Neutrino mass origin remains one of the central unsolved puzzles in particle physics. Leading mechanisms were established by the early 2000s, with limited essential breakthroughs observed in the past twenty years. These approaches often rely on the unobserved Higgs triplet field, non-renormalizable operators or the hypothetical coupling of the left-handed and right-handed neutrinos. In this work, we address these fundamental challenges by proposing a novel low-scale mechanism where neutrino masses are generated through a renormalizable, Higgs doublet-mediated interaction between the SU(2) lepton doublet and the CP conjugate singlet, distinct from the conventional Higgs–Yukawa coupling formed between the lepton doublet and singlet. Through a fresh extension of the Standard Model (SM) where the SU(2) doublet and singlet representations of neutrinos are slightly misaligned with their chiral fields, we were able to provide a theoretically coherent explanation for the Majorana neutrino mass generation without a priori assumption that neutrinos are their own antiparticles. Our model further eliminates the coupling of the left-handed and right-handed neutrinos and meanwhile substantially reduces the fine-tuning of Yukawa couplings. We conclude by highlighting the key implications of our findings, including the minimal mixing between active and sterile neutrinos (consistent with current experiments) and the potential of the present SM extension in decoding the flavor mixing and CP-violating phases.