R S Meltzer, J N Woythaler, A J Buda, J C Griffin, R Kernoff, D C Harrison, R L Popp, R P Martin
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引用次数: 0
摘要
为了研究二维超声心动图检测到的壁运动异常是否可以量化并与梗死面积相关,我们将实验性犬梗死的二维超声心动图观察到的壁运动异常与死后梗死面积进行了比较。19只杂种狗接受左冠状动脉前降支陷阱闭塞。6小时后处死。用99-m焦磷酸亚锡锝显像对切除的左心室切片进行梗死面积测定。14只犬同时出现二维回声壁运动异常和梗死。4只狗没有发生梗死,没有或只有轻微的壁运动异常。二维超声心动图测量结果的观察者间差异很小。在14只狗梗死亚组(r = 0.75, P < 0.003)和所有18只狗完成方案(r = 0.87, P < 0.001)中,壁运动异常与梗死大小相关。因此,通过二维超声心动图可以大致量化实验性犬心肌梗死的壁运动异常,并与死后超声心动图测量的梗死面积相关。
Non-invasive quantification of experimental canine myocardial infarct size using two-dimensional echocardiography.
In order to study whether wall motion abnormalities detected by two-dimensional (2D) echocardiography can be quantified and correlated with infarct size, we compared wall motion abnormalities viewed by 2D echocardiography in experimental canine infarction with post-mortem infarct size. Nineteen mongrel dogs underwent left anterior descending coronary artery snare occlusion. They were sacrificed 6 h later. Infarct sizing was done by technetium 99-m stannous pyrophosphate scintigraphy of the excised, sliced left ventricles. Fourteen dogs had both 2D echo wall motion abnormalities and infarctions. Four dogs failed to develop infarction and had no or minimal wall motion abnormalities. Inter-observer variation in 2D echocardiographic measurements was small. Wall motion abnormalities correlated with infarct size both in the 14-dog subgroup with infarction (r = 0.75, P less than 0.003) and all the 18 dogs that completed the protocol (r = 0.87, P less than 0.001). Thus, wall motion abnormalities in experimental canine myocardial infraction can be roughly quantified by 2D echocardiography and correlated with post-mortem infarct size measured by scintigraphy.