Investigating social cognition in Multiple Sclerosis: Does Implicit Biological Motion processing affect visuo-spatial attention?

Abstract

The perception of Biological Motion (BM) is critical for understanding social cues. A limited number of moving light dots resembling a moving individual, can suggest social intention information, providing an attentional orienting. This ability to predict other's intentions from BM cues refers to social cognition, an ability impaired in several neurological diseases.

As in patients with Multiple Sclerosis (MS) an impairment in visuo-spatial attention and social cognition has been observed, we aim to investigate the possible differences in the visuo-spatial attention between MS patients and healthy individuals by using BM stimuli as cues.

We tested 37 MS patients and 40 healthy controls (HC), who performed a modified central cue Posner task, using BM stimuli as cues that are not always predictive of the target location. They were represented by Point Light Walker (PLW) configuration, a series of dots arranged at the human joints and walking through the left or right of the screen, shown in the global (whole body) or local (two dots, indicating the feet of the PLW) configuration.

MS patients exhibited overall slower responses compared to HC. In MS patients, a weaker advantage of valid trial over invalid ones was evident when cue had a local than global BM configuration. Also, MS patients showed a slower performance than HC in valid trials with local BM cues. The difference between groups was attenuated when the cue had a global BM configuration. These findings suggest possible impairment of local BM cue processing in MS patients, possibly due to delays or deficits in interpreting feet motion as biological information, reducing the cue's predictive power.