Chenyang Ren , Ping Hou , Jian Li , Yan Huang , Liwei Pan , Liuting Peng , Chunqiu Gan , Xinlan Guan , Jun Li
{"title":"半枝莲树皮中的大斯的烷苷和酚苷。","authors":"Chenyang Ren , Ping Hou , Jian Li , Yan Huang , Liwei Pan , Liuting Peng , Chunqiu Gan , Xinlan Guan , Jun Li","doi":"10.1080/14786419.2023.2272284","DOIUrl":null,"url":null,"abstract":"<div><div>A new megastigmane glycoside, barbatcoside A (<strong>1</strong>), and two new phenol glycosides, barbatcosides B (<strong>2</strong>) and C (<strong>3</strong>), together with eight known compounds (<strong>4</strong>-<strong>11</strong>) were isolated from the bark of <em>Mallotus barbatus</em> Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds <strong>1</strong> and <strong>2</strong> were established based on the experimental CD curves. The anti-inflammatory activities of compounds <strong>1</strong>-<strong>11</strong> from <em>M. barbatus</em> were evaluated using LPS-stimulated RAW 264.7 cell models. Compounds <strong>2</strong> and <strong>3</strong> substantially inhibited the release of NO with IC<sub>50</sub> values of 34.78 <em>μ</em>M and 20.73 <em>μ</em>M, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 475-482"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Megastigmane glycoside and phenol glycosides from the bark of Mallotus barbatus\",\"authors\":\"Chenyang Ren , Ping Hou , Jian Li , Yan Huang , Liwei Pan , Liuting Peng , Chunqiu Gan , Xinlan Guan , Jun Li\",\"doi\":\"10.1080/14786419.2023.2272284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A new megastigmane glycoside, barbatcoside A (<strong>1</strong>), and two new phenol glycosides, barbatcosides B (<strong>2</strong>) and C (<strong>3</strong>), together with eight known compounds (<strong>4</strong>-<strong>11</strong>) were isolated from the bark of <em>Mallotus barbatus</em> Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds <strong>1</strong> and <strong>2</strong> were established based on the experimental CD curves. The anti-inflammatory activities of compounds <strong>1</strong>-<strong>11</strong> from <em>M. barbatus</em> were evaluated using LPS-stimulated RAW 264.7 cell models. Compounds <strong>2</strong> and <strong>3</strong> substantially inhibited the release of NO with IC<sub>50</sub> values of 34.78 <em>μ</em>M and 20.73 <em>μ</em>M, respectively.</div></div>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\"39 3\",\"pages\":\"Pages 475-482\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1478641923022210\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923022210","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Megastigmane glycoside and phenol glycosides from the bark of Mallotus barbatus
A new megastigmane glycoside, barbatcoside A (1), and two new phenol glycosides, barbatcosides B (2) and C (3), together with eight known compounds (4-11) were isolated from the bark of Mallotus barbatus Müll. Arg. Their structures were elucidated using extensive 1D and 2D NMR as well as HRESIMS spectroscopic data. The stereochemistry of compounds 1 and 2 were established based on the experimental CD curves. The anti-inflammatory activities of compounds 1-11 from M. barbatus were evaluated using LPS-stimulated RAW 264.7 cell models. Compounds 2 and 3 substantially inhibited the release of NO with IC50 values of 34.78 μM and 20.73 μM, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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