Microfabrication technology for polycaprolactone, a biodegradable polymer

D. Armani, Chang Liu
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引用次数: 128

Abstract

In this paper, we report the development of micromachining techniques for a biodegradable polymer for the first time. By virtue of their ability to naturally degrade in tissues, biodegradable polymers hold immense promise as new materials for implantable biomedical microdevices. This work focuses on establishment of microfabrication processes for biodegradable microstructures and microdevices. Three unique fabrication processes have been established: (1) micro-molding process to form 3D microstructures in polycaprolactone (PCL) via a silicon micromachined mold; (2) a method of transferring metal patterns to surfaces of PCL substrates; (3) techniques for sealing both dry and liquid-filled PCL micro-cavities with a metal thin film (e.g. gold). Chemical compatibility of PCL with common micromachining chemicals have been investigated.
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生物可降解聚合物聚己内酯的微加工技术
本文首次报道了生物可降解聚合物微加工技术的发展。由于其在组织中自然降解的能力,可生物降解聚合物作为植入式生物医学微设备的新材料具有巨大的前景。这项工作的重点是建立可生物降解的微结构和微器件的微加工工艺。建立了三种独特的制造工艺:(1)通过硅微机械模具形成聚己内酯(PCL)的三维微结构的微成型工艺;(2)一种将金属图案转移到PCL基板表面的方法;(3)用金属薄膜(如金)密封干燥和充满液体的PCL微腔的技术。研究了PCL与常用微加工化学品的化学相容性。
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