{"title":"不同狭窄程度对冠状动脉左前降支血小板沉积的影响。","authors":"Yiming Zhao , Haoyao Cao , Yongtao Wei , Tinghui Zheng","doi":"10.1016/j.cmpb.2024.108445","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>This study aimed to investigate the impact of different stenotic degrees on platelet deposition in the left anterior descending branch of the coronary artery.</div></div><div><h3>Methods</h3><div>The idealized model of coronary artery stenosis of 30 %, 40 %, 50 %, 60 %, 70 % and four patient-specific models of 22.17 %, 34.88 %, 51.23 % and 62.96 % were established. A discrete phase model was used to calculate the deposition of platelet particles in blood.</div></div><div><h3>Results</h3><div>(1) As the stenotic degree increased from 30 % to 70 %, the maximum deposition rates were 4.23e<sup>-</sup><sup>2</sup> kg/(m<sup>2</sup> ·s), 3.47e<sup>-</sup><sup>2</sup> kg/(m<sup>2</sup> ·s), 0.14 kg/(m<sup>2</sup> ·s), 0.15 kg/(m<sup>2</sup> ·s), and 0.38 kg/(m<sup>2</sup> ·s), respectively. (2) The greater the stenotic degree, the more points of platelet deposition. (3) Platelets were mainly deposited at the proximal segment of mild stenosis. When the stenotic degree exceeded 50 %, the deposition position moved to the distal segment of the stenosis. (4) The results in the real coronary artery models were similar to those in the idealized model.</div></div><div><h3>Conclusion</h3><div>The study suggests that the location and number of platelet deposition are related to the degree of stenosis. Moderate to severe stenosis is more likely to spread downstream.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":"257 ","pages":"Article 108445"},"PeriodicalIF":4.9000,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The impact of different degrees of stenosis on platelet deposition in the left anterior descending branch of the coronary artery\",\"authors\":\"Yiming Zhao , Haoyao Cao , Yongtao Wei , Tinghui Zheng\",\"doi\":\"10.1016/j.cmpb.2024.108445\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objective</h3><div>This study aimed to investigate the impact of different stenotic degrees on platelet deposition in the left anterior descending branch of the coronary artery.</div></div><div><h3>Methods</h3><div>The idealized model of coronary artery stenosis of 30 %, 40 %, 50 %, 60 %, 70 % and four patient-specific models of 22.17 %, 34.88 %, 51.23 % and 62.96 % were established. A discrete phase model was used to calculate the deposition of platelet particles in blood.</div></div><div><h3>Results</h3><div>(1) As the stenotic degree increased from 30 % to 70 %, the maximum deposition rates were 4.23e<sup>-</sup><sup>2</sup> kg/(m<sup>2</sup> ·s), 3.47e<sup>-</sup><sup>2</sup> kg/(m<sup>2</sup> ·s), 0.14 kg/(m<sup>2</sup> ·s), 0.15 kg/(m<sup>2</sup> ·s), and 0.38 kg/(m<sup>2</sup> ·s), respectively. (2) The greater the stenotic degree, the more points of platelet deposition. (3) Platelets were mainly deposited at the proximal segment of mild stenosis. When the stenotic degree exceeded 50 %, the deposition position moved to the distal segment of the stenosis. (4) The results in the real coronary artery models were similar to those in the idealized model.</div></div><div><h3>Conclusion</h3><div>The study suggests that the location and number of platelet deposition are related to the degree of stenosis. Moderate to severe stenosis is more likely to spread downstream.</div></div>\",\"PeriodicalId\":10624,\"journal\":{\"name\":\"Computer methods and programs in biomedicine\",\"volume\":\"257 \",\"pages\":\"Article 108445\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer methods and programs in biomedicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169260724004383\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260724004383","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
The impact of different degrees of stenosis on platelet deposition in the left anterior descending branch of the coronary artery
Background and objective
This study aimed to investigate the impact of different stenotic degrees on platelet deposition in the left anterior descending branch of the coronary artery.
Methods
The idealized model of coronary artery stenosis of 30 %, 40 %, 50 %, 60 %, 70 % and four patient-specific models of 22.17 %, 34.88 %, 51.23 % and 62.96 % were established. A discrete phase model was used to calculate the deposition of platelet particles in blood.
Results
(1) As the stenotic degree increased from 30 % to 70 %, the maximum deposition rates were 4.23e-2 kg/(m2 ·s), 3.47e-2 kg/(m2 ·s), 0.14 kg/(m2 ·s), 0.15 kg/(m2 ·s), and 0.38 kg/(m2 ·s), respectively. (2) The greater the stenotic degree, the more points of platelet deposition. (3) Platelets were mainly deposited at the proximal segment of mild stenosis. When the stenotic degree exceeded 50 %, the deposition position moved to the distal segment of the stenosis. (4) The results in the real coronary artery models were similar to those in the idealized model.
Conclusion
The study suggests that the location and number of platelet deposition are related to the degree of stenosis. Moderate to severe stenosis is more likely to spread downstream.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.