运动对饮食性肥胖大鼠FNDC5/鸢尾素通路影响的比较研究

Yong-Jin Kim, Tae-Dong Kwon
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摘要

本研究旨在观察运动对比对饮食性肥胖大鼠FNDC5 / irisin通路的影响。为了达到这个目的,我们给48只雄性Sprague-Dawley大鼠喂食高脂肪食物,并进行游泳运动和自愿运动,为期6周。与正常饮食对照组、正常饮食+游泳运动组、正常饮食+轮式跑步运动组、高脂饮食组、高脂饮食+游泳运动组、高脂饮食+轮式跑步运动组相比,各组pgc -1α表达均无显著差异,FNDC5表达均无显著差异。正常饮食+游泳运动组、正常饮食+轮式自主跑步运动组、高脂饮食组、高脂饮食+游泳运动组、高脂饮食+轮式自主跑步组鸢尾素显著降低。BR对于脂肪组织的变化,与正常饮食对照组、正常饮食+游泳运动组、正常饮食+轮式跑步运动组、高脂肪饮食组、高脂肪饮食+游泳运动组、高脂肪饮食+轮式跑步运动组相比,UCP-1表达量显著降低,PPAR-γ表达量与正常饮食对照组、正常饮食+游泳运动组、正常饮食+轮式跑步运动组、高脂肪饮食组相比,高脂饮食+游泳运动组、高脂饮食+轮式跑步运动组明显降低。因此,结果提示,在根据饮食和运动方法观察到的脂肪褐变中,饮食和定期耐力运动在控制脂肪褐变方面有积极的效果,基于运动机制和与各种饮食和运动方法相关的积极研究,可以分配少量的因素,如提高能量利用率和抗肥胖代谢综合征。
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The Comparison study of Exercise on FNDC5/irisin pathway in diet-induced obese rats
The purpose of this study is to observe the effect of Comparison of Exercise on FNDC5 / irisin pathway in diet-induced obese rats. To achieve this purpose, 48 male Sprague-Dawley rats were fed a high-fat diet and were subjected to swimming exercise and voluntary exercise for 6 weeks. Compared to normal diet control group, normal diet+swimming exercise group, normal diet+voluntary wheel running exercise group, high fat diet group, high fat diet+swimming exercise group, high fat diet+ voluntary wheel running exercise group PGC-1αexpression was no showed significantly, FNDC5 expression respectively group was no showed significantly. Irisin was significantly decreased in thenormal diet+swimming exercise group, normal diet+voluntary wheel running exercise group, high fat diet group, high fat diet+swimming exercise group, high fat diet+voluntary wheel running significantly decreased.BR For the change of adipose tissue, Compared to normal diet control group, normal diet+swimming exercise group, normal diet+voluntary wheel running exercise group, high fat diet group, high fat diet+swimming exercise group, high fat diet+voluntary wheel running exercise group UCP-1 expression was significantly decreased alos PPAR-γexpression was compared to normal diet control group, normal diet+swimming exercise group, normal diet+voluntary wheel running exercise group, high fat diet group, high fat diet+swimming exercise group, high fat diet+voluntary wheel running exercise group significantly decreased. Therefore, the results suggest that in the browning of observed fat according to the diet and exercise method, diet and regular endurance exercise present positive results in controlled fat browning, based on the exercise mechanism and active study in relation to various diet and exercise methods What can allocate a small number of factors such as increased utilization of energy and anti-obesity and metabolic syndrome are metabolized.
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