Pub Date : 2025-02-22DOI: 10.1016/j.optlastec.2025.112604
Naiwen Fang , Zhiqiang Feng , Pengbo Wu , Jiutian Luo , Ruisheng Huang , Kai Xu , Jipeng Zou , Hao Cao , Laibo Sun , Quan Li , Bintao Wu
A new type of flux-cored filler wire was designed by synchronously optimizing Mo and Fe elements, and it was applied to narrow gap laser oscillating wire filler welding (NG-LOWFW) of ultra-thick titanium alloy, the effects of process parameters on the stability of welding process, microstructure and mechanical properties of welded joint were studied by experiment and numerical simulation. The results show that the oscillating laser and the liquid bridge transition mode could increase heat exchange between molten pool surface and external environment, resulting in high undercooling conditions, reduced thermal gradient, and guarantee the stability of the welding process effectively, the microstructure evolution of ultra-thick welded seam is uniform, the grain size is refined and the welding defects are restrained effectively. Moreover, Mo and Fe elements could further enhance the wetting and spreading mobility of liquid metal during welding, which contributes to the synergistic optimization of strength and toughness of ultra-thick welded joint, up to 935 MPa and 25 J. The research outcomes provide a new route for welding ultra-thick titanium alloy, which benefits further welding process and optimization.
{"title":"Oscillating laser welding of ultra-thick titanium alloy using new flux-cored filler wire: Process stability, microstructural evolution and mechanical properties","authors":"Naiwen Fang , Zhiqiang Feng , Pengbo Wu , Jiutian Luo , Ruisheng Huang , Kai Xu , Jipeng Zou , Hao Cao , Laibo Sun , Quan Li , Bintao Wu","doi":"10.1016/j.optlastec.2025.112604","DOIUrl":"10.1016/j.optlastec.2025.112604","url":null,"abstract":"<div><div>A new type of flux-cored filler wire was designed by synchronously optimizing Mo and Fe elements, and it was applied to narrow gap laser oscillating wire filler welding (NG-LOWFW) of ultra-thick titanium alloy, the effects of process parameters on the stability of welding process, microstructure and mechanical properties of welded joint were studied by experiment and numerical simulation. The results show that the oscillating laser and the liquid bridge transition mode could increase heat exchange between molten pool surface and external environment, resulting in high undercooling conditions, reduced thermal gradient, and guarantee the stability of the welding process effectively, the microstructure evolution of ultra-thick welded seam is uniform, the grain size is refined and the welding defects are restrained effectively. Moreover, Mo and Fe elements could further enhance the wetting and spreading mobility of liquid metal during welding, which contributes to the synergistic optimization of strength and toughness of ultra-thick welded joint, up to 935 MPa and 25 J. The research outcomes provide a new route for welding ultra-thick titanium alloy, which benefits further welding process and optimization.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112604"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.optlastec.2025.112629
K. González-León , R.J. Delgado-Macuil , B. Vertti-Cervantes , S. Muñoz-Aguirre , J. Castillo-Mixcóatl , M. García-Juárez , O. Montes-Narvaez , E. Ramírez-Sánchez , G. Beltrán-Pérez
Currently, techniques such as machine learning (ML), derived from great technological progress, play a fundamental role in different areas, from finance, marketing, security, education, transportation to science and health. The latter, with the growth in the development of sensors and biosensors, technological tools such as ML allow systems to learn, extract, analyze and classify useful information from the signals they receive. Biosensors, being devices that convert biological signals into quantifiable data, generate a large volume of information, which becomes difficult to interpret manually, but can be processed more efficiently through ML. Support vector machine (SVM), is a supervised machine learning technique, used for classification, regression and even outliers detection, especially useful in the context of biosensors to classify them into different biological states forming a discriminant analysis. This work focuses on the study of SVM as a classifying technique, applied to optical fiber biosensors for the detection of Interleukin 10 (IL-10) due to its role as a neuroprotector protein. Serum samples from ischemic, and ischemic treated with estradiol benzoate (EB) male rats were evaluated at 2 h post-ischemia. In this work we show the performance of SVM on the measured responses of three optical fiber biosensor that are based on a tapered, long period grating and Mach-Zehnder interferometer. The results demonstrate that SVM technique is a good alternative to determine the IL-10 expression on serum sample of a murine model.
{"title":"Application of support vector machine technique to optical fiber biosensors for neuroprotector (IL-10) detection in serum samples of murine model","authors":"K. González-León , R.J. Delgado-Macuil , B. Vertti-Cervantes , S. Muñoz-Aguirre , J. Castillo-Mixcóatl , M. García-Juárez , O. Montes-Narvaez , E. Ramírez-Sánchez , G. Beltrán-Pérez","doi":"10.1016/j.optlastec.2025.112629","DOIUrl":"10.1016/j.optlastec.2025.112629","url":null,"abstract":"<div><div>Currently, techniques such as machine learning (ML), derived from great technological progress, play a fundamental role in different areas, from finance, marketing, security, education, transportation to science and health. The latter, with the growth in the development of sensors and biosensors, technological tools such as ML allow systems to learn, extract, analyze and classify useful information from the signals they receive. Biosensors, being devices that convert biological signals into quantifiable data, generate a large volume of information, which becomes difficult to interpret manually, but can be processed more efficiently through ML. Support vector machine (SVM), is a supervised machine learning technique, used for classification, regression and even outliers detection, especially useful in the context of biosensors to classify them into different biological states forming a discriminant analysis. This work focuses on the study of SVM as a classifying technique, applied to optical fiber biosensors for the detection of Interleukin 10 (IL-10) due to its role as a neuroprotector protein. Serum samples from ischemic, and ischemic treated with estradiol benzoate (EB) male rats were evaluated at 2 h post-ischemia. In this work we show the performance of SVM on the measured responses of three optical fiber biosensor that are based on a tapered, long period grating and Mach-Zehnder interferometer. The results demonstrate that SVM technique is a good alternative to determine the IL-10 expression on serum sample of a murine model.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112629"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.optlastec.2025.112649
Yilin Li , Man Zhang , Liangping Xia , Chunyan Wang , Zengbao Yang , Suihu Dang , Guohui Chen , Wenqing Zhu , Chunlei Du
The hourglass-type nanopillars were proposed to construct a metasurface that can achieve linear beam homogenization. Compared with general cylindrical structures, the optical response of this hourglass-shaped nanopillar is more stable at small scales and has a higher tolerance for processing errors. We designed a linear beam-homogenized metasurface with a 90 degrees divergence effect using hourglass-shaped nanopillars. According to the test results, at the operating wavelength of 632 nm, the metasurface has a spot uniformity of 68.34 % and a divergent angle of 91.79 degrees. As demonstrated by the results, the hourglass-type nanoapillar metasurface has excellent performance and significant development potential for line laser homogenization with a controllable divergent angle.
{"title":"Linear homogenization of laser with hourglass-shaped nanopillars metasurface","authors":"Yilin Li , Man Zhang , Liangping Xia , Chunyan Wang , Zengbao Yang , Suihu Dang , Guohui Chen , Wenqing Zhu , Chunlei Du","doi":"10.1016/j.optlastec.2025.112649","DOIUrl":"10.1016/j.optlastec.2025.112649","url":null,"abstract":"<div><div>The hourglass-type nanopillars were proposed to construct a metasurface that can achieve linear beam homogenization. Compared with general cylindrical structures, the optical response of this hourglass-shaped nanopillar is more stable at small scales and has a higher tolerance for processing errors. We designed a linear beam-homogenized metasurface with a 90 degrees divergence effect using hourglass-shaped nanopillars. According to the test results, at the operating wavelength of 632 nm, the metasurface has a spot uniformity of 68.34 % and a divergent angle of 91.79 degrees. As demonstrated by the results, the hourglass-type nanoapillar metasurface has excellent performance and significant development potential for line laser homogenization with a controllable divergent angle.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112649"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.optlastec.2025.112644
Xiankun Liu , Yuan Sui , Rui Li , Weida Chen , Penghui Dai , Taiji Dong , Yu Sun , Zhicheng Cong , Xu Liu , Chunlei Jiang
In recent years, sensing structures based on optical trapping technology have found widespread application in measuring weak forces, vibrations, and temperature variations due to their exceptional detection sensitivity and resolution. However, the requirements for high integration, microsphere self-assembly, and sealed environments pose challenges to the practical engineering application of optical tweezer sensing structures. This study presents a novel optical tweezer sensing structure utilizing a capillary tube. A tapered hollow capillary coupled with a tapered optical fiber forms a trapping chamber, where a 5 μm silica microsphere is captured at the fiber tip. Vibrations are detected by monitoring variations in the reflected light intensity of the microsphere. Experimental results demonstrate that the sensing structure exhibits a strong response to vibrations within the frequency range of 10 Hz to 20 kHz and amplitudes at or above the sub-micrometer level. The confined space of the capillary tube restricts the diffusion of microspheres, enabling automatic resetting under the influence of optical trapping forces. This design not only protects the optical tweezer structure but also enhances the integration of the sensing unit, maximizing the flexibility of fiber-optic tweezer sensors and advancing their practical application.
{"title":"Capillary-encapsulated single-fiber optical tweezer for vibration sensing","authors":"Xiankun Liu , Yuan Sui , Rui Li , Weida Chen , Penghui Dai , Taiji Dong , Yu Sun , Zhicheng Cong , Xu Liu , Chunlei Jiang","doi":"10.1016/j.optlastec.2025.112644","DOIUrl":"10.1016/j.optlastec.2025.112644","url":null,"abstract":"<div><div>In recent years, sensing structures based on optical trapping technology have found widespread application in measuring weak forces, vibrations, and temperature variations due to their exceptional detection sensitivity and resolution. However, the requirements for high integration, microsphere self-assembly, and sealed environments pose challenges to the practical engineering application of optical tweezer sensing structures. This study presents a novel optical tweezer sensing structure utilizing a capillary tube. A tapered hollow capillary coupled with a tapered optical fiber forms a trapping chamber, where a 5 μm silica microsphere is captured at the fiber tip. Vibrations are detected by monitoring variations in the reflected light intensity of the microsphere. Experimental results demonstrate that the sensing structure exhibits a strong response to vibrations within the frequency range of 10 Hz to 20 kHz and amplitudes at or above the sub-micrometer level. The confined space of the capillary tube restricts the diffusion of microspheres, enabling automatic resetting under the influence of optical trapping forces. This design not only protects the optical tweezer structure but also enhances the integration of the sensing unit, maximizing the flexibility of fiber-optic tweezer sensors and advancing their practical application.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112644"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is difficult for traditional underwater acoustic emission transducers to possess low-frequency, broadband and high-efficiency characteristics simultaneously. In this paper, we propose a novel kind of meta-structure underwater transducer with its cover composed of a circular plate, ribs and additional mass units, and reveal the mechanisms of local resonance efficient acoustic emission and synergistic coupling broadband acoustic emission. The genetic algorithm (GA) is adopted to optimize the parameters of the meta-structure cover, and the low-frequency broadband efficient underwater acoustic emission with the sound pressure level (SPL) fluctuation of 6 dB in 100–2500 Hz is realized. Subsequently, the radial magnetic circuit is used as the driving device, and the prototype of the meta-structure underwater acoustic transducer is developed. The experimental results confirm the acoustic emission performance of the prototype, which is expected to show significant potential in long-range underwater acoustic communication.
{"title":"Meta-structure underwater transducer with low-frequency broadband efficient acoustic emission","authors":"Yunzhong Lei, Jiu Hui Wu, Shaokun Yang, Tengyue Zheng","doi":"10.1016/j.apacoust.2025.110622","DOIUrl":"10.1016/j.apacoust.2025.110622","url":null,"abstract":"<div><div>It is difficult for traditional underwater acoustic emission transducers to possess low-frequency, broadband and high-efficiency characteristics simultaneously. In this paper, we propose a novel kind of <em>meta</em>-structure underwater transducer with its cover composed of a circular plate, ribs and additional mass units, and reveal the mechanisms of local resonance efficient acoustic emission and synergistic coupling broadband acoustic emission. The genetic algorithm (GA) is adopted to optimize the parameters of the <em>meta</em>-structure cover, and the low-frequency broadband efficient underwater acoustic emission with the sound pressure level (SPL) fluctuation of 6 dB in 100–2500 Hz is realized. Subsequently, the radial magnetic circuit is used as the driving device, and the prototype of the <em>meta</em>-structure underwater acoustic transducer is developed. The experimental results confirm the acoustic emission performance of the prototype, which is expected to show significant potential in long-range underwater acoustic communication.</div></div>","PeriodicalId":55506,"journal":{"name":"Applied Acoustics","volume":"233 ","pages":"Article 110622"},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present paper, a 200 W diode laser equipped with a beam expander was adopted to create hybrid joints between pure PEEK polymer and titanium alloy (Ti6Al4V). To this end, a new setup was developed: the laser was equipped with a 5x beam expander, allowing the laser beam a spot of about 30 mm, and the joints were performed in static conditions. The latter allows more efficient control of the joining process, identifying the technological window of processability of the polymer, thus avoiding ineffective heating or excessive degradation during laser-assisted joining operations. Moreover, the adopted setup is very cost-effective from an industrial perspective, depending on the low powers applied, compared with those adopted in the literature. Single-lap joints were carried out in order to study the influence of the laser parameters on the joint strength. Before joining, two different textures were performed on the titanium surface; mechanical tests were carried out to determine the optimal processing conditions, while fracture surface analysis and morphological one were performed in order to better understand the phenomena developing during the joining process. The design of experiments (DoE) approach and analysis of variance (ANOVA) were adopted to identify significant process control factors and analyze how they influence joint performance. From the results, the new setup allows a joint efficiency of about 30 % in the best conditions, a very high value, compared to other traditional joining processes, such as adhesive bonding.
{"title":"Study on laser-assisted joining of titanium (Ti6Al4V) to polyether ether ketone (PEEK) for Enhanced hybrid joints","authors":"Silvio Genna , Patrizia Moretti , Gennaro Salvatore Ponticelli , Simone Venettacci","doi":"10.1016/j.optlastec.2025.112681","DOIUrl":"10.1016/j.optlastec.2025.112681","url":null,"abstract":"<div><div>In the present paper, a 200 W diode laser equipped with a beam expander was adopted to create hybrid joints between pure PEEK polymer and titanium alloy (Ti6Al4V). To this end, a new setup was developed: the laser was equipped with a 5x beam expander, allowing the laser beam a spot of about 30 mm, and the joints were performed in static conditions. The latter allows more efficient control of the joining process, identifying the technological window of processability of the polymer, thus avoiding ineffective heating or excessive degradation during laser-assisted joining operations. Moreover, the adopted setup is very cost-effective from an industrial perspective, depending on the low powers applied, compared with those adopted in the literature. Single-lap joints were carried out in order to study the influence of the laser parameters on the joint strength. Before joining, two different textures were performed on the titanium surface; mechanical tests were carried out to determine the optimal processing conditions, while fracture surface analysis and morphological one were performed in order to better understand the phenomena developing during the joining process. The design of experiments (DoE) approach and analysis of variance (ANOVA) were adopted to identify significant process control factors and analyze how they influence joint performance. From the results, the new setup allows a joint efficiency of about 30 % in the best conditions, a very high value, compared to other traditional joining processes, such as adhesive bonding.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112681"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-22DOI: 10.1016/j.apacoust.2025.110620
Yuxing Li , Yang Liu , Xiang Gao
Lempel-Ziv complexity (LZC) has important significance in nonlinear science as a measure of time series complexity. The previously proposed dispersion entropy-based Lempel-Ziv complexity (DELZC) effectively improves the performance of traditional LZC, but it still has problems such as information loss and inaccurate complexity characterization. To overcome these limitations, fuzzy dispersion entropy-based Lempel-Ziv complexity (FDELZC) is proposed, which utilizes fuzzy function to obtain accurate pattern partitioning and the accurate pattern information makes the symbol information more accurate, the result is a more accurate complexity characterization for signals. Furthermore, FDELZC is extended to multiscale fuzzy dispersion entropy-based Lempel-Ziv complexity (MFDELZC), which characterizes the sequence complexity information from different scales. Three sets of simulation signal experiments show that FDELZC can effectively captures dynamic time series changes, and has good anti-interference and differentiation ability. Two sets of real-world signal experiments demonstrate the significant advantage of FDELZC over LZC, PLZC, DLZC, and DELZC in distinguishing real-world hydroacoustic signals.
{"title":"Fuzzy dispersion entropy-based Lempel-Ziv complexity and its multiscale version for measuring the complexity of time series","authors":"Yuxing Li , Yang Liu , Xiang Gao","doi":"10.1016/j.apacoust.2025.110620","DOIUrl":"10.1016/j.apacoust.2025.110620","url":null,"abstract":"<div><div>Lempel-Ziv complexity (LZC) has important significance in nonlinear science as a measure of time series complexity. The previously proposed dispersion entropy-based Lempel-Ziv complexity (DELZC) effectively improves the performance of traditional LZC, but it still has problems such as information loss and inaccurate complexity characterization. To overcome these limitations, fuzzy dispersion entropy-based Lempel-Ziv complexity (FDELZC) is proposed, which utilizes fuzzy function to obtain accurate pattern partitioning and the accurate pattern information makes the symbol information more accurate, the result is a more accurate complexity characterization for signals. Furthermore, FDELZC is extended to multiscale fuzzy dispersion entropy-based Lempel-Ziv complexity (MFDELZC), which characterizes the sequence complexity information from different scales. Three sets of simulation signal experiments show that FDELZC can effectively captures dynamic time series changes, and has good anti-interference and differentiation ability. Two sets of real-world signal experiments demonstrate the significant advantage of FDELZC over LZC, PLZC, DLZC, and DELZC in distinguishing real-world hydroacoustic signals.</div></div>","PeriodicalId":55506,"journal":{"name":"Applied Acoustics","volume":"233 ","pages":"Article 110620"},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renal tumor biopsy is essential for diagnosing and treating renal cell carcinomas (RCC). However, due to sampling errors or missing the lesion during biopsy, multiple biopsies are often necessary to ensure accuracy. In this study, we investigated the potential of a miniaturized dual-modality spectroscopic probe, which integrates diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS), for distinguishing renal tumors from normal tissue in situ. This probe has a slender outer diameter of 1.0 mm, allowing it to fit comfortably within a biopsy needle and reach renal tissue. DRS and FS data were collected from 237 locations in 30 fresh renal specimens, including both normal and RCC tissues, obtained from 30 renal surgery patients. The results were then compared with co-registered clinical standard histopathology. Notably, the median reflectance intensity in clear-cell RCC (ccRCC) tissues was significantly higher compared to normal renal tissues. Both Adaboost and VGG-19 classifiers were then employed to distinguish ccRCC from normal tissue. Our method could achieve over 93 % sensitivity and specificity with the Adaboost classifier on dual-modality spectrum data. Our results indicate that dual-modality spectroscopy holds promising potential as a label-free, real-time, in vivo renal tumor guidance tool during biopsy or radiofrequency ablation procedures, ultimately improving treatment outcomes.
{"title":"In situ detection of renal cell carcinomas using diffuse reflectance and fluorescence spectroscopy for enhanced biopsy guidance: An ex vivo study","authors":"Kerui Li , Zhuo Jia , Changhao Ren , Chengli Xu , Xiangjun Lyu , Defu Chen","doi":"10.1016/j.optlastec.2025.112631","DOIUrl":"10.1016/j.optlastec.2025.112631","url":null,"abstract":"<div><div>Renal tumor biopsy is essential for diagnosing and treating renal cell carcinomas (RCC). However, due to sampling errors or missing the lesion during biopsy, multiple biopsies are often necessary to ensure accuracy. In this study, we investigated the potential of a miniaturized dual-modality spectroscopic probe, which integrates diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS), for distinguishing renal tumors from normal tissue <em>in situ</em>. This probe has a slender outer diameter of 1.0 mm, allowing it to fit comfortably within a biopsy needle and reach renal tissue. DRS and FS data were collected from 237 locations in 30 fresh renal specimens, including both normal and RCC tissues, obtained from 30 renal surgery patients. The results were then compared with co-registered clinical standard histopathology. Notably, the median reflectance intensity in clear-cell RCC (ccRCC) tissues was significantly higher compared to normal renal tissues. Both Adaboost and VGG-19 classifiers were then employed to distinguish ccRCC from normal tissue. Our method could achieve over 93 % sensitivity and specificity with the Adaboost classifier on dual-modality spectrum data. Our results indicate that dual-modality spectroscopy holds promising potential as a label-free, real-time, <em>in vivo</em> renal tumor guidance tool during biopsy or radiofrequency ablation procedures, ultimately improving treatment outcomes.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112631"},"PeriodicalIF":4.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.optlastec.2025.112569
Yixiong Tang , Yong Wei , Xiaoshan Li , Wei Sun , Yuye Xuan , Qiushi Huang , Yonghui Zhang , Zhihai Liu
The miniaturization development of traditional Chinese medicine active ingredient sensors still faces difficulties such as low sensitivity and inconvenient detection. This paper proposed a ring core optical fiber surface plasmon resonance (SPR) traditional Chinese medicine active ingredient sensor. The ring core with a ring width of 7 μm effectively reduces the number of transmission modes of light, and the bending degree of the core is controlled by fiber microfabrication technology to reduce the SPR incident angle and greatly improve the sensitivity of the sensor, reaching 5164 nm/RIU. Furthermore, taking the active ingredient isoquercitrin in traditional Chinese medicine as an example, its target Protein Tyrosine Phosphatase-1B (PTP1B) was immobilized on the surface of a gold membrane, achieving specific detection with a detection limit as low as 1.5 μg/L, which is comparable to high-performance liquid chromatography. The ring core fiber SPR sensor proposed in this article has the advantages of high sensitivity and short detection time, providing new ideas for the development of miniaturized, highly sensitive, and portable Chinese medicine active ingredient detection equipment.
{"title":"Ring core optical fiber SPR sensor for high-sensitivity detection of isoquercitrin","authors":"Yixiong Tang , Yong Wei , Xiaoshan Li , Wei Sun , Yuye Xuan , Qiushi Huang , Yonghui Zhang , Zhihai Liu","doi":"10.1016/j.optlastec.2025.112569","DOIUrl":"10.1016/j.optlastec.2025.112569","url":null,"abstract":"<div><div>The miniaturization development of traditional Chinese medicine active ingredient sensors still faces difficulties such as low sensitivity and inconvenient detection. This paper proposed a ring core optical fiber surface plasmon resonance (SPR) traditional Chinese medicine active ingredient sensor. The ring core with a ring width of 7 μm effectively reduces the number of transmission modes of light, and the bending degree of the core is controlled by fiber microfabrication technology to reduce the SPR incident angle and greatly improve the sensitivity of the sensor, reaching 5164 nm/RIU. Furthermore, taking the active ingredient isoquercitrin in traditional Chinese medicine as an example, its target Protein Tyrosine Phosphatase-1B (PTP1B) was immobilized on the surface of a gold membrane, achieving specific detection with a detection limit as low as 1.5 μg/L, which is comparable to high-performance liquid chromatography. The ring core fiber SPR sensor proposed in this article has the advantages of high sensitivity and short detection time, providing new ideas for the development of miniaturized, highly sensitive, and portable Chinese medicine active ingredient detection equipment.</div></div>","PeriodicalId":19511,"journal":{"name":"Optics and Laser Technology","volume":"186 ","pages":"Article 112569"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.optlastec.2025.112639
Yuhan Qu , Zhiyuan Yin , Yuanqi Sun , Xinghui Li , Deyuan Zhong , Meiting Pan , Rao Fu , Xue Zhou , Xin Yan , Yong Zhao , Tonglei Cheng
A femtosecond laser-machined few-mode fiber (FMF) laser sensor has been proposed and demonstrated for refractive index and temperature measurement in the 1.56 μm and 2 μm bands. The sensing structure consists of a slotted FMF sandwiched between two single-mode fibers (SMFs), and the multimode interference effect works as the sensing mechanism. The slotting treatment increases the evanescent field of the FMF, making it more sensitive to environmental changes, and the slot depth is optimized to obtain the superior sensing performance. Respectively in 1.56 μm and 2 μm bands, the sensor performance in terms of refractive index sensing and temperature sensing is evaluated using self-constructed fiber ring lasers, and the repeatability and stability have been validated. The slotted FMF sensor can respond to temperature and refractive index changes, which improves the application range of the sensor. Furthermore, the sensor can operate independently in two different communication bands, allowing the sensor to be optimized for specific wavelength applications and improving wavelength flexibility and selectivity. The fiber laser sensing device also possesses high signal-to-noise ratio, exceptional spectral resolution, and low operating threshold. To our knowledge, we propose a pioneering scheme that the sensor realizes parameter detection at two bands. It holds broad application prospects in the fields of biomass detection, food safety, and medical engineering in the near-infrared wavelength range.
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