Cumulative stressor exposure and cognitive functioning in late childhood: The role of inflammation

Abstract

This study examined whether the experience of stressors since infancy is related to executive function and social communication in late childhood via inflammation, using data from 4457 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC). It explored whether the effect of stressful life events (from 6 months to 8.5 years) on working memory, response inhibition, selective attention, attentional control, communication problems and social cognition (at ages 10–11 years) was mediated by inflammation (interleukin 6 and C-reactive protein) at age 9 years. While the study did not find evidence for mediation, it showed that, in the general child population, inflammation was related to executive function impairments, and stressful life events were related to social communication difficulties. These associations were small but robust to confounder adjustment. If causal, they suggest that reducing inflammation could improve executive functioning, the prerequisite to any purposeful and goal-directed action.