Sonia A Clark, Remi Philips, Christine E Kistler, Adam O Goldstein, Chineme Enyioha
Background: Mobile health (mHealth) interventions show promise in supporting tobacco cessation. However, Black adults who use tobacco products are not well represented in mHealth studies for tobacco cessation, and their preferred features of mHealth apps are not well known. Identifying types of mHealth app features for tobacco cessation preferred by Black adults is critical to developing a culturally adapted app, with increased uptake by the target population.
Objective: The goal of this study was to explore culturally relevant preferences for features of smoking cessation mHealth apps among Black adults who use tobacco products.
Methods: A comprehensive list of features of mHealth apps for tobacco cessation was developed based on previous research and a review of existing mHealth literature. Through a content analysis, this list was divided into subgroups and used to develop a focus group guide. We recruited participants from Instagram, a social media platform. Eligible focus group participants included people who reported current use of a tobacco product, identified as being African American or Black, were 21 years old or older, and had access to Wi-Fi or the internet. Participants had to indicate interest in the use of an mHealth app for tobacco cessation. Participants discussed their opinions about different app features, including what features they felt would increase the use of an app by Black adults. Recordings from the focus groups were transcribed and coded deductively and inductively. We conducted a thematic content analysis of the resulting transcripts.
Results: Forty adults aged 21-69 (mean 43, SD 13.6) years participated in 8 focus groups. Fifty-seven percent were female, and 88% endorsed current cigarette use. Four central themes that represented app features emerged. (1) Participants wanted representation and inclusivity through personalization and featuring people with similar lived experiences, including representative images and relevant health information. (2) Participants desired the app to feature a diversity of experiences such as testimonials from individuals from different backgrounds rather than solely focusing on racial identity or excessive targeting of the Black community. (3) Participants desired accountability through trusted connections with health care professionals and other support groups within the app, as well as app tracking capability. (4) Encouragement and motivation were more salient incentives than monetary rewards.
Conclusions: Black adults who use tobacco products prefer a tobacco cessation app with features that are inclusive, relatable, supportive, and motivating. These findings can serve as the groundwork for the development of an mHealth app that will appeal to Black adults, potentially leading to increased app use, successful cessation, and health equity.
{"title":"Features of Mobile Health Apps for Tobacco Cessation That Appeal to Black Adults Who Use Tobacco Products: Focus Group Study.","authors":"Sonia A Clark, Remi Philips, Christine E Kistler, Adam O Goldstein, Chineme Enyioha","doi":"10.2196/63340","DOIUrl":"10.2196/63340","url":null,"abstract":"<p><strong>Background: </strong>Mobile health (mHealth) interventions show promise in supporting tobacco cessation. However, Black adults who use tobacco products are not well represented in mHealth studies for tobacco cessation, and their preferred features of mHealth apps are not well known. Identifying types of mHealth app features for tobacco cessation preferred by Black adults is critical to developing a culturally adapted app, with increased uptake by the target population.</p><p><strong>Objective: </strong>The goal of this study was to explore culturally relevant preferences for features of smoking cessation mHealth apps among Black adults who use tobacco products.</p><p><strong>Methods: </strong>A comprehensive list of features of mHealth apps for tobacco cessation was developed based on previous research and a review of existing mHealth literature. Through a content analysis, this list was divided into subgroups and used to develop a focus group guide. We recruited participants from Instagram, a social media platform. Eligible focus group participants included people who reported current use of a tobacco product, identified as being African American or Black, were 21 years old or older, and had access to Wi-Fi or the internet. Participants had to indicate interest in the use of an mHealth app for tobacco cessation. Participants discussed their opinions about different app features, including what features they felt would increase the use of an app by Black adults. Recordings from the focus groups were transcribed and coded deductively and inductively. We conducted a thematic content analysis of the resulting transcripts.</p><p><strong>Results: </strong>Forty adults aged 21-69 (mean 43, SD 13.6) years participated in 8 focus groups. Fifty-seven percent were female, and 88% endorsed current cigarette use. Four central themes that represented app features emerged. (1) Participants wanted representation and inclusivity through personalization and featuring people with similar lived experiences, including representative images and relevant health information. (2) Participants desired the app to feature a diversity of experiences such as testimonials from individuals from different backgrounds rather than solely focusing on racial identity or excessive targeting of the Black community. (3) Participants desired accountability through trusted connections with health care professionals and other support groups within the app, as well as app tracking capability. (4) Encouragement and motivation were more salient incentives than monetary rewards.</p><p><strong>Conclusions: </strong>Black adults who use tobacco products prefer a tobacco cessation app with features that are inclusive, relatable, supportive, and motivating. These findings can serve as the groundwork for the development of an mHealth app that will appeal to Black adults, potentially leading to increased app use, successful cessation, and health equity.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e63340"},"PeriodicalIF":6.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qimeng Zhao, Alison Cooke, Lishan Huang, Yimin Tang, Dawn Dowding
Background: The use of mobile health (mHealth) apps can assist with the management of gestational diabetes (GDM). Although a number of studies have demonstrated their efficacy in improving maternal-fetal outcomes, opinions differ regarding their usability and overall quality. Poorly designed apps, with ill-conceived features or inappropriate content, may pose a threat to patient safety. Nevertheless, very few studies provide in-depth evaluations of app design quality, and the diversity of features and techniques used remains insufficiently explored.
Objective: We aimed to evaluate the quality and multifunctionality of commercially available mHealth apps for GDM.
Methods: This is a systematic app review guided by the TECH (target user, evaluation focus, connectedness, and health domain) framework and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist. Searches were conducted on the Apple App Store and Google Play. Apps were screened by name, description, and full navigation to identify inclusions. The quality of the apps was evaluated using the Mobile App Rating Scale and IMS Institute for Healthcare Informatics Functionality Score. Multifunctionality of the apps was evaluated using the GDM-adapted features and techniques list developed from the App Behavior Change Scale, NICE (National Institute for Health and Care Excellence) 2015 guidelines, and previous studies. The general features list, which contains instruction, data security, customization, and technical issues, was derived from previous studies.
Results: The search (June 2024) identified 23 commercially available apps from UK app stores. The overall app quality was evaluated to be satisfactory (Mobile App Rating Scale: mean 4.0, SD 0.36; IMS Institute for Healthcare Informatics Functionality Score: mean 5.83, SD 3.03). The multifunctionality evaluation found that the apps had a mean of 17.95 and SD of 7.31 across all 45 items. Overall, our findings suggested that mHealth apps for GDM achieved a certain level of multifunctionality. However, their feature types and supporting digital techniques are relatively basic. The apps focused on education and managing blood glucose control rather than integrating other self-monitoring data and pregnancy-relevant management into their design. The digital techniques used to achieve these features included text and manual operation, rather than other automated features.
Conclusions: This is the first app review to consider the relationship between app features and usability for women with GDM. Future app development should integrate a wide range of pregnancy-relevant information and more automated features and use advanced digital techniques to enable a holistic digital solution for women with GDM.
{"title":"Quality and Multifunctionality in Mobile Apps for Gestational Diabetes: Systematic App Review.","authors":"Qimeng Zhao, Alison Cooke, Lishan Huang, Yimin Tang, Dawn Dowding","doi":"10.2196/76862","DOIUrl":"10.2196/76862","url":null,"abstract":"<p><strong>Background: </strong>The use of mobile health (mHealth) apps can assist with the management of gestational diabetes (GDM). Although a number of studies have demonstrated their efficacy in improving maternal-fetal outcomes, opinions differ regarding their usability and overall quality. Poorly designed apps, with ill-conceived features or inappropriate content, may pose a threat to patient safety. Nevertheless, very few studies provide in-depth evaluations of app design quality, and the diversity of features and techniques used remains insufficiently explored.</p><p><strong>Objective: </strong>We aimed to evaluate the quality and multifunctionality of commercially available mHealth apps for GDM.</p><p><strong>Methods: </strong>This is a systematic app review guided by the TECH (target user, evaluation focus, connectedness, and health domain) framework and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 checklist. Searches were conducted on the Apple App Store and Google Play. Apps were screened by name, description, and full navigation to identify inclusions. The quality of the apps was evaluated using the Mobile App Rating Scale and IMS Institute for Healthcare Informatics Functionality Score. Multifunctionality of the apps was evaluated using the GDM-adapted features and techniques list developed from the App Behavior Change Scale, NICE (National Institute for Health and Care Excellence) 2015 guidelines, and previous studies. The general features list, which contains instruction, data security, customization, and technical issues, was derived from previous studies.</p><p><strong>Results: </strong>The search (June 2024) identified 23 commercially available apps from UK app stores. The overall app quality was evaluated to be satisfactory (Mobile App Rating Scale: mean 4.0, SD 0.36; IMS Institute for Healthcare Informatics Functionality Score: mean 5.83, SD 3.03). The multifunctionality evaluation found that the apps had a mean of 17.95 and SD of 7.31 across all 45 items. Overall, our findings suggested that mHealth apps for GDM achieved a certain level of multifunctionality. However, their feature types and supporting digital techniques are relatively basic. The apps focused on education and managing blood glucose control rather than integrating other self-monitoring data and pregnancy-relevant management into their design. The digital techniques used to achieve these features included text and manual operation, rather than other automated features.</p><p><strong>Conclusions: </strong>This is the first app review to consider the relationship between app features and usability for women with GDM. Future app development should integrate a wide range of pregnancy-relevant information and more automated features and use advanced digital techniques to enable a holistic digital solution for women with GDM.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e76862"},"PeriodicalIF":6.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jong Yun Baek, Haeyoung Kim, Won Kyung Cho, Nalee Kim, Tae Hoon Lee, Won Chul Cha
<p><strong>Background: </strong>Integrating electronic patient-reported outcomes (ePROs) into electronic health records (EHRs) can enhance the quality of patient care. However, collecting longitudinal ePRO data throughout treatment and posttreatment surveillance remains challenging in patients with breast cancer. To address this, we implemented an automated system that enables ePRO acquisition and seamless integration into the EHR. The system delivers questionnaire weblinks via a mobile messaging app, allowing patients to complete ePROs before clinic visits, with responses automatically transferred to the EHR.</p><p><strong>Objective: </strong>This study aimed to assess patient response rates to the ePRO system and identify key factors influencing the response rate among patients with breast cancer who received radiotherapy and postradiotherapy follow-up.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of prospectively collected ePRO data by using the BREAST-Q questionnaire, a validated patient-reported outcome measure for breast surgery, from patients who received adjuvant radiotherapy at our institution between May 2023 and April 2024. At a preradiotherapy or postradiotherapy visit, each patient was asked to complete the questionnaire via a weblink sent to their mobile messaging app, KakaoTalk. The questionnaire was dispatched from minutes to several days before each visit. The response rate was calculated as the percentage of patients whose responses were successfully recorded in the EHR among those who were requested to respond. A complete response (CR) was defined as completion of all required questionnaire items. CR rates were analyzed according to clinical factors using univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Data from 1488 patients were analyzed, encompassing 2431 encounters (median 1, IQR 1-2 per patient). The median age of the patients was 51 (range 23-83) years, with 65.1% (n=968) patients aged 40 to 59 years. Comorbidities were present in 15% (223/1488) of the patients. The CR rate for the first, second, and third ePRO encounters was 89.9% (1338/1488), 98.3% (735/748), and 97.3% (180/185), respectively. Among first-time respondents, younger patients had a significantly higher CR rate (patients aged <60 years: 100/1104, 90.9%; patients aged ≥60 years: 334/384, 87%; P=.03). The timing of the questionnaire dispatch also affected the CR rate (P<.001). The CR rate was the highest when questionnaires were sent more than 1 hour before the visit (547/583, 93.3%) or in the afternoon of the previous day (505/545, 92.7%) and the lowest when sent 2 or more days before (100/130, 76.9%) or within 1 hour before the appointment (92/112, 81.7%). Both age (P=.006) and timing (P<.001) remained significant in the multivariate analysis.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of integrating ePRO into EHR through a mobile messaging app-based system, with high
{"title":"Evaluating the Feasibility of an Electronic Patient-Reported Outcomes Platform Integrating Electronic Health Records and a Mobile Messaging App in Breast Cancer Radiotherapy: Retrospective Cross-Sectional Study.","authors":"Jong Yun Baek, Haeyoung Kim, Won Kyung Cho, Nalee Kim, Tae Hoon Lee, Won Chul Cha","doi":"10.2196/67514","DOIUrl":"https://doi.org/10.2196/67514","url":null,"abstract":"<p><strong>Background: </strong>Integrating electronic patient-reported outcomes (ePROs) into electronic health records (EHRs) can enhance the quality of patient care. However, collecting longitudinal ePRO data throughout treatment and posttreatment surveillance remains challenging in patients with breast cancer. To address this, we implemented an automated system that enables ePRO acquisition and seamless integration into the EHR. The system delivers questionnaire weblinks via a mobile messaging app, allowing patients to complete ePROs before clinic visits, with responses automatically transferred to the EHR.</p><p><strong>Objective: </strong>This study aimed to assess patient response rates to the ePRO system and identify key factors influencing the response rate among patients with breast cancer who received radiotherapy and postradiotherapy follow-up.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of prospectively collected ePRO data by using the BREAST-Q questionnaire, a validated patient-reported outcome measure for breast surgery, from patients who received adjuvant radiotherapy at our institution between May 2023 and April 2024. At a preradiotherapy or postradiotherapy visit, each patient was asked to complete the questionnaire via a weblink sent to their mobile messaging app, KakaoTalk. The questionnaire was dispatched from minutes to several days before each visit. The response rate was calculated as the percentage of patients whose responses were successfully recorded in the EHR among those who were requested to respond. A complete response (CR) was defined as completion of all required questionnaire items. CR rates were analyzed according to clinical factors using univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Data from 1488 patients were analyzed, encompassing 2431 encounters (median 1, IQR 1-2 per patient). The median age of the patients was 51 (range 23-83) years, with 65.1% (n=968) patients aged 40 to 59 years. Comorbidities were present in 15% (223/1488) of the patients. The CR rate for the first, second, and third ePRO encounters was 89.9% (1338/1488), 98.3% (735/748), and 97.3% (180/185), respectively. Among first-time respondents, younger patients had a significantly higher CR rate (patients aged <60 years: 100/1104, 90.9%; patients aged ≥60 years: 334/384, 87%; P=.03). The timing of the questionnaire dispatch also affected the CR rate (P<.001). The CR rate was the highest when questionnaires were sent more than 1 hour before the visit (547/583, 93.3%) or in the afternoon of the previous day (505/545, 92.7%) and the lowest when sent 2 or more days before (100/130, 76.9%) or within 1 hour before the appointment (92/112, 81.7%). Both age (P=.006) and timing (P<.001) remained significant in the multivariate analysis.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility of integrating ePRO into EHR through a mobile messaging app-based system, with high","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e67514"},"PeriodicalIF":6.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark S Dworkin, Kara Herrera, Sierra Upton, Casey M Luc, Jeb Jones, Paul Burns, Li Liu, Antonio Jimenez, Ruiqi Ren, Meaghan Woody, Robert Garofalo, Sangyoon Lee
<p><strong>Background: </strong>Young African American men who have sex with men (AAMSM) experience disproportionately high HIV incidence and are less likely to achieve viral suppression compared to White men who have sex with men, an outcome that relies on antiretroviral therapy (ART) adherence. We created My Personal Health Guide, a talking relational agent-based mobile health app to improve ART adherence among young AAMSM.</p><p><strong>Objective: </strong>The objective was to determine the efficacy of My Personal Health Guide on improving ART adherence among young AAMSM living with HIV.</p><p><strong>Methods: </strong>We implemented a randomized controlled trial among young (aged 18-34 years) AAMSM with nonoptimal ART adherence throughout the United States between February 2020 and September 2023, predominantly through social media and by word of mouth, provider referral, and fliers in selected health care settings. Participants were randomized in a 1:1 ratio using permuted blocks of 8 to the intervention, My Personal Health Guide, or the attention control arm. ART adherence was assessed with Wilson's 3-item self-reported adherence measurement and dichotomized at ≥80%. Logistic regression models using backward selection were used to evaluate the efficacy of My Personal Health Guide on ≥80% ART adherence at 1-month follow-up.</p><p><strong>Results: </strong>Among the 253 AAMSM at baseline, most (n=180, 71.1%) self-reported being ≥80% adherent to ART, over half (n=145, 57.3%) resided in the Southern United States, but all US regions were represented, nearly half (n=175, 42.3%) had some college education, over one-third (n=96, 37.9%) had less than optimal literacy, and approximately one-quarter (n=61, 24.1%) experienced housing insecurity in the past 6 months. The sample for analysis of the My Personal Health Guide app efficacy was 131 (intervention=76 and control=55). The odds of being ≥80% adherent to ART at 1-month follow-up were 3.97 (95% CI 1.26-12.55) times greater among participants randomized to the My Personal Health Guide app compared to the controls, after adjusting for ART adherence at baseline, treatment adherence self-efficacy, and ever being incarcerated. Additionally, for every 1-point increase in the HIV Treatment Adherence Self-Efficacy Scale, the odds of ≥80% ART adherence increased by 3% (odds ratio 1.03, 95% CI 1.00-1.06).</p><p><strong>Conclusions: </strong>Participants randomized to receive My Personal Health Guide reported nearly 4 times greater odds of being ≥80% adherent to ART compared to the attention control group at 1-month follow-up. To our knowledge, this is the first randomized controlled trial demonstrating improved medication adherence using a relational agent-based behavioral intervention. These findings provide evidence of short-term efficacy of My Personal Health Guide to improve ART adherence among young AAMSM. We recommend further research on the inclusion of relational agents in behavioral research, espec
背景:年轻的非洲裔美国男男性行为者(AAMSM)经历了不成比例的高艾滋病毒发病率,与白人男男性行为者相比,病毒抑制的可能性更小,这一结果依赖于抗逆转录病毒治疗(ART)的坚持。我们创建了我的个人健康指南,这是一个会说话的基于关系代理的移动健康应用程序,旨在提高年轻的AAMSM对抗逆转录病毒治疗的依从性。目的:目的是确定我的个人健康指南在提高艾滋病毒感染的年轻男男性行为者抗逆转录病毒治疗依从性方面的功效。方法:我们在2020年2月至2023年9月期间在美国各地的非最佳ART依从性的年轻(18-34岁)AAMSM中实施了一项随机对照试验,主要通过社交媒体和口口相传,提供者推荐和选定医疗机构的传单。参与者以1:1的比例随机分配,使用8个排列块进行干预,我的个人健康指南或注意力控制臂。采用Wilson的3项自我报告依从性测量法评估ART依从性,并在≥80%时进行二分类。采用Logistic回归模型进行逆向选择,评估《我的个人健康指南》在随访1个月时ART依从性≥80%的疗效。结果:在基线的253名AAMSM中,大多数(n=180, 71.1%)自我报告的ART依从率≥80%,超过一半(n=145, 57.3%)居住在美国南部,但所有美国地区都有代表,近一半(n=175, 42.3%)接受过大学教育,超过三分之一(n=96, 37.9%)的识字率低于最佳水平,约四分之一(n=61, 24.1%)在过去6个月内经历过住房不安全。用于分析My Personal Health Guide应用程序功效的样本为131(干预=76,对照组=55)。在调整基线ART依从性、治疗依从性自我效能和曾经入狱后,随机分配到My Personal Health Guide应用程序的参与者在1个月随访时ART依从性≥80%的几率是对照组的3.97倍(95% CI 1.26-12.55)。此外,HIV治疗依从性自我效能量表每增加1分,ART依从性≥80%的几率增加3%(优势比1.03,95% CI 1.00-1.06)。结论:在1个月的随访中,随机接受“我的个人健康指南”的参与者报告的ART依从率≥80%的几率是注意力对照组的近4倍。据我们所知,这是第一个随机对照试验,证明使用基于关系代理的行为干预可以改善药物依从性。这些发现为“我的个人健康指南”提高年轻AAMSM的抗逆转录病毒治疗依从性的短期疗效提供了证据。我们建议进一步研究在行为研究中纳入关系因子,特别是在受污名和非最佳健康素养影响的人群中,这种非人类的支持和教育方法可能是卫生保健系统的补充。试验注册:ClinicalTrials.gov NCT04217174;https://clinicaltrials.gov/study/NCT04217174。
{"title":"Evidence of Efficacy of the My Personal Health Guide Mobile Phone App on Antiretroviral Therapy Adherence Among Young African American Men Who Have Sex With Men at 1 Month: Randomized Controlled Trial.","authors":"Mark S Dworkin, Kara Herrera, Sierra Upton, Casey M Luc, Jeb Jones, Paul Burns, Li Liu, Antonio Jimenez, Ruiqi Ren, Meaghan Woody, Robert Garofalo, Sangyoon Lee","doi":"10.2196/75005","DOIUrl":"https://doi.org/10.2196/75005","url":null,"abstract":"<p><strong>Background: </strong>Young African American men who have sex with men (AAMSM) experience disproportionately high HIV incidence and are less likely to achieve viral suppression compared to White men who have sex with men, an outcome that relies on antiretroviral therapy (ART) adherence. We created My Personal Health Guide, a talking relational agent-based mobile health app to improve ART adherence among young AAMSM.</p><p><strong>Objective: </strong>The objective was to determine the efficacy of My Personal Health Guide on improving ART adherence among young AAMSM living with HIV.</p><p><strong>Methods: </strong>We implemented a randomized controlled trial among young (aged 18-34 years) AAMSM with nonoptimal ART adherence throughout the United States between February 2020 and September 2023, predominantly through social media and by word of mouth, provider referral, and fliers in selected health care settings. Participants were randomized in a 1:1 ratio using permuted blocks of 8 to the intervention, My Personal Health Guide, or the attention control arm. ART adherence was assessed with Wilson's 3-item self-reported adherence measurement and dichotomized at ≥80%. Logistic regression models using backward selection were used to evaluate the efficacy of My Personal Health Guide on ≥80% ART adherence at 1-month follow-up.</p><p><strong>Results: </strong>Among the 253 AAMSM at baseline, most (n=180, 71.1%) self-reported being ≥80% adherent to ART, over half (n=145, 57.3%) resided in the Southern United States, but all US regions were represented, nearly half (n=175, 42.3%) had some college education, over one-third (n=96, 37.9%) had less than optimal literacy, and approximately one-quarter (n=61, 24.1%) experienced housing insecurity in the past 6 months. The sample for analysis of the My Personal Health Guide app efficacy was 131 (intervention=76 and control=55). The odds of being ≥80% adherent to ART at 1-month follow-up were 3.97 (95% CI 1.26-12.55) times greater among participants randomized to the My Personal Health Guide app compared to the controls, after adjusting for ART adherence at baseline, treatment adherence self-efficacy, and ever being incarcerated. Additionally, for every 1-point increase in the HIV Treatment Adherence Self-Efficacy Scale, the odds of ≥80% ART adherence increased by 3% (odds ratio 1.03, 95% CI 1.00-1.06).</p><p><strong>Conclusions: </strong>Participants randomized to receive My Personal Health Guide reported nearly 4 times greater odds of being ≥80% adherent to ART compared to the attention control group at 1-month follow-up. To our knowledge, this is the first randomized controlled trial demonstrating improved medication adherence using a relational agent-based behavioral intervention. These findings provide evidence of short-term efficacy of My Personal Health Guide to improve ART adherence among young AAMSM. We recommend further research on the inclusion of relational agents in behavioral research, espec","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e75005"},"PeriodicalIF":6.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivan Liu, Luming Hu, Jing Luo, Chang Liu, Qi Zhong, Shiguang Ni
<p><strong>Background: </strong>Pulse characteristics are well-established biomarkers of physical health; however, their relevance to psychological well-being remains insufficiently explored. A key barrier is the difficulty of acquiring pulse recordings of adequate quality outside clinical or laboratory settings using accessible measurement approaches.</p><p><strong>Objective: </strong>This study aimed to examine the feasibility of using smartphone photoplethysmography (PPG) to extract fingertip pulse-waveform features and to evaluate their associations with psychological measures. It further aimed to systematically compare time-, curvature-, and frequency-domain pulse-waveform features in relation to psychological variables.</p><p><strong>Methods: </strong>A total of 127 students and university employees in Shenzhen, China, were recruited. Participants recorded repeated 4-minute fingertip videos using a custom smartphone application while an FDA-cleared fingertip oximeter simultaneously acquired reference pulse signals. Smartphone videos were converted into PPG signals, segmented into beat-to-beat intervals, and summarized into time-, curvature-, and frequency-domain features using median values, with normalization for heart rate and stature. Psychological well-being and mental health were assessed using the Satisfaction With Life Scale (SWLS), Subjective Vitality Scale (SVS), Positive and Negative Affect Schedule (PANAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Self-Assessment Manikin (SAM). Associations between pulse-waveform features and psychological measures were examined using univariate regression with participant-level aggregation and cluster-robust standard errors. Random forest models evaluated multivariate predictive performance using participant-level cross-validation. Agreement between smartphone-derived and oximeter-derived waveform features was assessed using Bland-Altman analysis.</p><p><strong>Results: </strong>Correlation analyses revealed strong within-domain associations among time-, curvature-, and frequency-domain pulse-waveform features, with comparatively weaker cross-domain correlations. A correlation-based feature-selection procedure reduced multicollinearity and yielded a final set of seven features (ERI, CT, F/A, H/A, rPSD1, V0, and SBP). Univariate regression analyses indicated that negative psychological states were primarily associated with time- and curvature-domain features. Depressive symptoms were significantly related to F/A and V0, with ERI remaining significant after Bonferroni correction. Generalized anxiety showed a Bonferroni-corrected association with F/A, and negative affect was associated with CT and F/A. In contrast, positive affect measures showed fewer and weaker associations. Momentary valence was related to F/A and H/A, whereas arousal was associated with CT and H/A. Random forest models demonstrated statistically significant but modest predictive pe
{"title":"A Finger on the Pulse of Happiness: A Pilot Study Assessing Mental Health Using Smartphone Photoplethysmography-Based Digital Pulse Waveform Analysis.","authors":"Ivan Liu, Luming Hu, Jing Luo, Chang Liu, Qi Zhong, Shiguang Ni","doi":"10.2196/81301","DOIUrl":"https://doi.org/10.2196/81301","url":null,"abstract":"<p><strong>Background: </strong>Pulse characteristics are well-established biomarkers of physical health; however, their relevance to psychological well-being remains insufficiently explored. A key barrier is the difficulty of acquiring pulse recordings of adequate quality outside clinical or laboratory settings using accessible measurement approaches.</p><p><strong>Objective: </strong>This study aimed to examine the feasibility of using smartphone photoplethysmography (PPG) to extract fingertip pulse-waveform features and to evaluate their associations with psychological measures. It further aimed to systematically compare time-, curvature-, and frequency-domain pulse-waveform features in relation to psychological variables.</p><p><strong>Methods: </strong>A total of 127 students and university employees in Shenzhen, China, were recruited. Participants recorded repeated 4-minute fingertip videos using a custom smartphone application while an FDA-cleared fingertip oximeter simultaneously acquired reference pulse signals. Smartphone videos were converted into PPG signals, segmented into beat-to-beat intervals, and summarized into time-, curvature-, and frequency-domain features using median values, with normalization for heart rate and stature. Psychological well-being and mental health were assessed using the Satisfaction With Life Scale (SWLS), Subjective Vitality Scale (SVS), Positive and Negative Affect Schedule (PANAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Self-Assessment Manikin (SAM). Associations between pulse-waveform features and psychological measures were examined using univariate regression with participant-level aggregation and cluster-robust standard errors. Random forest models evaluated multivariate predictive performance using participant-level cross-validation. Agreement between smartphone-derived and oximeter-derived waveform features was assessed using Bland-Altman analysis.</p><p><strong>Results: </strong>Correlation analyses revealed strong within-domain associations among time-, curvature-, and frequency-domain pulse-waveform features, with comparatively weaker cross-domain correlations. A correlation-based feature-selection procedure reduced multicollinearity and yielded a final set of seven features (ERI, CT, F/A, H/A, rPSD1, V0, and SBP). Univariate regression analyses indicated that negative psychological states were primarily associated with time- and curvature-domain features. Depressive symptoms were significantly related to F/A and V0, with ERI remaining significant after Bonferroni correction. Generalized anxiety showed a Bonferroni-corrected association with F/A, and negative affect was associated with CT and F/A. In contrast, positive affect measures showed fewer and weaker associations. Momentary valence was related to F/A and H/A, whereas arousal was associated with CT and H/A. Random forest models demonstrated statistically significant but modest predictive pe","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Garlene Zamora Zamorano, Alejandro Déniz-García, Alezandra Torres-Castaño, María Luisa Álvarez-Malé, Inger Torhild Gram, Guri Skeie, Ana M Wägner
Background: Mobile apps are being increasingly used to foster healthy lifestyles. There is a growing need for clear, standardized guidelines to help users select safe and effective health apps.
Objective: Our study aimed to highlight the importance of establishing a structured framework for quality evaluation in mobile health (mHealth) through a case study of mobile apps promoting healthy eating.
Methods: We conducted a systematic review of apps promoting healthy eating that had already been evaluated by one or more of 28 recognized health app certification bodies. Three rounds of app evaluations were conducted by experts in nutrition and behavior change. The first two rounds focused on the quality of the content of the recommendations and were performed pairwise using the Quality Evaluation Scoring Tool (QUEST), which has not been previously used by the certification bodies. In addition, in the second and third rounds, each reviewer answered the question "How probable is it that you would recommend this app?" using a subjective scale score from 0 to 10. In the third round, this score was weighed by usability (30%), content quality (40%), and promotion of behavior change (30%). Discussions were held to resolve scoring discrepancies and to identify the top-quality apps. We also assessed correlations among QUEST, Google Play Store, and certification body scores.
Results: Of the 41 apps identified by five certification bodies, 19 (46.3%) met the inclusion criteria and were examined. Only 16 (84.2%) of these remained accessible for the second round. Eight of these surpassed 20 points (out of a maximum of 28) on the QUEST scale and were evaluated by all six experts in the third round, and the top 5 (62.5%) apps were selected. No correlations were found among QUEST, Google Play Store, and certification body scores.
Conclusions: Despite numerous evaluations by various certification bodies, only 5 (12.2%) of the 41 apps met the quality standards set by our experts. Our results mark the importance of rigorous, transparent, and standardized app evaluation processes to guide users toward making informed decisions about health apps. Guidelines for developers for the design of evidence-based, unbiased, high-quality apps, as well as technological solutions for real-time monitoring of the health apps, would address these challenges and improve reliability.
{"title":"The Landscape of Mobile Apps for Healthy Eating: Case Study for a Systematic Review and Quality Assessment.","authors":"Garlene Zamora Zamorano, Alejandro Déniz-García, Alezandra Torres-Castaño, María Luisa Álvarez-Malé, Inger Torhild Gram, Guri Skeie, Ana M Wägner","doi":"10.2196/68737","DOIUrl":"https://doi.org/10.2196/68737","url":null,"abstract":"<p><strong>Background: </strong>Mobile apps are being increasingly used to foster healthy lifestyles. There is a growing need for clear, standardized guidelines to help users select safe and effective health apps.</p><p><strong>Objective: </strong>Our study aimed to highlight the importance of establishing a structured framework for quality evaluation in mobile health (mHealth) through a case study of mobile apps promoting healthy eating.</p><p><strong>Methods: </strong>We conducted a systematic review of apps promoting healthy eating that had already been evaluated by one or more of 28 recognized health app certification bodies. Three rounds of app evaluations were conducted by experts in nutrition and behavior change. The first two rounds focused on the quality of the content of the recommendations and were performed pairwise using the Quality Evaluation Scoring Tool (QUEST), which has not been previously used by the certification bodies. In addition, in the second and third rounds, each reviewer answered the question \"How probable is it that you would recommend this app?\" using a subjective scale score from 0 to 10. In the third round, this score was weighed by usability (30%), content quality (40%), and promotion of behavior change (30%). Discussions were held to resolve scoring discrepancies and to identify the top-quality apps. We also assessed correlations among QUEST, Google Play Store, and certification body scores.</p><p><strong>Results: </strong>Of the 41 apps identified by five certification bodies, 19 (46.3%) met the inclusion criteria and were examined. Only 16 (84.2%) of these remained accessible for the second round. Eight of these surpassed 20 points (out of a maximum of 28) on the QUEST scale and were evaluated by all six experts in the third round, and the top 5 (62.5%) apps were selected. No correlations were found among QUEST, Google Play Store, and certification body scores.</p><p><strong>Conclusions: </strong>Despite numerous evaluations by various certification bodies, only 5 (12.2%) of the 41 apps met the quality standards set by our experts. Our results mark the importance of rigorous, transparent, and standardized app evaluation processes to guide users toward making informed decisions about health apps. Guidelines for developers for the design of evidence-based, unbiased, high-quality apps, as well as technological solutions for real-time monitoring of the health apps, would address these challenges and improve reliability.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e68737"},"PeriodicalIF":6.2,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Meng, Fengyan Fan, Yumei Ma, Nong Yan, Huan Wang, Zhen Zhang, Yiting Wang, Hailong Dong, Huang Nie
Background: Enhanced recovery after surgery (ERAS) guidelines recommend early postoperative mobilization to reduce complications, but adherence is often suboptimal, highlighting the need for effective tools to monitor and encourage movement. The Mindray enhanced patient monitoring (ePM)/electrophysiology (ep) pod, capable of tracking activity, vital signs, sleep, and pain, offers high-precision postoperative monitoring and is well-suited for research on activity feedback.
Objective: The study aims to assess whether wearable device-based (ePM/ep pod) activity feedback could reduce postoperative complications within 30 days of colorectal cancer (CRC) surgery.
Methods: We conducted an open-label, evaluator-blind, randomized controlled trial involving patients aged ≥18 years scheduled for CRC surgery. Patients were randomized to a feedback group or a control group. Both groups were set the same target activity time postoperatively based on ERAS guidelines. The feedback group received real-time visual feedback of movement time daily through the ePM/ep pod device, while the control group did not receive feedback. The primary outcome was the comprehensive complication index (CCI) within postoperative 30 days. Secondary outcomes included daily activity time, pain Numeric Rating Scale scores for rest and movement during the first 3 postoperative days, length of stay, percentage of reaching the scheduled mobilization target, 30-day postoperative mortality rate, and the times of first exhaust and defecation.
Results: Two hundred thirty-nine patients were recruited between February 2023 and September 2023, with 216 randomized (n=108 for each group). There was no significant difference in CCI within 30 postoperative days between the control group (median CCI 0, range 0-20.90) and the activity feedback group (median CCI 0, range 0-12.20). The estimated mean difference was -0.59 (95% CI -3.56 to 2.38; P=.66). Sensitivity analysis excluding patients with low device compliance did not alter these findings. No significant differences between groups were found in daily activity time, length of hospital stay, or pain scores. Post hoc analysis revealed significant negative correlations between 30-day CCI and activity on the second day after operation (r=-0.166) and the third day after operation (POD3) (r=-0.264; P<.05 for both). Linear regression indicated that POD3 activity significantly reduced CCI (β=-.025; 95% CI -0.045 to -0.006; P=.01), with peak CCI reduction at 215 minutes of activity.
Conclusions: In the context of ERAS, this study found no evidence that activity stimulation based on feedback from the wearable device (ePM/ep pod) could reduce 30-day postoperative CCI in patients undergoing CRC surgery. However, the ePM/ep pod could accurately record daily activity duration, which may be negatively correlated with CCI on POD3.
{"title":"Impact of Mobilization Facilitated by Wearable Device Enhanced Patient Monitoring/Electrophysiology Pod-Based Feedback on Postoperative Complications Following Colorectal Cancer Surgery: Randomized Controlled Trial.","authors":"Yang Meng, Fengyan Fan, Yumei Ma, Nong Yan, Huan Wang, Zhen Zhang, Yiting Wang, Hailong Dong, Huang Nie","doi":"10.2196/70534","DOIUrl":"10.2196/70534","url":null,"abstract":"<p><strong>Background: </strong>Enhanced recovery after surgery (ERAS) guidelines recommend early postoperative mobilization to reduce complications, but adherence is often suboptimal, highlighting the need for effective tools to monitor and encourage movement. The Mindray enhanced patient monitoring (ePM)/electrophysiology (ep) pod, capable of tracking activity, vital signs, sleep, and pain, offers high-precision postoperative monitoring and is well-suited for research on activity feedback.</p><p><strong>Objective: </strong>The study aims to assess whether wearable device-based (ePM/ep pod) activity feedback could reduce postoperative complications within 30 days of colorectal cancer (CRC) surgery.</p><p><strong>Methods: </strong>We conducted an open-label, evaluator-blind, randomized controlled trial involving patients aged ≥18 years scheduled for CRC surgery. Patients were randomized to a feedback group or a control group. Both groups were set the same target activity time postoperatively based on ERAS guidelines. The feedback group received real-time visual feedback of movement time daily through the ePM/ep pod device, while the control group did not receive feedback. The primary outcome was the comprehensive complication index (CCI) within postoperative 30 days. Secondary outcomes included daily activity time, pain Numeric Rating Scale scores for rest and movement during the first 3 postoperative days, length of stay, percentage of reaching the scheduled mobilization target, 30-day postoperative mortality rate, and the times of first exhaust and defecation.</p><p><strong>Results: </strong>Two hundred thirty-nine patients were recruited between February 2023 and September 2023, with 216 randomized (n=108 for each group). There was no significant difference in CCI within 30 postoperative days between the control group (median CCI 0, range 0-20.90) and the activity feedback group (median CCI 0, range 0-12.20). The estimated mean difference was -0.59 (95% CI -3.56 to 2.38; P=.66). Sensitivity analysis excluding patients with low device compliance did not alter these findings. No significant differences between groups were found in daily activity time, length of hospital stay, or pain scores. Post hoc analysis revealed significant negative correlations between 30-day CCI and activity on the second day after operation (r=-0.166) and the third day after operation (POD3) (r=-0.264; P<.05 for both). Linear regression indicated that POD3 activity significantly reduced CCI (β=-.025; 95% CI -0.045 to -0.006; P=.01), with peak CCI reduction at 215 minutes of activity.</p><p><strong>Conclusions: </strong>In the context of ERAS, this study found no evidence that activity stimulation based on feedback from the wearable device (ePM/ep pod) could reduce 30-day postoperative CCI in patients undergoing CRC surgery. However, the ePM/ep pod could accurately record daily activity duration, which may be negatively correlated with CCI on POD3.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e70534"},"PeriodicalIF":6.2,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Adolescents from underserved communities, particularly Black and Hispanic youth, engage in lower levels of physical activity (PA), increasing their risk for chronic disease. Conventional interventions often face barriers such as limited access to safe environments. Wearable mobile health technologies offer scalable and context-sensitive solutions; however, predictors of sustained adherence in school-based settings among high-risk populations remain underexplored.
Objective: This study aims to examine the behavioral and contextual predictors of adherence to a consumer-grade wearable PA tracker among underserved high school students.
Methods: In this school-based observational study, 63 students (mean age 14.8, SD 1.17 years) enrolled in physical education received Fitbit devices. Adherence was defined as ≥21 valid days of step count data. Measures included self-reported PA behaviors, neighborhood perceptions, physical fitness (including anthropometrics), and device adherence. Group comparisons were conducted using t tests and chi-square tests. Logistic regression was used to identify predictors of adherence.
Results: Overall, 73% (46/63) of participants met the adherence threshold. Adherent students reported fewer days of moderate-to-vigorous PA (2 vs 4 days/week; P=.004), lower team sports participation (21/46, 46% vs 12/17, 71%; P=.004), and higher perceived neighborhood safety (P=.02). In adjusted models, lower PA frequency, greater perceived safety, and neighborhood walkability significantly predicted adherence (χ² 6=16.23; P=.01, Nagelkerke R²=0.61).
Conclusions: Wearable mobile health technologies show promise for engaging underserved adolescents in PA, particularly those with lower baseline activity and limited access to structured sports. Key predictors of adherence included perceived neighborhood walkability, team sports participation, and prior PA behavior. School-based deployment of wearable devices should emphasize personalized goals and autonomy-supportive strategies to foster sustained engagement and promote PA among high-risk youth.
{"title":"Assessing Wearable mHealth Adherence in Underserved Adolescents and its Associations With Physical Activity, Sports, and Safety Perceptions: Prospective Cohort Study.","authors":"Annabel Nunez-Gaunaurd, Michele Raya","doi":"10.2196/80465","DOIUrl":"10.2196/80465","url":null,"abstract":"<p><strong>Background: </strong>Adolescents from underserved communities, particularly Black and Hispanic youth, engage in lower levels of physical activity (PA), increasing their risk for chronic disease. Conventional interventions often face barriers such as limited access to safe environments. Wearable mobile health technologies offer scalable and context-sensitive solutions; however, predictors of sustained adherence in school-based settings among high-risk populations remain underexplored.</p><p><strong>Objective: </strong>This study aims to examine the behavioral and contextual predictors of adherence to a consumer-grade wearable PA tracker among underserved high school students.</p><p><strong>Methods: </strong>In this school-based observational study, 63 students (mean age 14.8, SD 1.17 years) enrolled in physical education received Fitbit devices. Adherence was defined as ≥21 valid days of step count data. Measures included self-reported PA behaviors, neighborhood perceptions, physical fitness (including anthropometrics), and device adherence. Group comparisons were conducted using t tests and chi-square tests. Logistic regression was used to identify predictors of adherence.</p><p><strong>Results: </strong>Overall, 73% (46/63) of participants met the adherence threshold. Adherent students reported fewer days of moderate-to-vigorous PA (2 vs 4 days/week; P=.004), lower team sports participation (21/46, 46% vs 12/17, 71%; P=.004), and higher perceived neighborhood safety (P=.02). In adjusted models, lower PA frequency, greater perceived safety, and neighborhood walkability significantly predicted adherence (χ² 6=16.23; P=.01, Nagelkerke R²=0.61).</p><p><strong>Conclusions: </strong>Wearable mobile health technologies show promise for engaging underserved adolescents in PA, particularly those with lower baseline activity and limited access to structured sports. Key predictors of adherence included perceived neighborhood walkability, team sports participation, and prior PA behavior. School-based deployment of wearable devices should emphasize personalized goals and autonomy-supportive strategies to foster sustained engagement and promote PA among high-risk youth.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e80465"},"PeriodicalIF":6.2,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12855722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Background: </strong>The global integration of telehealth into the management of Parkinson disease (PD) addresses critical gaps in health care access, especially for patients with limited mobility in underserved regions. Despite accelerated adoption during the COVID-19 pandemic, evidence regarding telehealth's multidimensional efficacy remains inconsistent. Previous meta-analyses reported conflicting outcomes for quality of life (QOL), motor symptoms, and neuropsychiatric comorbidities.</p><p><strong>Objective: </strong>This study aimed to quantitatively synthesize the effects of telehealth interventions across six core PD domains: (1) QOL, (2) depression, (3) anxiety, (4) motor symptoms, (5) activities of daily living (ADL), and (6) cognition.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, Scopus, and Web of Science were systematically searched until June 21, 2024. In adherence to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, English-language randomized controlled trials evaluating telehealth interventions for PD were included. Study quality was assessed using the Cochrane Risk of Bias tool. A dual analytical approach using random-effects models was applied to address heterogeneity. Studies reporting a single effect size were analyzed using the Hartung-Knapp-Sidik-Jonkman correction. Studies with multiple dependent effect sizes were analyzed using a 3-level random-effects meta-analysis with t-distribution inference, accounting for sampling, within-study, and between-study variance. Effect sizes were expressed as standardized mean differences (SMD) with 95% CIs. Heterogeneity was quantified using the τ<sup>2</sup>; prediction intervals were not calculated due to the limited number of studies. Prespecified subgroup analyses examined intervention types (digital vs traditional telehealth) and follow-up durations. Sensitivity analyses and assessments for small-study effects (multilevel Egger tests, funnel plots) were conducted.</p><p><strong>Results: </strong>A total of 15 randomized controlled trials (765 participants) demonstrated significant telehealth benefits: QOL significantly improved on the Medical Outcomes Study 36-Item Short Form Health Survey and Brunnsviken Brief Quality of Life Scale (SMD 0.39, 95% CI 0.06-0.72; P=.03), with marginal improvement on the Parkinson Disease Questionnaire-8 (SMD -0.42, 95% CI -0.88 to 0.03; P=.07). Telephone-based interventions outperformed digital approaches (P=.002). Depression symptoms were significantly reduced (SMD -0.64, 95% CI -0.93 to 0.34; P<.001), particularly with traditional telehealth (P<.001). Anxiety also decreased significantly (SMD -0.64, 95% CI -0.92 to 0.35; P=.003) with negligible heterogeneity (I<sup>2</sup>=0%). Motor symptoms improved (SMD -0.46, 95% CI -0.69 to 0.24; P=.001), and ADL showed substantial impairment reduction (SMD -0.79, 95% CI -1.04 to -0.54; P=.002). Cognition was significantly enhanced (SMD 1.12, 9
背景:全球将远程医疗整合到帕金森病(PD)的管理中,解决了卫生保健可及性方面的关键差距,特别是对服务不足地区行动不便的患者。尽管在2019冠状病毒病大流行期间加快了采用,但关于远程医疗多方面功效的证据仍然不一致。先前的荟萃分析报告了生活质量(QOL)、运动症状和神经精神合并症的相互矛盾的结果。目的:本研究旨在定量综合远程医疗干预对PD六个核心领域的影响:(1)生活质量,(2)抑郁,(3)焦虑,(4)运动症状,(5)日常生活活动(ADL)和(6)认知。方法:系统检索PubMed、Embase、Cochrane Library、Scopus、Web of Science,检索截止至2024年6月21日。遵循PRISMA(系统评价和荟萃分析首选报告项目)指南,纳入了评估PD远程医疗干预的英语随机对照试验。使用Cochrane偏倚风险工具评估研究质量。采用随机效应模型的双重分析方法来解决异质性。报告单一效应量的研究使用hartung - knap - sidik - jonkman校正进行分析。对具有多个依赖效应量的研究,采用具有t分布推断的3水平随机效应荟萃分析,考虑抽样、研究内和研究间方差。效应量以95% ci的标准化平均差异(SMD)表示。异质性用τ2量化;由于研究数量有限,未计算预测区间。预先指定的亚组分析检查了干预类型(数字与传统远程医疗)和随访时间。对小研究效应进行敏感性分析和评估(多水平Egger检验、漏斗图)。结果:共有15项随机对照试验(765名参与者)显示了显著的远程医疗益处:医疗结果研究36项简短健康调查和Brunnsviken简短生活质量量表(SMD - 0.39, 95% CI 0.06-0.72; P= 0.03)的生活质量显著改善,帕金森病问卷-8 (SMD -0.42, 95% CI -0.88 - 0.03; P= 0.07)的生活质量略有改善。基于电话的干预优于数字方法(P= 0.002)。抑郁症状明显减轻(SMD -0.64, 95% CI -0.93 ~ 0.34; P2=0%)。运动症状得到改善(SMD -0.46, 95% CI -0.69至0.24;P= 0.001), ADL表现出显著的损伤减轻(SMD -0.79, 95% CI -1.04至-0.54;P= 0.002)。尽管存在中度异质性(I2=52.3%)和显著的发表偏倚,但认知能力显著增强(SMD 1.12, 95% CI 0.03至2.20;P= 0.045)。结论:远程医疗干预显著增强多个PD域,传统(电话/平板电脑)方法在生活质量和抑郁方面表现出特殊优势。数字干预显示出更有限的效果。这些发现支持远程医疗作为帕金森病的多方面管理工具,尽管认知结果需要进一步调查。试验注册:PROSPERO CRD42024520169;https://www.crd.york.ac.uk/PROSPERO/view/CRD42024520169。
{"title":"Effects of Telehealth Interventions for People With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Minyue Sun, Fuyou Tang, Luo Min, Shiyu Wen, Shuang Wang, Huiping Jiang","doi":"10.2196/70994","DOIUrl":"https://doi.org/10.2196/70994","url":null,"abstract":"<p><strong>Background: </strong>The global integration of telehealth into the management of Parkinson disease (PD) addresses critical gaps in health care access, especially for patients with limited mobility in underserved regions. Despite accelerated adoption during the COVID-19 pandemic, evidence regarding telehealth's multidimensional efficacy remains inconsistent. Previous meta-analyses reported conflicting outcomes for quality of life (QOL), motor symptoms, and neuropsychiatric comorbidities.</p><p><strong>Objective: </strong>This study aimed to quantitatively synthesize the effects of telehealth interventions across six core PD domains: (1) QOL, (2) depression, (3) anxiety, (4) motor symptoms, (5) activities of daily living (ADL), and (6) cognition.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, Scopus, and Web of Science were systematically searched until June 21, 2024. In adherence to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, English-language randomized controlled trials evaluating telehealth interventions for PD were included. Study quality was assessed using the Cochrane Risk of Bias tool. A dual analytical approach using random-effects models was applied to address heterogeneity. Studies reporting a single effect size were analyzed using the Hartung-Knapp-Sidik-Jonkman correction. Studies with multiple dependent effect sizes were analyzed using a 3-level random-effects meta-analysis with t-distribution inference, accounting for sampling, within-study, and between-study variance. Effect sizes were expressed as standardized mean differences (SMD) with 95% CIs. Heterogeneity was quantified using the τ<sup>2</sup>; prediction intervals were not calculated due to the limited number of studies. Prespecified subgroup analyses examined intervention types (digital vs traditional telehealth) and follow-up durations. Sensitivity analyses and assessments for small-study effects (multilevel Egger tests, funnel plots) were conducted.</p><p><strong>Results: </strong>A total of 15 randomized controlled trials (765 participants) demonstrated significant telehealth benefits: QOL significantly improved on the Medical Outcomes Study 36-Item Short Form Health Survey and Brunnsviken Brief Quality of Life Scale (SMD 0.39, 95% CI 0.06-0.72; P=.03), with marginal improvement on the Parkinson Disease Questionnaire-8 (SMD -0.42, 95% CI -0.88 to 0.03; P=.07). Telephone-based interventions outperformed digital approaches (P=.002). Depression symptoms were significantly reduced (SMD -0.64, 95% CI -0.93 to 0.34; P<.001), particularly with traditional telehealth (P<.001). Anxiety also decreased significantly (SMD -0.64, 95% CI -0.92 to 0.35; P=.003) with negligible heterogeneity (I<sup>2</sup>=0%). Motor symptoms improved (SMD -0.46, 95% CI -0.69 to 0.24; P=.001), and ADL showed substantial impairment reduction (SMD -0.79, 95% CI -1.04 to -0.54; P=.002). Cognition was significantly enhanced (SMD 1.12, 9","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e70994"},"PeriodicalIF":6.2,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexios Dosis, Aron Berger Syversen, Mikolaj R Kowal, Daniel Grant, Jim Tiernan, David Wong, David G Jayne
Background: Current methods of cardiorespiratory fitness (CRF) assessment may discriminate against frail individuals who are challenged to perform a maximal cardiopulmonary exercise test. CRF estimations from free-living wearable data, captured over extended time periods, may offer a more representative assessment and increase usability in clinical settings.
Objective: This study aimed to review current evidence behind this novel concept and evaluate the performance and quality of models developed to estimate CRF from free-living, unsupervised data.
Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we systematically searched 4 databases (MEDLINE, Embase, Scopus, and arXiv) for studies reporting the development of models to estimate CRF from continuous free-living wearable data. Studies conducted entirely under controlled laboratory conditions were excluded. Performance metrics were combined in a meta-correlation analysis using a random-effects model and Fisher Z transformation.
Results: Of 1848 papers screened, 18 met the eligibility criteria, with a total of 31,072 participants. The weighted mean age was 46.9 (SD 1.46) years. Multiple computational techniques were used, with 8 studies employing more advanced machine learning models. The meta-correlation analysis revealed a pooled overall estimate of 0.83 with a 95% CI 0.77-0.88. The I2 test indicated high heterogeneity at 97%. Risk of bias assessment found most concerns in the data analysis domain, with studies often lacking clarity around the data handling process.
Conclusions: A promising preliminary agreement between CRF predictions and measured values was noted. However, no definite conclusions can be drawn for clinical implementation due to high heterogeneity among the included studies and lack of external validation. Nonetheless, continuous data streams appear to be a valuable resource that could lead to a step change in how we measure and monitor CRF.
{"title":"Exploiting Unsupervised Free-Living Data for Cardiorespiratory Fitness Estimation: Systematic Review and Meta-Analysis.","authors":"Alexios Dosis, Aron Berger Syversen, Mikolaj R Kowal, Daniel Grant, Jim Tiernan, David Wong, David G Jayne","doi":"10.2196/69996","DOIUrl":"10.2196/69996","url":null,"abstract":"<p><strong>Background: </strong>Current methods of cardiorespiratory fitness (CRF) assessment may discriminate against frail individuals who are challenged to perform a maximal cardiopulmonary exercise test. CRF estimations from free-living wearable data, captured over extended time periods, may offer a more representative assessment and increase usability in clinical settings.</p><p><strong>Objective: </strong>This study aimed to review current evidence behind this novel concept and evaluate the performance and quality of models developed to estimate CRF from free-living, unsupervised data.</p><p><strong>Methods: </strong>Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we systematically searched 4 databases (MEDLINE, Embase, Scopus, and arXiv) for studies reporting the development of models to estimate CRF from continuous free-living wearable data. Studies conducted entirely under controlled laboratory conditions were excluded. Performance metrics were combined in a meta-correlation analysis using a random-effects model and Fisher Z transformation.</p><p><strong>Results: </strong>Of 1848 papers screened, 18 met the eligibility criteria, with a total of 31,072 participants. The weighted mean age was 46.9 (SD 1.46) years. Multiple computational techniques were used, with 8 studies employing more advanced machine learning models. The meta-correlation analysis revealed a pooled overall estimate of 0.83 with a 95% CI 0.77-0.88. The I2 test indicated high heterogeneity at 97%. Risk of bias assessment found most concerns in the data analysis domain, with studies often lacking clarity around the data handling process.</p><p><strong>Conclusions: </strong>A promising preliminary agreement between CRF predictions and measured values was noted. However, no definite conclusions can be drawn for clinical implementation due to high heterogeneity among the included studies and lack of external validation. Nonetheless, continuous data streams appear to be a valuable resource that could lead to a step change in how we measure and monitor CRF.</p>","PeriodicalId":14756,"journal":{"name":"JMIR mHealth and uHealth","volume":"14 ","pages":"e69996"},"PeriodicalIF":6.2,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12841865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}