Mangaladoss Fredimoses , Wen Ai , Xiuping Lin , Xuefeng Zhou , Shengrong Liao , Li Pan , Yonghong Liu
{"title":"从海洋海绵相关真菌变色曲霉SCSIO XWS04 F52中分离出两种新的毛曲霉蛋白酶A和B，以及一种新的土霉素衍生物。","authors":"Mangaladoss Fredimoses , Wen Ai , Xiuping Lin , Xuefeng Zhou , Shengrong Liao , Li Pan , Yonghong Liu","doi":"10.1080/14786419.2023.2275744","DOIUrl":null,"url":null,"abstract":"<div><div>Two new alkaloids, Aspera chaetominines A (<strong>1</strong>) and B (<strong>2</strong>), a new derivative (<strong>3</strong>) of terrein, and together with <strong>11</strong> known compounds (<strong>4–14</strong>) were isolated from marine sponge <em>Callyspongia</em> sp. -derived fungus <em>Aspergillus versicolour</em> SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of <strong>1–3</strong> were determined by spectroscopic (<sup>1</sup>H, <sup>13</sup>C NMR, HSQC, HMBC, and <sup>1</sup>H-<sup>1</sup>H COSY), and MS analysis. Compounds <strong>1</strong> and <strong>2</strong> showed cytotoxic activity against leukaemia K562 and colon cancer cells SW1116 with IC<sub>50</sub> 7.5 to 12.5 <em>μ</em>M, and also compounds <strong>1</strong> and <strong>2</strong> exhibited significant protection against H1N1 virus-induced cytopathogenicity in MDCK cells with IC<sub>50</sub> values of 15.5 and 24.5 <em>μ</em>M, respectively.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"39 3","pages":"Pages 566-578"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two new Aspera chaetominines A and B, and a new derivative of terrein, isolated from marine sponge associated fungus Aspergillus versicolour SCSIO XWS04 F52\",\"authors\":\"Mangaladoss Fredimoses , Wen Ai , Xiuping Lin , Xuefeng Zhou , Shengrong Liao , Li Pan , Yonghong Liu\",\"doi\":\"10.1080/14786419.2023.2275744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new alkaloids, Aspera chaetominines A (<strong>1</strong>) and B (<strong>2</strong>), a new derivative (<strong>3</strong>) of terrein, and together with <strong>11</strong> known compounds (<strong>4–14</strong>) were isolated from marine sponge <em>Callyspongia</em> sp. -derived fungus <em>Aspergillus versicolour</em> SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of <strong>1–3</strong> were determined by spectroscopic (<sup>1</sup>H, <sup>13</sup>C NMR, HSQC, HMBC, and <sup>1</sup>H-<sup>1</sup>H COSY), and MS analysis. Compounds <strong>1</strong> and <strong>2</strong> showed cytotoxic activity against leukaemia K562 and colon cancer cells SW1116 with IC<sub>50</sub> 7.5 to 12.5 <em>μ</em>M, and also compounds <strong>1</strong> and <strong>2</strong> exhibited significant protection against H1N1 virus-induced cytopathogenicity in MDCK cells with IC<sub>50</sub> values of 15.5 and 24.5 <em>μ</em>M, respectively.</div></div>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\"39 3\",\"pages\":\"Pages 566-578\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1478641923022568\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923022568","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Two new Aspera chaetominines A and B, and a new derivative of terrein, isolated from marine sponge associated fungus Aspergillus versicolour SCSIO XWS04 F52
Two new alkaloids, Aspera chaetominines A (1) and B (2), a new derivative (3) of terrein, and together with 11 known compounds (4–14) were isolated from marine sponge Callyspongia sp. -derived fungus Aspergillus versicolour SCSIO XWS04 F52, which was identified on the basis of morphology and ITS sequence analysis. The planar structures of 1–3 were determined by spectroscopic (1H, 13C NMR, HSQC, HMBC, and 1H-1H COSY), and MS analysis. Compounds 1 and 2 showed cytotoxic activity against leukaemia K562 and colon cancer cells SW1116 with IC50 7.5 to 12.5 μM, and also compounds 1 and 2 exhibited significant protection against H1N1 virus-induced cytopathogenicity in MDCK cells with IC50 values of 15.5 and 24.5 μM, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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