Improved micro-flow regulator for drug delivery systems

Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090) Pub Date : 2001-01-21 DOI:10.1109/MEMSYS.2001.906595

P. Cousseau, R. Hirschi, B. Frehner, S. Gamper, D. Maillefer

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引用次数: 29

Abstract

The paper reports on the design, manufacturing, and experimental testing of a micromachined pressure compensating flow regulator. This device was designed to provide a constant liquid flow rate of 1 ml/hr within a pressure difference of 100 to 600 mbar. At pressures higher than 600 mbar the device is designed to block the flow, preventing an over-delivery of medicine. Structural and fluidic simulations were used to design the geometry of the device before manufacturing. After devices have been characterized experimental results demonstrate the credibility of the design, the accuracy of the flow rate and the long-term stability of the device. One application of this device is the replacement of the flow restrictor in an elastomeric infusion system, which will increase the accuracy and safety of the drug delivery system. This pressure compensating flow regulator is passive, hence it needs no external energy source. The device is relatively inexpensive to manufacture and is therefore, potentially a disposable unit in a microfluidic system. Finally, it is small and lightweight, ideal for portable applications.

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改进的药物输送系统微流量调节器

本文介绍了一种微型机械压力补偿式流量调节器的设计、制造和实验测试。该装置设计用于在100至600毫巴的压力差范围内提供1毫升/小时的恒定液体流速。当压力高于600毫巴时，该装置被设计成阻塞流动，防止药物过量输送。在制造之前，使用结构和流体模拟来设计装置的几何形状。在对装置进行了表征后，实验结果证明了设计的可信性、流量的准确性和装置的长期稳定性。该装置的一个应用是替代弹性输液系统中的流量限制器，这将提高药物输送系统的准确性和安全性。这种压力补偿式流量调节器是被动的，因此不需要外部能源。该装置制造成本相对较低，因此有可能成为微流体系统中的一次性装置。最后，它体积小、重量轻，是便携式应用的理想选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090)

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