Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo
{"title":"新的无棕榈结构脂能减轻瑞士小鼠高脂餐诱导的餐后高脂血症和炎症吗？","authors":"Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo","doi":"10.1080/27697061.2024.2449524","DOIUrl":null,"url":null,"abstract":"<p><p>A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.</p><p><p><b>Objective:</b> We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.</p><p><p><b>Methods:</b> SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.</p><p><p><b>Results:</b> SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.</p><p><p><b>Conclusions:</b> Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-9"},"PeriodicalIF":6.8000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?\",\"authors\":\"Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo\",\"doi\":\"10.1080/27697061.2024.2449524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.</p><p><p><b>Objective:</b> We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.</p><p><p><b>Methods:</b> SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.</p><p><p><b>Results:</b> SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.</p><p><p><b>Conclusions:</b> Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption.</p>\",\"PeriodicalId\":29768,\"journal\":{\"name\":\"Journal of the American Nutrition Association\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2025-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the American Nutrition Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/27697061.2024.2449524\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Nutrition Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/27697061.2024.2449524","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?
A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.
Objective: We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.
Methods: SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.
Results: SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.
Conclusions: Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption.
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