{"title":"MethylTree: exploring epimutations for accurate and non-invasive lineage tracing","authors":"","doi":"10.1038/s41592-024-02568-0","DOIUrl":null,"url":null,"abstract":"Non-invasive lineage tracing in humans relies on rare somatic mutations, which have limited throughput and temporal resolution. We developed a computational method, ‘MethylTree’, which uses epimutations on DNA methylation to accurately infer lineages across cell types, developmental stages and species, providing a superior alternative for non-invasive lineage tracing in humans and other organisms.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"22 3","pages":"463-464"},"PeriodicalIF":36.1000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-024-02568-0","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Non-invasive lineage tracing in humans relies on rare somatic mutations, which have limited throughput and temporal resolution. We developed a computational method, ‘MethylTree’, which uses epimutations on DNA methylation to accurately infer lineages across cell types, developmental stages and species, providing a superior alternative for non-invasive lineage tracing in humans and other organisms.
期刊介绍：
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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