Background: Differentiating follicular thyroid carcinoma (FTC) from follicular adenoma (FA) is challenging due to their histological similarities. This systematic review and meta-analysis aimed to assess the difference in Ki-67 expression between FTC and FA to evaluate its diagnostic utility.
Methods: We conducted a comprehensive search of PubMed, Embase, Scopus, and Web of Science databases for studies reporting Ki-67 expression in FTC and FA. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. A random-effects model was applied to calculate the pooled mean difference of the Ki-67 index, with heterogeneity assessed by the Cochran Q and I-squared tests. Meta-regression was used to explore sources of heterogeneity, and publication bias was evaluated using Egger's test, Begg's test, and funnel plot.
Results: The meta-analysis revealed a pooled mean difference in Ki-67 expression between FTC and FA of 1.13 (0.63-1.63), indicating a significant difference. In addition, the difference in the Ki-67 index between minimally invasive follicular carcinoma and FA was 0.56 (0.12-1.00), which was also statistically significant. The heterogeneity among included studies was due to variations in Ki-67 index calculation methods. The reviewed studies demonstrated low sensitivity but high specificity of Ki-67 for differentiating FTC vs. FA, although diagnostic cut-offs were inconsistent.
Conclusions: This study demonstrates a significant difference in Ki-67 expression between FTC and FA, supporting its potential role as a diagnostic marker. Further research is required to establish standardized diagnostic cut-offs and evaluate Ki-67's sensitivity and specificity in clinical practice.
背景：区分滤泡性甲状腺癌（FTC）和滤泡性腺瘤（FA）是具有挑战性的，因为它们的组织学相似。本系统综述和荟萃分析旨在评估Ki-67表达在FTC和FA之间的差异，以评估其诊断价值。方法：我们对PubMed， Embase， Scopus和Web of Science数据库进行了全面的检索，以报告FTC和FA中Ki-67表达的研究。纳入研究的质量采用纽卡斯尔-渥太华量表进行评估。采用随机效应模型计算Ki-67指数的汇总均差，采用Cochran Q检验和i²检验评估异质性。meta回归分析异质性来源，发表偏倚评价采用Egger检验、Begg检验和漏斗图。结果：荟萃分析显示，FTC与FA之间Ki-67表达的汇总平均差异为1.13(0.63-1.63)，差异具有统计学意义。此外，微创滤泡癌与FA的Ki-67指数差异为0.56(0.12-1.00)，差异亦有统计学意义。纳入研究的异质性是由于Ki-67指数计算方法的差异。所回顾的研究表明，Ki-67在鉴别FTC和FA方面敏感性低，但特异性高，尽管诊断截止值不一致。结论：本研究表明Ki-67在FTC和FA之间的表达有显著差异，支持其作为诊断标志物的潜在作用。在临床实践中，需要进一步的研究来建立标准化的诊断临界值，并评估Ki-67的敏感性和特异性。
{"title":"Diagnostic role of Ki-67 expression in distinguishing thyroid follicular carcinoma from follicular adenoma: a systematic review and meta-analysis.","authors":"Rayehe Rahimi, Fakhrieh Kalavari, Yalda Ashoorian, Mohammad Amin Ashoobi, Enayatollah Homaie Rad, Saeid Anvari","doi":"10.1097/MS9.0000000000004503","DOIUrl":"10.1097/MS9.0000000000004503","url":null,"abstract":"<p><strong>Background: </strong>Differentiating follicular thyroid carcinoma (FTC) from follicular adenoma (FA) is challenging due to their histological similarities. This systematic review and meta-analysis aimed to assess the difference in Ki-67 expression between FTC and FA to evaluate its diagnostic utility.</p><p><strong>Methods: </strong>We conducted a comprehensive search of PubMed, Embase, Scopus, and Web of Science databases for studies reporting Ki-67 expression in FTC and FA. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. A random-effects model was applied to calculate the pooled mean difference of the Ki-67 index, with heterogeneity assessed by the Cochran <i>Q</i> and <i>I</i>-squared tests. Meta-regression was used to explore sources of heterogeneity, and publication bias was evaluated using Egger's test, Begg's test, and funnel plot.</p><p><strong>Results: </strong>The meta-analysis revealed a pooled mean difference in Ki-67 expression between FTC and FA of 1.13 (0.63-1.63), indicating a significant difference. In addition, the difference in the Ki-67 index between minimally invasive follicular carcinoma and FA was 0.56 (0.12-1.00), which was also statistically significant. The heterogeneity among included studies was due to variations in Ki-67 index calculation methods. The reviewed studies demonstrated low sensitivity but high specificity of Ki-67 for differentiating FTC vs. FA, although diagnostic cut-offs were inconsistent.</p><p><strong>Conclusions: </strong>This study demonstrates a significant difference in Ki-67 expression between FTC and FA, supporting its potential role as a diagnostic marker. Further research is required to establish standardized diagnostic cut-offs and evaluate Ki-67's sensitivity and specificity in clinical practice.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 2","pages":"1695-1705"},"PeriodicalIF":1.6,"publicationDate":"2026-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-11eCollection Date: 2026-02-01DOI: 10.1097/MS9.0000000000004561
Singam Shashank, Rashmikaa Netyam, Chiranjeevee R Saravanan, Nikhil D Kolanu, Nanditha Karra, Harshada S Keluskar, Ziad Helaly, Mohammed H Albitar, Abdullah Sharbek, Seba Albitar, Pugazhendi Inban, Mohammed D M Marsool, Omniat A Hussin
Background: Hybrid coronary revascularization (HCR), a combination of percutaneous coronary intervention and coronary artery bypass grafting (CABG), is an emerging treatment for patients with multivessel coronary artery disease (MVCAD). While traditional CABG is considered the standard, HCR may mitigate issues like saphenous vein graft failure.
Methods: We systematically searched PubMed, Scopus, Web of Science, and Embase until September 2024, targeting randomized controlled trials (RCTs) that evaluated HCR against CABG in MVCAD patients. The quality of included studies was assessed using the ROB2 tool, and data were analyzed using RevMan 5.4. Four RCTs (n = 382) involving 382 participants were analyzed using a random-effects model. Risk of bias was assessed using the ROB2 tool.
Results: Four RCTs (n = 382) met inclusion criteria. At 30 days, there were no statistically significant differences between HCR and CABG in all-cause death (risk ratios [RR] = 1.35, P = 0.74), stroke (RR = 0.99, P = 0.99), myocardial infarction (RR = 1.17, P = 0.74), or blood transfusion (RR = 0.70, P = 0.14), with zero heterogeneity (I2 = 0%). At 1-year follow-up, pooled analyses showed no significant differences in all-cause death (RR = 1.37, P = 0.62) or myocardial infarction (RR = 1.29, P = 0.56), also with consistent homogeneity (I2 = 0%).
Conclusion: HCR demonstrates comparable safety and effectiveness to CABG for MVCAD, with similar rates of key outcomes at both 30 days and 1 year. Further research with larger samples and longer follow-up is recommended to confirm these findings.
背景：混合冠状动脉血管重建术（HCR）是一种经皮冠状动脉介入治疗和冠状动脉旁路移植术（CABG）相结合的治疗方法，是治疗多支冠状动脉疾病（MVCAD）的新方法。虽然传统的冠脉搭桥被认为是标准的，但HCR可以减轻隐静脉移植失败等问题。方法：我们系统地检索PubMed， Scopus， Web of Science和Embase，直到2024年9月，目标是随机对照试验（rct），评估HCR对MVCAD患者CABG的影响。采用ROB2工具评估纳入研究的质量，并使用RevMan 5.4对数据进行分析。采用随机效应模型对4项随机对照试验（n = 382） 382名受试者进行分析。使用ROB2工具评估偏倚风险。结果：4项rct （n = 382）符合纳入标准。30天时，HCR和CABG在全因死亡（风险比[RR] = 1.35, P = 0.74）、卒中（风险比[RR = 0.99, P = 0.99）、心肌梗死（风险比[RR = 1.17, P = 0.74）、输血（风险比[RR = 0.70, P = 0.14）方面无统计学差异，异质性为零（2 = 0%）。在1年的随访中，合并分析显示全因死亡（RR = 1.37, P = 0.62）或心肌梗死（RR = 1.29, P = 0.56）无显著差异，也具有一致的均匀性（I 2 = 0%）。结论：HCR对MVCAD的安全性和有效性与CABG相当，30天和1年的关键结局率相似。建议进行更大样本和更长时间随访的进一步研究，以证实这些发现。
{"title":"Long-term safety and effectiveness of hybrid coronary revascularization compared to conventional revascularization strategies: a systematic review and meta-analysis.","authors":"Singam Shashank, Rashmikaa Netyam, Chiranjeevee R Saravanan, Nikhil D Kolanu, Nanditha Karra, Harshada S Keluskar, Ziad Helaly, Mohammed H Albitar, Abdullah Sharbek, Seba Albitar, Pugazhendi Inban, Mohammed D M Marsool, Omniat A Hussin","doi":"10.1097/MS9.0000000000004561","DOIUrl":"10.1097/MS9.0000000000004561","url":null,"abstract":"<p><strong>Background: </strong>Hybrid coronary revascularization (HCR), a combination of percutaneous coronary intervention and coronary artery bypass grafting (CABG), is an emerging treatment for patients with multivessel coronary artery disease (MVCAD). While traditional CABG is considered the standard, HCR may mitigate issues like saphenous vein graft failure.</p><p><strong>Methods: </strong>We systematically searched PubMed, Scopus, Web of Science, and Embase until September 2024, targeting randomized controlled trials (RCTs) that evaluated HCR against CABG in MVCAD patients. The quality of included studies was assessed using the ROB2 tool, and data were analyzed using RevMan 5.4. Four RCTs (<i>n</i> = 382) involving 382 participants were analyzed using a random-effects model. Risk of bias was assessed using the ROB2 tool.</p><p><strong>Results: </strong>Four RCTs (<i>n</i> = 382) met inclusion criteria. At 30 days, there were no statistically significant differences between HCR and CABG in all-cause death (risk ratios [RR] = 1.35, <i>P</i> = 0.74), stroke (RR = 0.99, <i>P</i> = 0.99), myocardial infarction (RR = 1.17, <i>P</i> = 0.74), or blood transfusion (RR = 0.70, <i>P</i> = 0.14), with zero heterogeneity (<i>I</i> <sup>2</sup> = 0%). At 1-year follow-up, pooled analyses showed no significant differences in all-cause death (RR = 1.37, <i>P</i> = 0.62) or myocardial infarction (RR = 1.29, <i>P</i> = 0.56), also with consistent homogeneity (<i>I</i> <sup>2</sup> = 0%).</p><p><strong>Conclusion: </strong>HCR demonstrates comparable safety and effectiveness to CABG for MVCAD, with similar rates of key outcomes at both 30 days and 1 year. Further research with larger samples and longer follow-up is recommended to confirm these findings.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 2","pages":"1779-1788"},"PeriodicalIF":1.6,"publicationDate":"2026-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-09DOI: 10.1016/j.sleepx.2025.100171
Galit Levi Dunietz , Erica C. Jansen
{"title":"From awareness to action: Tackling sleep issues in college students","authors":"Galit Levi Dunietz , Erica C. Jansen","doi":"10.1016/j.sleepx.2025.100171","DOIUrl":"10.1016/j.sleepx.2025.100171","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-02DOI: 10.1016/j.sleepx.2025.100168
María Fernanda Gómez Morales , Nicole Cresp Sinning , Carlos H. Schenck
A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG). Case 1, a 30-year-old woman had a 20-yr history of non-injurious arm scratching/rubbing during sleep. vPSG: forearm rubbing against the chin during N2/N3. Two years later she developed restless bladder symptoms and leg movements before sleep onset. Serum ferritin level: 20.7 Intravenous iron therapy resulted in full control of bedtime leg movements, restless bladder symptoms, and nocturnal scratching. Case 2, a 28-year-old married man had a 1.5-yr history of perianal scratching with excoriations/bleeding during sleep, without other parasomnia. Medical and dermatologic evaluations were negative. vPSG: arousal index of 34/hr, with multiple episodes of perianal scratching. Paroxetine, 20 mg with clonazepam as (0.5–1.0 mg) at bedtime induced 50 % efficacy. Case 3, a 26-year-old African-American female had NREM parasomnias, vigorous sleep-related scratching with keloid formation, and major depression. Medical history was negative. vPSG: arousal index: 28/hr, without abnormal behaviors. Multiple sleep latency test (MSLT): mean sleep latency, 3.6 min, no REM sleep. Idiopathic hypersomnia and NREM parasomnias were diagnosed. Sleep-related scratching and NREM parasomnias responded fully to bedtime clonazepam, 0.5 mg. Case 4, a 50-year-old female had longstanding injurious sleep-related scratching, sleep terrors, and sleep bruxism. vPSG: 55 % sleep efficiency; arousal index: 25/hr, without abnormal behaviors or apneas. MSLT: no objective sleepiness. These cases of sleep-related scratching disorder represent a heterogeneous presumed variant of NREM arousal disorder with various comorbidities, and with full/partial control from diverse therapies.
{"title":"Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases","authors":"María Fernanda Gómez Morales , Nicole Cresp Sinning , Carlos H. Schenck","doi":"10.1016/j.sleepx.2025.100168","DOIUrl":"10.1016/j.sleepx.2025.100168","url":null,"abstract":"<div><div>A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG). Case 1, a 30-year-old woman had a 20-yr history of non-injurious arm scratching/rubbing during sleep. vPSG: forearm rubbing against the chin during N2/N3. Two years later she developed restless bladder symptoms and leg movements before sleep onset. Serum ferritin level: 20.7 Intravenous iron therapy resulted in full control of bedtime leg movements, restless bladder symptoms, and nocturnal scratching. Case 2, a 28-year-old married man had a 1.5-yr history of perianal scratching with excoriations/bleeding during sleep, without other parasomnia. Medical and dermatologic evaluations were negative. vPSG: arousal index of 34/hr, with multiple episodes of perianal scratching. Paroxetine, 20 mg with clonazepam as (0.5–1.0 mg) at bedtime induced 50 % efficacy. Case 3, a 26-year-old African-American female had NREM parasomnias, vigorous sleep-related scratching with keloid formation, and major depression. Medical history was negative. vPSG: arousal index: 28/hr, without abnormal behaviors. Multiple sleep latency test (MSLT): mean sleep latency, 3.6 min, no REM sleep. Idiopathic hypersomnia and NREM parasomnias were diagnosed. Sleep-related scratching and NREM parasomnias responded fully to bedtime clonazepam, 0.5 mg. Case 4, a 50-year-old female had longstanding injurious sleep-related scratching, sleep terrors, and sleep bruxism. vPSG: 55 % sleep efficiency; arousal index: 25/hr, without abnormal behaviors or apneas. MSLT: no objective sleepiness. These cases of sleep-related scratching disorder represent a heterogeneous presumed variant of NREM arousal disorder with various comorbidities, and with full/partial control from diverse therapies.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-02-04DOI: 10.1016/j.sleepx.2026.100175
Xi Luo , Zhonghua Yin , Xueli Sun , Ke Li
Objectives
This cross-sectional study, based on the two-process model of sleep regulation, explored the nonlinear relationships and interactions among nocturnal sleep duration, daytime napping, sleep quality, and mild cognitive impairment (MCI) in middle-aged and older Chinese adults.
Methods
Data from 7480 participants in the 2018 wave of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Restricted cubic splines modeled dose-response relationships, and stratified logistic regression assessed subgroup variations. Models were adjusted for sociodemographic, lifestyle, and clinical covariates.
Results
The lowest odds of MCI were observed among participants reporting 6–8 h of nocturnal sleep and 30–60 min of daytime napping. Short (<6 h) and long (>8 h) sleep durations, along with prolonged napping (≥90 min), were linked to higher odds of MCI. Sleep quality modified these associations: poor sleep quality elevated the odds of MCI, especially among long sleepers (OR = 1.88 vs. 1.33 for good sleep quality). Among short sleepers (<6 h), 30–60 min naps were associated with lower odds of MCI (OR = 0.72).
Conclusions
These findings indicate that, in this cross-sectional sample, 7–8 h of nocturnal sleep combined with 30–60 min of daytime napping were associated with better cognitive status, whereas long sleep with poor sleep quality was associated with higher odds of impairment. These observational associations, considered within a circadian–homeostatic framework, are hypothesis-generating and warrant confirmation in future longitudinal and interventional studies.
目的基于睡眠调节双过程模型，探讨中国中老年人群夜间睡眠时间、日间小睡、睡眠质量与轻度认知障碍（MCI）之间的非线性关系和相互作用。方法对2018年中国健康与退休纵向研究（CHARLS） 7480名参与者的数据进行分析。限制三次样条模拟剂量-反应关系，分层逻辑回归评估亚组变化。根据社会人口统计学、生活方式和临床协变量对模型进行了调整。结果夜间睡眠6-8小时、白天午睡30-60分钟的参与者患轻度认知障碍的几率最低。短（6小时）和长（8小时）的睡眠时间，以及长时间的午睡（≥90分钟），与轻度认知障碍的高风险相关。睡眠质量改变了这些关联：睡眠质量差会增加轻度认知障碍的几率，尤其是在长睡眠者中（OR = 1.88 vs. 1.33）。在短睡眠者（6小时）中，30-60分钟的小睡与轻度认知障碍的几率较低相关（OR = 0.72）。这些发现表明，在这个横断面样本中，7-8小时的夜间睡眠加上30-60分钟的白天午睡与更好的认知状态相关，而长时间睡眠和睡眠质量差与更高的认知障碍风险相关。这些观察到的关联，在昼夜节律-体内平衡的框架内被考虑，是假设的产生，并在未来的纵向和干预性研究中得到证实。
{"title":"Sleep quality modifies the association between nocturnal sleep, daytime napping, and mild cognitive impairment: A population-based dose-response study","authors":"Xi Luo , Zhonghua Yin , Xueli Sun , Ke Li","doi":"10.1016/j.sleepx.2026.100175","DOIUrl":"10.1016/j.sleepx.2026.100175","url":null,"abstract":"<div><h3>Objectives</h3><div>This cross-sectional study, based on the two-process model of sleep regulation, explored the nonlinear relationships and interactions among nocturnal sleep duration, daytime napping, sleep quality, and mild cognitive impairment (MCI) in middle-aged and older Chinese adults.</div></div><div><h3>Methods</h3><div>Data from 7480 participants in the 2018 wave of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Restricted cubic splines modeled dose-response relationships, and stratified logistic regression assessed subgroup variations. Models were adjusted for sociodemographic, lifestyle, and clinical covariates.</div></div><div><h3>Results</h3><div>The lowest odds of MCI were observed among participants reporting 6–8 h of nocturnal sleep and 30–60 min of daytime napping. Short (<6 h) and long (>8 h) sleep durations, along with prolonged napping (≥90 min), were linked to higher odds of MCI. Sleep quality modified these associations: poor sleep quality elevated the odds of MCI, especially among long sleepers (OR = 1.88 vs. 1.33 for good sleep quality). Among short sleepers (<6 h), 30–60 min naps were associated with lower odds of MCI (OR = 0.72).</div></div><div><h3>Conclusions</h3><div>These findings indicate that, in this cross-sectional sample, 7–8 h of nocturnal sleep combined with 30–60 min of daytime napping were associated with better cognitive status, whereas long sleep with poor sleep quality was associated with higher odds of impairment. These observational associations, considered within a circadian–homeostatic framework, are hypothesis-generating and warrant confirmation in future longitudinal and interventional studies.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2025-12-03DOI: 10.1016/j.sleepx.2025.100166
Merrill S. Wise
{"title":"Promoting pediatric sleep health in low-resource settings: A specialist's perspective","authors":"Merrill S. Wise","doi":"10.1016/j.sleepx.2025.100166","DOIUrl":"10.1016/j.sleepx.2025.100166","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145749918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research aims to explore the interplay between stakeholders and the US accounting standard setter on the accounting treatment of crypto assets. We applied the beliefs-actions-outcomes (BAO) model to capture stakeholders’ expectations, expressed in their comment letters in response to the Financial Accounting Standards Board’s Exposure Draft (FASB’s ED) on Topic 350, and to assess their expectations’ reflection in the revised version of the standard. We analysed the relationship between stakeholders’ beliefs, proposed actions, and the final standard’s outcome using PLS-SEM (partial least squares structural equation modelling) in SmartPLS. Furthermore, we examine whether feedback from the accountancy profession, a significant stakeholder group in this process, acts as a moderator of the belief-action relationship. The results confirm that the beliefs significantly influence the proposed actions but have a minimal impact on the outcome, with a small number of suggestions for improvement being integrated. The involvement of the accountancy profession moderated the relationship between beliefs and actions, only for the scope and measurement categories, reflecting their specialised knowledge and technical expertise. Through empirical results, current research contributes to the debate on crypto asset regulation by examining stakeholders’ expectations and how their participation has influenced this regulatory field, emphasising the standard-setting body’s responsiveness to their input. The study offers theoretical and practical insights into the interplay between stakeholders’ beliefs, their proposed actions, and the development of crypto accounting regulation (the outcome).
本研究旨在探讨利益相关者与美国会计准则制定者在加密资产会计处理方面的相互作用。我们应用信念-行动-结果（BAO）模型来捕捉利益相关者对财务会计准则委员会关于主题350的征求意见稿（FASB ' s ED）的评论信中表达的期望，并评估他们的期望在准则修订版中的反映。我们在SmartPLS中使用PLS-SEM（偏最小二乘结构方程模型）分析了利益相关者的信念、建议的行动和最终标准结果之间的关系。此外，我们研究了来自会计专业的反馈，在这一过程中一个重要的利益相关者群体，是否作为信念-行动关系的调节因子。结果证实，信念对所提议的行动有显著影响，但对结果的影响很小，只有少量的改进建议被整合。会计专业的参与调节了信念与行为之间的关系，仅在范围和测量类别上，反映了他们的专业知识和技术专长。通过实证结果，目前的研究通过检查利益相关者的期望以及他们的参与如何影响这一监管领域，强调标准制定机构对他们的投入的响应，为加密资产监管的辩论做出了贡献。该研究为利益相关者的信念、他们的拟议行动和加密会计监管的发展（结果）之间的相互作用提供了理论和实践见解。
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Pub Date : 2026-12-01Epub Date: 2025-12-29DOI: 10.1016/j.sleepx.2025.100172
Reut Gruber , Winfried Randerath
{"title":"Sleep without borders starts here: Principles and pathways for sleep health promotion","authors":"Reut Gruber , Winfried Randerath","doi":"10.1016/j.sleepx.2025.100172","DOIUrl":"10.1016/j.sleepx.2025.100172","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-12-01Epub Date: 2026-01-17DOI: 10.1016/j.sleepx.2026.100174
Emmanuel Eroumé A Egom , Bernadette Sandrine Lema , Elijah-Bill Christopher Nguem Nguem
Objective
To evaluate self-reported autonomic-like symptoms following sexual dreams in the SLEEP Study and characterize their perceived physiological patterns.
Methods
In a cross-sectional online study, 301 female-identifying adults reported physical and emotional sensations experienced immediately after sexual dreams. We summarized symptom prevalence using descriptive statistics.
Results
Increased heart rate (57.4 %) and sweating (35.0 %) were most frequently reported, followed by anxiety (33.9 %) and muscle tension (23.0 %). A minority (20.8 %) reported no symptoms, indicating variability in perceived arousal or recall. Symptom patterns reflected common co-occurrence of self-reported cardiovascular-like and affective experiences.
Discussion
These findings suggest that sexual dreams are often accompanied by self-reported autonomic-like experiences, although these reports do not represent objective physiological measurements. This brief report isolates the symptom dimension of the SLEEP Study dataset—a component not analyzed in our prior Sleep Research publication—and highlights the potential value of self-reported responses for studying REM-linked emotional arousal.
{"title":"Physiology of the subconscious: Autonomic activation during sexual dreaming","authors":"Emmanuel Eroumé A Egom , Bernadette Sandrine Lema , Elijah-Bill Christopher Nguem Nguem","doi":"10.1016/j.sleepx.2026.100174","DOIUrl":"10.1016/j.sleepx.2026.100174","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate self-reported autonomic-like symptoms following sexual dreams in the SLEEP Study and characterize their perceived physiological patterns.</div></div><div><h3>Methods</h3><div>In a cross-sectional online study, 301 female-identifying adults reported physical and emotional sensations experienced immediately after sexual dreams. We summarized symptom prevalence using descriptive statistics.</div></div><div><h3>Results</h3><div>Increased heart rate (57.4 %) and sweating (35.0 %) were most frequently reported, followed by anxiety (33.9 %) and muscle tension (23.0 %). A minority (20.8 %) reported no symptoms, indicating variability in perceived arousal or recall. Symptom patterns reflected common co-occurrence of self-reported cardiovascular-like and affective experiences.</div></div><div><h3>Discussion</h3><div>These findings suggest that sexual dreams are often accompanied by self-reported autonomic-like experiences, although these reports do not represent objective physiological measurements. This brief report isolates the symptom dimension of the SLEEP Study dataset—a component not analyzed in our prior <em>Sleep Research</em> publication—and highlights the potential value of self-reported responses for studying REM-linked emotional arousal.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study compared the efficacy and safety of integrative and conventional therapies for chronic insomnia.
Objective
To evaluate the effects of the Suk-Sai-Yat traditional Thai herbal remedy, Cannabis sativa oil (Deja formula) and lorazepam on sleep quality and quality of life in patients with chronic insomnia.
Methods
In a randomized controlled parallel-group trial, 60 adults with chronic insomnia received Suk-Sai-Yat, Cannabis sativa oil, or lorazepam for four weeks. Sleep quality was assessed using the Pittsburgh leep Quality Index (PSQI) and quality of life was evaluated using EQ-5D-5L and EQ-VAS. Safety was monitored throughout the study.
Results
After four weeks, PSQI scores significantly improved in all groups: Suk-Sai-Yat (12.3–6.6), Cannabis sativa oil (13.6–3.68) and lorazepam (14.4–5.8) (all p < 0.001), with no significant differences between groups. Quality-of-life scores improved significantly in the integrative therapy groups. Only mild adverse events were reported.
Conclusion
Suk-Sai-Yat and Cannabis sativa oil demonstrated comparable efficacy to lorazepam with favorable safety profiles, supporting their role as integrative, non-benzodiazepine options for chronic insomnia management.
{"title":"Integrative therapies for chronic insomnia: A randomized controlled trial of a traditional Thai Herbal Remedy and Cannabis sativa oil","authors":"Naruwat Pakdee, Nitcha Sribunrieng, Ronnachai Poowanna","doi":"10.1016/j.sleepx.2026.100173","DOIUrl":"10.1016/j.sleepx.2026.100173","url":null,"abstract":"<div><h3>Background</h3><div>This study compared the efficacy and safety of integrative and conventional therapies for chronic insomnia.</div></div><div><h3>Objective</h3><div>To evaluate the effects of the Suk-Sai-Yat traditional Thai herbal remedy, <em>Cannabis sativa</em> oil (Deja formula) and lorazepam on sleep quality and quality of life in patients with chronic insomnia.</div></div><div><h3>Methods</h3><div>In a randomized controlled parallel-group trial, 60 adults with chronic insomnia received Suk-Sai-Yat, <em>Cannabis sativa</em> oil, or lorazepam for four weeks. Sleep quality was assessed using the Pittsburgh leep Quality Index (PSQI) and quality of life was evaluated using EQ-5D-5L and EQ-VAS. Safety was monitored throughout the study.</div></div><div><h3>Results</h3><div>After four weeks, PSQI scores significantly improved in all groups: Suk-Sai-Yat (12.3–6.6), <em>Cannabis sativa</em> oil (13.6–3.68) and lorazepam (14.4–5.8) (all p < 0.001), with no significant differences between groups. Quality-of-life scores improved significantly in the integrative therapy groups. Only mild adverse events were reported.</div></div><div><h3>Conclusion</h3><div>Suk-Sai-Yat and <em>Cannabis sativa</em> oil demonstrated comparable efficacy to lorazepam with favorable safety profiles, supporting their role as integrative, non-benzodiazepine options for chronic insomnia management.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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