部分。同步加速器小角 X 射线散射(SAXS)和原位机械测试是研究胶原纤维变形的有力工具。有必要结合 SAXS 研究的数据来研究结构与功能的关系。文献检索使用了力学性能、胶原蛋白和 SAXS 等概念,共有 52 篇文章符合资格标准。在此,我们报告了矿化组织将更大比例的组织尺度变形转移到纤维上的情况:皮质骨为 67%,肌腱为 49%,韧带为 10%,皮肤为 3%。在非矿化组织中,复杂性较低、弹性蛋白含量较高的组织转移到纤维的变形较少。荟萃分析发现,与对照组相比,人体衰老和疾病中的纤维应变降低了20%-40%,从而导致骨折风险。这篇综述展示了组成和结构的变化如何调整基于胶原蛋白的组织的材料特性。
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Deformation of collagen-based tissues investigated using a systematic review and meta-analysis of synchrotron x-ray scattering studies

Collagen fibrils are the building blocks of many tissues from fish scales and tendons to bone. Synchrotron small-angle X-ray scattering (SAXS) with in situ mechanical testing is a powerful tool to investigate collagen fibril deformation. There is a need to combine data from SAXS studies to investigate structure-function relationships. A literature search used the concepts of mechanical properties, collagen, and SAXS, with 52 articles meeting the eligibility criteria. Here, we report that mineralized tissues transfer a greater proportion of tissue-scale deformation to the fibril: 67% for cortical bone, 49% for tendon, 10% for ligament, and 3% for skin. Across non-mineralized tissues, tissues with less complexity and greater elastin content transfer less deformation to the fibril. The meta-analysis finds 20%–40% lower fibril strain in human aging and disease compared to controls, which contributes toward fracture risk. This synthesis demonstrates how variations in composition and structure tune material properties in collagen-based tissues.

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来源期刊
Cell Reports Physical Science
Cell Reports Physical Science Energy-Energy (all)
CiteScore
11.40
自引率
2.20%
发文量
388
审稿时长
62 days
期刊介绍: Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.
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