自发性但可预测的室性心律失常的发生模型。

European journal of cardiology Pub Date : 1981-01-01
S C Dennis, D J Hearse, D J Coltart
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引用次数: 0

摘要

一种实验制剂的发展,有助于研究影响自发性和可预测的室性心律失常发生率的致心律失常和抗心律失常因素。利用离体灌注豚鼠心脏和基于心跳间隔计算机辅助统计分析的心律失常定量系统,研究了影响心律失常发生率的若干因素。对灌注液成分的操作显示,在“中度”缺血后,在去甲肾上腺素和非葡萄糖燃料的存在下,再灌注心律失常增加。游离脂肪酸,除非存在儿茶酚胺,不是特别心律失常。相反,糖酵解的最终产物抑制剂丙酮酸或乳酸的存在显著增加了回流节律紊乱的发生率。丙酮酸的剂量依赖性致心律失常作用和葡萄糖的抗致心律失常作用支持了糖酵解通量不足可能是心律失常发生的重要因素这一论点。
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A model for the generation of spontaneous yet predictable ventricular arrhythmias.

Development of an experimental preparation aided to investigate arrhythmogenic and antiarrhythmogenic factors influencing incidence of spontaneous and yet predictable ventricular arrhythmias is described. Using the isolated perfused guinea-pig heart and a system for quantitating rhythm disturbances based on computer-aided statistical analysis of beat-to-beat intervals, a number of factors influencing the incidence of rhythm disturbances were investigated. Manipulation of perfusate composition revealed that, after 'moderate' ischaemia, reperfusion arrhythmias were increased in the presence of noradrenaline and non-glucose fuels. Free fatty acids, unless in the presence of catecholamines, were not particularly arrhythmogenic. In contrast, the presence of pyruvate or lactate, endproduct inhibitors of glycolysis, significantly increased incidence of reflow rhythm disturbances. The dose-dependent arrhythmogenic effects of pyruvate and anti-arrhythmogenic effects of glucose support the thesis that inadequate glycolytic flux could be important in the development of arrhythmias.

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