美西汀的电生理特性与血浆浓度的关系。

European journal of cardiology Pub Date : 1980-02-01
S P Joseph, D W Holt
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引用次数: 0

摘要

对14例预兴奋综合征患者静脉注射美西汀前后进行电生理测量。单次输注3mg /kg体重的美西汀后,血浆浓度迅速下降,15分钟后电生理测量无明显变化。当第二次静脉输注时,血浆美西汀浓度升高,产生药理学效应。结果表明,美西汀的最低有效血药浓度约为0.5 mg/l。副作用很小,其产生在很大程度上取决于药物输注的速度。在以前的研究中,电生理测量可能是在血浆美西汀浓度低于有效水平时进行的,这可以解释他们发现的差异。
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Electrophysiological properties of mexiletine assessed with respect to plasma concentrations.

Electrophysiological measurements were made before and after the intravenous administration of mexiletine in 14 patients with preexcitation syndromes. Following a single infusion of 3 mg/kg body weight plasma concentrations of mexiletine fell rapidly and after 15 min, significant changes in electrophysiological measurements were not found. Higher plasma mexiletine concentrations, bringing about a pharmacological effect, were attained when a second intravenous infusion was also given. The results suggest a minimum effective plasma concentration for mexiletine of about 0.5 mg/l. Side-effects were minimal and their production was largely dependent on the rate of drug infusion. Electrophysiological measurements in previous studies may have been made at a time when plasma mexiletine concentrations were below an effective level and this could explain a disparity in their findings.

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