急性新冠肺炎患者的血氧饱和度降低和体温升高在很大程度上预测了长期COVID引起的慢性疲劳综合征和情感症状:一种精确的无意识方法

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2022-04-12 DOI:10.1101/2022.04.10.22273660
Dhurgham Shihab Al-Hadrawi, Haneen Tahseen Al-Rubaye, A. Almulla, H. Al-Hakeim, Michael Maes
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引用次数: 14

摘要

背景:2019年长期冠状病毒病(LC)是急性新冠肺炎的慢性后遗症。被标记为LC生理-情感现象的情感性、慢性疲劳和生理-躯体症状的确切病理生理学仍然难以捉摸。目的:本研究旨在探讨急性期血氧饱和度(SpO2)和体温对LC生理情感现象的影响。方法:我们招募了120名LC患者和36名对照者。对于所有参与者,我们评估了急性新冠肺炎期间的最低SpO2和最高体温,以及3-4个月后的汉密尔顿抑郁和焦虑评定量表(HAMD/HAMA)和纤维疲劳(FF)量表。结果:急性期SpO2降低和体温升高以及女性预测了LC生理-情感现象60.7%的方差。使用无监督学习技术,我们能够描绘出一个新的内表型类别,该类别约占LC患者的26.7%,其特征是SpO2非常低和体温非常高,以及抑郁、焦虑、,慢性疲劳以及自主神经和胃肠道症状评分。单个潜在载体可以从抑郁、焦虑和FF症状这两种生物标志物中提取,也可以从失眠、慢性疲劳、胃肠道和自主神经症状这两个生物标志物提取。结论:新构建的内表型类别和途径表型表明,LC的生理有效现象至少部分是急性新冠肺炎病理生理学的结果,即SpO2降低、体温升高以及相关免疫炎症过程和肺部病变的联合作用。
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Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to LONG COVID: a precision nomothetic approach
Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms labeled as physio-affective phenome of LC has remained elusive. Objective: The current study aims to delineate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on the physio-affective phenome of LC. Method: We recruited 120 LC patients and 36 controls. For all participants, we assessed the lowest SpO2 and peak body temperature during acute COVID-19, and the Hamilton Depression and Anxiety Rating Scale (HAMD/HAMA) and Fibro Fatigue (FF) scales 3 to 4 months later. Results: Lowered SpO2 and increased body temperature during the acute phase and female sex predict 60.7% of the variance in the physio-affective phenome of LC. Using unsupervised learning techniques we were able to delineate a new endophenotype class, which comprises around 26.7% of the LC patients and is characterized by very low SpO2 and very high body temperature, and depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms scores. Single latent vectors could be extracted from both biomarkers, depression, anxiety and FF symptoms or from both biomarkers, insomnia, chronic fatigue, gastro-intestinal and autonomic symptoms. Conclusion: The newly constructed endophenotype class and pathway phenotypes indicate that the physio-affective phenome of LC is at least in part the consequence of the pathophysiology of acute COVID-19, namely the combined effects of lowered SpO2, increased body temperature and the associated immune-inflammatory processes and lung lesions.
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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