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Highly Enantioselective Polymerization of β-Butyrolactone by a Bimetallic Magnesium Catalyst: An Interdependent Relationship Between Favored and Unfavored Enantiomers. 双金属镁催化剂对 β-丁内酯的高对映选择性聚合:有利对映体和不利对映体之间的相互依赖关系。
IF 14.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-14 DOI: 10.1021/jacs.4c04716
Morgan S Young, Anne M LaPointe, Samantha N MacMillan, Geoffrey W Coates

Herein, we report that (S,S)-prophenolMg2(μ-OnBu)(THF)2 ((S,S)-1, prophenol = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-methylphenol) is a highly enantioselective (kR/kS = 140) precatalyst for ring-opening polymerization of rac-β-butyrolactone (β-BL) to isotactic poly(3-hydroxybutyrate) (i-PHB), a high performance, biodegradable polyester. Precatalyst (S,S)-1 polymerizes (R)-β-BL with an inversion of stereochemistry to (S)-PHB with a m% (percentage of adjacent linkages with a meso configuration) of 98% at 41% conversion and Tm of 165 °C under a variety of conditions. Complex (S,S)-1 demonstrates unique polymerization kinetics, as it does not polymerize the preferred enantiomer, (R)-β-BL, alone. Mechanistic studies revealed that (S)-β-BL is needed to convert (S,S)-1 into the active enantioselective polymerization catalyst. To the best of our knowledge, (S,S)-1 produces i-PHB with the highest degree of isotacticity observed from a polymerization of rac-β-BL. This study informs the design and understanding of future enantioselective and earth-abundant metal catalysts for ring-opening polymerization of β-lactones.

在此,我们报告了(S,S)-prophenolMg2(μ-OnBu)(THF)2((S,S)-1, prophenol = (S,S)-2、6-双[2-(羟基二苯甲基)吡咯烷-1-基甲基]-4-甲基苯酚)是一种高对映体选择性(kR/kS = 140)的前催化剂,可用于将 rac-β-butyrolactone (β-BL)开环聚合成高性能生物可降解聚酯异actic poly(3-hydroxybutyrate) (i-PHB)。在各种条件下,前催化剂 (S,S)-1 可将立体化学反转的 (R)-β-BL 聚合成 (S)-PHB,m%(具有中位构型的相邻链节百分比)为 98%,转化率为 41%,Tm 为 165 °C。复合物 (S,S)-1 显示出独特的聚合动力学,因为它不会单独聚合首选对映体 (R)-β-BL。机理研究表明,(S)-β-BL 是将 (S,S)-1 转化为活性对映体选择性聚合催化剂所必需的。据我们所知,(S,S)-1 生成的 i-PHB 具有从 rac-β-BL 的聚合反应中观察到的最高程度的异构性。这项研究有助于设计和理解未来用于 β-内酯开环聚合的对映体选择性和富土金属催化剂。
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引用次数: 0
Brain Glucose Metabolism as a Readout of the Central Nervous System Impact of Cigarette Smoke Exposure and Withdrawal and the Effects of NFL-101, as an Immune-Based Drug Candidate for Smoking Cessation Therapy. 作为中枢神经系统受卷烟烟雾暴露和戒烟影响的读数的脑葡萄糖代谢以及作为戒烟疗法免疫药物候选者的 NFL-101 的作用。
IF 4.1 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-07-03 Epub Date: 2024-06-14 DOI: 10.1021/acschemneuro.4c00204
Sébastien Goutal, Thi Tran, Claire Leroy, Nadine Benhamouda, Sarah Leterrier, Wadad Saba, Bruno Lafont, Éric Tartour, Marie Roelens, Nicolas Tournier

Neuroimaging biomarkers are needed to investigate the impact of smoking withdrawal on brain function. NFL-101 is a denicotinized aqueous extract of tobacco leaves currently investigated as an immune-based smoking cessation therapy in humans. However, the immune response to NFL-101 and its ability to induce significant changes in brain function remain to be demonstrated. Brain glucose metabolism was investigated using [18F]fluoro-deoxy-glucose ([18F]FDG) PET imaging in a mouse model of cigarette smoke exposure (CSE, 4-week whole-body inhalation, twice daily). Compared with control animals, the relative uptake of [18F]FDG in CSE mice was decreased in the thalamus and brain stem (p < 0.001, n = 14 per group) and increased in the hippocampus, cortex, cerebellum, and olfactory bulb (p < 0.001). NFL-101 induced a humoral immune response (specific IgGs) in mice and activated human natural-killer lymphocytes in vitro. In CSE mice, but not in control mice, single-dose NFL-101 significantly increased [18F]FDG uptake in the thalamus (p < 0.01), thus restoring normal brain glucose metabolism after 2-day withdrawal in this nicotinic receptor-rich region. In tobacco research, [18F]FDG PET imaging provides a quantitative method to evaluate changes in the brain function associated with the withdrawal phase. This method also showed the CNS effects of NFL-101, with translational perspectives for future clinical evaluation in smokers.

研究戒烟对大脑功能的影响需要神经影像生物标志物。NFL-101 是一种变性烟叶水提取物,目前正作为一种基于免疫的戒烟疗法对人体进行研究。然而,NFL-101 的免疫反应及其诱导脑功能显著变化的能力仍有待证实。我们使用[18F]氟脱氧葡萄糖([18F]FDG)正电子发射计算机断层成像技术对香烟烟雾暴露(CSE,4 周全身吸入,每天两次)小鼠模型的脑葡萄糖代谢进行了研究。与对照组相比,CSE小鼠丘脑和脑干对[18F]FDG的相对摄取减少(p < 0.001,每组14只),而海马、皮层、小脑和嗅球对[18F]FDG的相对摄取增加(p < 0.001)。NFL-101 可诱导小鼠产生体液免疫反应(特异性 IgGs),并在体外激活人类自然杀伤淋巴细胞。在 CSE 小鼠而非对照组小鼠中,单剂量 NFL-101 可显著增加丘脑中的 [18F]FDG 摄取(p < 0.01),从而使这一尼古丁受体丰富的区域在停药 2 天后恢复正常的脑糖代谢。在烟草研究中,[18F]FDG PET 成像为评估与戒烟阶段相关的脑功能变化提供了一种定量方法。这种方法还显示了 NFL-101 对中枢神经系统的影响,为今后对吸烟者进行临床评估提供了转化前景。
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引用次数: 0
Trimethylamine N-Oxide in Aquatic Foods. 水产食品中的三甲胺 N-氧化物。
IF 5.7 1区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-17 DOI: 10.1021/acs.jafc.4c01974
Xiaoyue Li, Chengcheng Wang, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang

Trimethylamine N-oxide (TMAO), a characteristic nonprotein nitrogen compound, is widely present in seafood, which exhibits osmoregulatory effects for marine organisms in vivo and plays an important role in aquaculture and aquatic product preservation. However, much attention has been focused on the negative effect of TMAO since it has recently emerged as a putative promoter of chronic diseases. To get full knowledge and maximize our ability to balance the positive and negative aspects of TMAO, in this review, we comprehensively discuss the TMAO in aquatic products from the aspects of physiological functions for marine organisms, flavor, quality, the conversion of precursors, the influences on human health, and the seafood ingredients interaction consideration. Though the circulating TMAO level is inevitably enhanced after seafood consumption, dietary seafood still exhibits beneficial health effects and may provide nutraceuticals to balance the possible adverse effects of TMAO.

三甲胺 N-氧化物(TMAO)是一种特征性非蛋白氮化合物,广泛存在于海产品中,在体内对海洋生物具有渗透调节作用,在水产养殖和水产品保鲜中发挥着重要作用。然而,由于 TMAO 近来被认为是慢性疾病的潜在诱发因素,其负面影响一直备受关注。为了充分了解并最大限度地平衡 TMAO 的正反两方面影响,本综述从对海洋生物的生理功能、风味、品质、前体转化、对人体健康的影响以及海产品成分相互作用等方面全面探讨了水产品中的 TMAO。虽然食用海产品后,循环中的 TMAO 水平不可避免地会升高,但膳食海产品仍具有有益健康的作用,并可提供营养保健品来平衡 TMAO 可能带来的不利影响。
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引用次数: 0
Exciton-Phonon Coupling Induces a New Pathway for Ultrafast Intralayer-to-Interlayer Exciton Transition and Interlayer Charge Transfer in WS2-MoS2 Heterostructure: A First-Principles Study. 在 WS2-MoS2 异质结构中,激子-暾欲子耦合诱导了层内到层内激子超快转变和层间电荷转移的新途径:第一原理研究。
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-18 DOI: 10.1021/acs.nanolett.4c01508
Yang-Hao Chan, Mit H Naik, Jonah B Haber, Jeffrey B Neaton, Steven G Louie, Diana Y Qiu, Felipe H da Jornada

Despite the weak, van der Waals interlayer coupling, photoinduced charge transfer vertically across atomically thin interfaces can occur within surprisingly fast, sub-50 fs time scales. An early theoretical understanding of charge transfer is based on a noninteracting picture, neglecting excitonic effects that dominate optical properties of such materials. We employ an ab initio many-body perturbation theory approach, which explicitly accounts for the excitons and phonons in the heterostructure. Our large-scale first-principles calculations directly probe the role of exciton-phonon coupling in the charge dynamics of the WS2/MoS2 heterobilayer. We find that the exciton-phonon interaction induced relaxation time of photoexcited excitons at the K valley of MoS2 and WS2 is 67 and 15 fs at 300 K, respectively, which sets a lower bound to the intralayer-to-interlayer exciton transfer time and is consistent with experiment reports. We further show that electron-hole correlations facilitate novel transfer pathways that are otherwise inaccessible to noninteracting electrons and holes.

尽管范德瓦耳斯层间耦合很弱,但光诱导电荷垂直穿过原子薄界面的传输速度却快得惊人,可达 50 fs 以下。对电荷转移的早期理论理解是基于非相互作用的图景,忽略了主导此类材料光学特性的激子效应。我们采用了一种 ab initio 多体扰动理论方法,该方法明确考虑了异质结构中的激子和声子。我们的大规模第一性原理计算直接探究了激子-声子耦合在 WS2/MoS2 异质层电荷动力学中的作用。我们发现,在 300 K 时,MoS2 和 WS2 K 谷光激发激子的弛豫时间分别为 67 fs 和 15 fs,这为层内到层间的激子转移时间设定了下限,并与实验报告一致。我们进一步证明,电子-空穴关联促进了新的转移途径,否则非相互作用的电子和空穴是无法进入这些途径的。
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引用次数: 0
Logic Gates Based on 3D Vertical Junctionless Gate-All-Around Transistors with Reliable Multilevel Contact Engineering. 基于三维垂直无结环栅晶体管的逻辑门与可靠的多级触点工程。
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-17 DOI: 10.1021/acs.nanolett.3c04180
Abhishek Kumar, Jonas Müller, Sylvain Pelloquin, Aurélie Lecestre, Guilhem Larrieu

Vertical gate-all-around (V-GAA) represents the ultimate configuration in the forthcoming transistor industry, but it still encounters challenges in the semiconductor community. This paper introduces, for the first time, a dual-input logic gate circuit achieved using 3D vertical transistors with nanoscale sub-20-nm GAA, employing a novel technique for creating contacts and patterning metallic lines at the bottom level without the conventional lift-off process. This involves a two-step oxidation process: patterning the first field oxide to form bottom metal lines and then creating the gate oxide layer on nanowires (NWs), followed by selective removal from the top and bottom of the nanostructures. VGAA-NW transistors, fabricated using the lift-off-free approach, exhibit improved yield and reduced access resistance, leading to an enhanced drive current while maintaining good immunity against short-channel effects. Finally, elementary two-input logic gates within a single cell, using VNW transistors, demonstrate novel possibilities in advanced logic circuitry design and routing options in 3D.

垂直全方位栅极(V-GAA)代表了未来晶体管行业的终极配置,但它在半导体界仍面临挑战。本文首次介绍了利用三维垂直晶体管和纳米级 20 纳米以下 GAA 实现的双输入逻辑栅极电路,采用了一种新技术在底层创建触点和图案化金属线,而无需传统的掀离工艺。这涉及一个两步氧化工艺:将第一层场氧化物图案化以形成底部金属线,然后在纳米线 (NW) 上创建栅极氧化层,接着选择性地从纳米结构的顶部和底部去除。采用无掀离方法制造的 VGAA-NW 晶体管提高了成品率,降低了接入电阻,从而提高了驱动电流,同时保持了对短沟道效应的良好抗扰性。最后,利用 VNW 晶体管在单个单元内制造出基本的双输入逻辑门,展示了三维高级逻辑电路设计和路由选择的新可能性。
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引用次数: 0
A "Ferroptosis-Amplifier" Hydrogel for Eliminating Refractory Cancer Stem Cells Post-lumpectomy. 一种用于消除肿瘤切除术后难治性癌症干细胞的 "铁突变-增殖 "水凝胶
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-17 DOI: 10.1021/acs.nanolett.4c02192
Yutong Zhu, Xi Deng, Zideng Dai, Qing Liu, Yichen Kuang, Tianzhi Liu, Hangrong Chen

The unique "Iron Addiction" feature of cancer stem cells (CSCs) with tumorigenicity and plasticity generally contributes to the tumor recurrence and metastasis after a lumpectomy. Herein, a novel "Ferroptosis Amplification" strategy is developed based on integrating gallic acid-modified FeOOH (GFP) and gallocyanine into Pluronic F-127 (F127) and carboxylated chitosan (CC)-based hydrogel for CSCs eradication. This "Ferroptosis Amplifier" hydrogel is thermally sensitive and achieves rapid gelation at the postsurgical wound in a breast tumor model. Specifically, gallocyanine, as the Dickkopf-1 (DKK1) inhibitor, can decrease the expression of SLC7A11 and GPX4 and synergistically induce ferroptosis of CSCs with GFP. Encouragingly, it is found that this combination suppresses the migratory and invasive capability of cancer cells via the downregulation of matrix metalloproteinase 7 (MMP7). The in vivo results further confirm that this "Ferroptosis Amplification" strategy is efficient in preventing tumor relapse and lung metastasis, manifesting an effective and promising postsurgical treatment for breast cancer.

癌症干细胞(CSCs)具有独特的 "铁瘾 "特征,具有致瘤性和可塑性,通常会导致肿瘤切除术后的复发和转移。本文基于将没食子酸修饰的FeOOH(GFP)和没食子色素整合到基于Pluronic F-127(F127)和羧基壳聚糖(CC)的水凝胶中,开发出一种新型的 "铁嗜性放大 "策略,用于消灭癌干细胞。这种 "铁突变放大器 "水凝胶对热敏感,可在乳腺肿瘤模型的手术后伤口处快速凝胶化。具体来说,五倍子菁作为Dickkopf-1(DKK1)抑制剂,可以降低SLC7A11和GPX4的表达,并协同诱导带有GFP的CSCs铁突变。令人鼓舞的是,研究还发现这种组合能通过下调基质金属蛋白酶 7(MMP7)抑制癌细胞的迁移和侵袭能力。体内研究结果进一步证实,这种 "铁突变放大 "策略能有效防止肿瘤复发和肺转移,是一种有效且有前景的乳腺癌术后治疗方法。
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引用次数: 0
Dynamic Regulation of Cell Mechanotransduction through Sequentially Controlled Mobile Surfaces. 通过顺序控制的移动表面动态调节细胞的机械传导。
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-18 DOI: 10.1021/acs.nanolett.4c01371
Wenyan Xie, Linjie Ma, Peng Wang, Xiaojing Liu, Di Wu, Yuan Lin, Zhiqin Chu, Yong Hou, Qiang Wei

The physical properties of nanoscale cell-extracellular matrix (ECM) ligands profoundly impact biological processes, such as adhesion, motility, and differentiation. While the mechanoresponse of cells to static ligands is well-studied, the effect of dynamic ligand presentation with "adaptive" properties on cell mechanotransduction remains less understood. Utilizing a controllable diffusible ligand interface, we demonstrated that cells on surfaces with rapid ligand mobility could recruit ligands through activating integrin α5β1, leading to faster focal adhesion growth and spreading at the early adhesion stage. By leveraging UV-light-sensitive anchor molecules to trigger a "dynamic to static" transformation of ligands, we sequentially activated α5β1 and αvβ3 integrins, significantly promoting osteogenic differentiation of mesenchymal stem cells. This study illustrates how manipulating molecular dynamics can directly influence stem cell fate, suggesting the potential of "sequentially" controlled mobile surfaces as adaptable platforms for engineering smart biomaterial coatings.

纳米级细胞-细胞外基质(ECM)配体的物理特性对粘附、运动和分化等生物过程有着深远的影响。虽然细胞对静态配体的机械响应研究得很透彻,但具有 "自适应 "特性的动态配体呈现对细胞机械传导的影响仍不甚了解。利用可控扩散配体界面,我们证明了配体快速移动表面上的细胞可以通过激活整合素α5β1来招募配体,从而在早期粘附阶段加快病灶粘附的生长和扩散。通过利用对紫外线敏感的锚分子触发配体的 "动静 "转换,我们依次激活了α5β1和αvβ3整合素,显著促进了间充质干细胞的成骨分化。这项研究说明了操纵分子动力学如何直接影响干细胞的命运,表明了 "顺序 "控制移动表面作为工程智能生物材料涂层的适应性平台的潜力。
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引用次数: 0
A Biphasic Strategy to Synergistically Accelerate Activation and CO Spillover in Formic Acid Oxidation Catalysis. 在甲酸氧化催化过程中协同加速活化和一氧化碳溢出的双相策略。
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-20 DOI: 10.1021/acs.nanolett.4c02074
Changhong Zhan, Haoran Sun, Wei Yan, Jing Xia, Xiang-Min Meng, Tongtong Li, Lingzheng Bu, Qingyu Kong, Haixin Lin, Wei Liu, Xiaoqing Huang, Nanjun Chen

Developing highly efficient and carbon monoxide (CO)-tolerant platinum (Pt) catalysts for the formic acid oxidation reaction (FAOR) is vital for direct formic acid fuel cells (DFAFCs), yet it is challenging due to the high energy barrier of direct intermediates (HCOO* and COOH*) as well as the CO poisoning issues associated with Pt alloy catalysts. Here we present a versatile biphasic strategy by creating a hexagonal/cubic crystalline-phase-synergistic PtPb/C (h/c-PtPb/C) catalyst to tackle the aforementioned issues. Detailed investigations reveal that h/c-PtPb/C can simultaneously facilitate the adsorption of direct intermediates while inhibiting CO adsorption, thereby significantly improving the activation and CO spillover. As a result, h/c-PtPb/C showcases an outstanding FAOR activity of 8.1 A mgPt-1, which is 64.5 times higher than that of commercial Pt/C and significantly surpasses monophasic PtPb. Moreover, the h/c-PtPb/C-based membrane electrode assembly exhibits an exceptional peak power density of 258.7 mW cm-2 for practical DFAFC applications.

为甲酸氧化反应(FAOR)开发高效且耐一氧化碳(CO)的铂(Pt)催化剂对直接甲酸燃料电池(DFAFC)至关重要,但由于直接中间产物(HCOO* 和 COOH*)的高能垒以及与铂合金催化剂相关的 CO 中毒问题,开发这种催化剂具有挑战性。在此,我们通过创建六方/立方晶相协同 PtPb/C(h/c-PtPb/C)催化剂,提出了一种多功能双相策略,以解决上述问题。详细研究表明,h/c-PtPb/C 可在抑制 CO 吸附的同时促进直接中间产物的吸附,从而显著改善活化和 CO 溢出。因此,h/c-PtPb/C 的 FAOR 活性高达 8.1 A mgPt-1,是商用 Pt/C 的 64.5 倍,大大超过了单相 PtPb。此外,基于 h/c-PtPb/C 的膜电极组件的峰值功率密度高达 258.7 mW cm-2,非常适合实际的 DFAFC 应用。
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引用次数: 0
Adaptive Signal Modulation Evolved by the Inherent Nonlinearity of Phase-Change Quantum-Dot String. 由相变量子点弦固有非线性演变而来的自适应信号调制。
IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-20 DOI: 10.1021/acs.nanolett.4c01786
Qin Wan, Fei Zeng, Ziao Lu, Junwei Yu, Tongjin Chen, Feng Pan

To simulate a topological neural network handling weak signals via stochastic resonance (SR), it is necessary to introduce an inherent nonlinearity into nanoscale devices. We use the self-assembly method to successfully fabricate a phase-change quantum-dot string (PCQDS) crossing Pd/Nb:AlNO/AlNO/Nb:AlNO/Pd multilayer. The inherent nonlinearity of phase change couples with electron tunneling so that PCQDS responds to a long signal sequence in a modulated output style, in which the pulse pattern evolves to that enveloped by two sets of periodic wave characterized by neural action potential. We establish an SR mode consisting of several two-state systems in which dissipative tunneling is coupled to environment. Size oscillations owing to NbO QDs adaptively adjust barriers and wells, such that tunneling can be periodically modulated by either asymmetric energy or local temperature. When the external periodic signals are applied, the system first follows the forcing frequency. Subsequently, certain PCQDs oscillate independently and consecutively to produce complicated frequency and amplitude modulations.

要通过随机共振(SR)模拟处理微弱信号的拓扑神经网络,就必须在纳米级器件中引入固有的非线性。我们利用自组装方法成功地制造出了跨越 Pd/Nb:AlNO/AlNO/Nb:AlNO/Pd 多层的相变量子点串(PCQDS)。相变的固有非线性与电子隧道耦合,使 PCQDS 能够以调制输出方式响应长信号序列,其中脉冲模式演变为由两组周期性波包围的神经动作电位模式。我们建立了一种由多个双态系统组成的 SR 模式,其中耗散隧道与环境耦合。NbO QD 的尺寸振荡会自适应地调整壁垒和阱,从而使隧穿受到非对称能量或局部温度的周期性调制。当施加外部周期性信号时,系统首先跟随强迫频率。随后,某些 PCQD 独立并连续振荡,产生复杂的频率和振幅调制。
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引用次数: 0
Facile Mechanophore Integration in Heterogeneous Biologically Derived Materials via "Dip-Conjugation". 通过 "Dip-Conjugation",在异质生物衍生材料中实现便捷的机械融合。
IF 14.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-03 Epub Date: 2024-06-20 DOI: 10.1021/jacs.4c03534
Yifan Liao, Baptiste Le Roi, Hang Zhang, Charles E Diesendruck, Joshua M Grolman

Mechanical forces play critical roles in a wide variety of biological processes and diseases, yet measuring them directly at the molecular level remains one of the main challenges of mechanobiology. Here, we show a strategy to "Dip-conjugate" biologically derived materials at the chemical level to mechanophores, force-responsive molecular entities, using Click-chemistry. Contrary to classical prepolymerization mechanophore incorporation, this new protocol leads to detectable mechanochromic response with as low as 5% strain, finally making mechanophores relevant for many biological processes that have previously been inaccessible. Our results demonstrate the ubiquity of the technique with activation in synthetic polymers, carbohydrates, and proteins under mechanical force, with alpaca wool fibers as a key example. These results push the limits for mechanophore use in far more types of polymeric materials in applications ranging from molecular-level force damage detection to direct and quantitative 3D force measurements in mechanobiology.

机械力在各种生物过程和疾病中发挥着关键作用,但在分子水平直接测量机械力仍然是机械生物学的主要挑战之一。在这里,我们展示了一种利用点击化学(Click-chemistry)在化学水平上将生物衍生材料 "Dip-conjugate "到机械分子(力响应分子实体)的策略。与传统的预聚合机械分子掺入相反,这种新方法能在低至 5%应变的情况下产生可检测到的机械变色反应,最终使机械分子与许多以前无法实现的生物过程相关联。以羊驼毛纤维为例,我们的研究结果表明,在机械力的作用下,这项技术可以激活合成聚合物、碳水化合物和蛋白质。这些研究结果将机械分子团应用于更多类型的聚合物材料中,从分子水平的力损伤检测到机械生物学中直接和定量的三维力测量,这些研究结果将机械分子团的应用推向了极致。
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引用次数: 0
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