不同感染部位分离的金黄色葡萄球菌毒力基因和耐甲氧西林基因检测及耐药谱

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Egyptian Pharmaceutical Journal Pub Date : 2023-04-01 DOI:10.4103/epj.epj_187_22
Rafal Ismael, A. Alhameedawi, Rajaa Abbas, Sarah Alsallameh, Halah Amer, Müge Firat, M. Karkhane
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引用次数: 0

摘要

背景金黄色葡萄球菌是最重要的致病菌之一,成人和儿童都容易从鼻子前部感染这种细菌。在美国,疾病控制和预防中心估计,2011年发生了80461例侵袭性耐甲氧西林金黄色葡萄球菌感染和11285例相关死亡。2021年,英国约有190人死于耐甲氧西林金黄色葡萄球菌。澳大利亚、香港、新加坡、日本和希腊以及全世界也有MRSA感染。1974年,耐甲氧西林金黄色葡萄球菌在美国引起的细菌性疾病不到2%,而在2004年,仅用了10年,这一比例就跃升至64%,使感染率增加了300%。目的本研究旨在检测药物敏感性模式、葡萄球菌肠毒素A至C、中毒性休克综合征毒素1和耐甲氧西林基因。材料与方法从萨拉赫丁教学医院不同感染点分离到98株金黄色葡萄球菌。对伊拉克萨拉赫丁市金黄色葡萄球菌的流行病学和毒力基因的研究很少。结果与结论金黄色葡萄球菌对常用抗生素的耐药率极高。在这项研究中,与之前的研究不同,没有检测到金黄色葡萄球菌菌株中毒性休克综合征毒素、sec B和sec C基因的表达。虽然所有菌株都是secA基因阳性,但在细菌细胞中发现的另一种使其对甲氧西林和其他万古霉素等抗生素具有耐药性的基因是mecA。
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Staphylococcus aureus virulence genes and methicillin-resistant gene detection and antimicrobial resistance profiles isolated from different infection sites
Background One of the most significant pathogenic bacteria is Staphylococcus aureus, and both adults and children are susceptible to this bacterium from the front of the nose. In the United States, the Centers for Disease Control and Prevention estimate that 80,461 invasive methicillin-resistant S. aureus (MRSA) infections and 11 285 related deaths occurred in 2011. In the UK, around 190 people passed away from MRSA disease in 2021. Australia, Hong Kong, Singapore, Japan, and Greece also have MRSA infections, along with the whole world. MRSA caused less than 2% of bacterial diseases in the United States in 1974, while the percentage rate jumped to 64% in 2004 only 10 years to increase the infection rate by 300%. Objective This study aimed to detect medication susceptibility patterns, staphylococcal enterotoxins A to C, toxic shock syndrome toxin-1, and methicillin-resistant genes. Materials and methods Ninety-eight S. aureus strains were isolated from different infection sites from Salah Al-Din Teaching Hospital. There have only been a few studies conducted on the epidemiology and virulence genes of S. aureus in Salah Al-Din city, Iraq. Results and conclusion The rates of drug resistance among S. aureus strains to routinely used antibiotics were found to be extremely high. In this study, the expression of toxic shock syndrome toxin, sec B, and sec C genes in S. aureus strains was not detected, unlike in previous studies. While all the strains were sec A gene positive, another gene found in bacterial cells that enables them to be resistant to antibiotics like methicillin and other vancomycin drugs is mecA.
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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