血液过滤器关键参数的时间演变--同流下的体外研究

IF 3.3 4区 工程技术 Q2 CHEMISTRY, PHYSICAL Membranes Pub Date : 2024-09-21 DOI:10.3390/membranes14090200
Anastasios J Karabelas, Alexandra Moschona, Konstantinos Merenidis
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引用次数: 0

摘要

有效渗透率 KP、超滤系数 (KUF)、筛分系数 (SC) 和蛋白质(主要是白蛋白)的损失/渗透率是表征血液过滤器(HF)性能的关键参数/规格。然而,这些参数的确定还存在不确定性。这项工作的目的是:(a) 证明在相当均匀的局部跨膜压力 (TMP) 下,血液和透析液的同向流动可实现有益的单向过滤(从血液/血浆到透析液),这与目前采用的逆向流动不同;(b) 研究同向流动下关键的高频性能参数的时间演变,尤其是在重要的早期血液净化 (HC) 阶段。人血浆和 BSA 溶液在共流模式下的实验(为此开发了一个流体力学模型)表明,局部/轴向 TMP 相当均匀,这也改善了蛋白质膜污垢的局部/轴向均匀性,尤其是在(目前最受欢迎的)高对流通量操作下。由于初期的膜污垢,观察到有效 KP 有显著的时间变化/下降,进而观察到其他参数(即白蛋白和总蛋白的 Kuf、SC 和渗透/质量通量 Mm)也有显著的时间变化/下降。白蛋白/蛋白质质量通量 Mm 与渗透性 KP 的相关性令人满意,表明两者之间存在很强的相互依存关系。总之,同向流动可使局部 TMP 轴向均匀,从而获得有关高频参数演变的准确/代表性数据,便于解释和关联。新的结果为探索同向流的临床应用提供了基础。
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On the Temporal Evolution of Key Hemofilter Parameters-In Vitro Study under Co-Current Flow.

Effective permeability KP, the ultrafiltration coefficient (KUF), the sieving coefficient (SC), and the loss/permeation of proteins (primarily albumin) are key parameters/specifications characterizing hemofilter (HF) performance. However, there are uncertainties regarding their determination. This work aims (a) to demonstrate that the co-current flow (of blood and dialysate) can lead to beneficial unidirectional filtration (from blood/plasma to dialysate) under a fairly uniform local trans-membrane pressure (TMP), unlike the presently employed counter-current flow; (b) to study the temporal evolution of key HF performance parameters under co-current flow, particularly during the important early stage of hemocatharsis (HC). Experiments with human plasma and BSA solutions in co-current flow mode (for which a fluid mechanical model is developed) show a fairly uniform local/axial TMP, which also improves the local/axial uniformity of protein membrane fouling, particularly under (currently favored) high convective flux operation. Due to incipient membrane fouling, a significant temporal variability/decline in the effective KP is observed, and, in turn, of other parameters (i.e., the Kuf, SC, and permeation/mass flux Mm for albumin and total proteins). A satisfactory correlation of the albumin/protein mass flux Mm with permeability KP is obtained, indicating strong inter-dependence. In conclusion, co-current flow, allowing for a fair local TMP axial uniformity, enables the acquisition of accurate/representative data on the evolution of HF parameters, facilitating their interpretation and correlation. The new results provide a basis for exploring the clinical application of the co-current flow.

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来源期刊
Membranes
Membranes Chemical Engineering-Filtration and Separation
CiteScore
6.10
自引率
16.70%
发文量
1071
审稿时长
11 weeks
期刊介绍: Membranes (ISSN 2077-0375) is an international, peer-reviewed open access journal of separation science and technology. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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