心理学最新文献

Adolescence is a sensitive window for the maturation of hypothalamic-pituitary-adrenal (HPA) axis function; however, the timing and mechanisms underlying this transition remain unclear, particularly in females and in response to repeated homotypic stress. We measured corticosterone (CORT) release and glucocorticoid-related gene expression in postpubertal (P45) and adult (P75) male and female rats after acute or repeated restraint. In males, adolescents elicited higher CORT responses than adults did after acute stress, although both ages showed habituation to repeated restraint. In contrast, females exhibited adult-like CORT responses by P45 and no evidence of habituation. At the molecular level, adolescents of both sexes displayed distinct medial prefrontal cortex and ventral hippocampus expression profiles of glucocorticoid receptor (Nr3c1) and co-chaperones (Fkbp4, Fkbp5) relative to adults, though these effects were more pronounced in females, for whom there were also age- and stress-dependent changes in mineralocorticoid receptor (Nr3c2) expression. These findings suggest that while hormonal stress responses mature earlier in females than in males, sex-specific trajectories of molecular regulation continue to develop into late adolescence, potentially shaping long-term vulnerability to stress-related disorders.

Hair cortisol concentration (HCC) reflects long-term hypothalamic-pituitary-adrenal (HPA) axis activity and is a biomarker of chronic stress. Although HCC has been linked to mental health, less is known about how genetic susceptibility and early adversity jointly influence cortisol regulation, particularly in low- and middle-income countries (LMICs). This study examined whether harsh parenting predicts adolescent HCC and whether this association is moderated by genetic variation. Data were drawn from 1,823 participants in the 2004 Pelotas (Brazil) Birth Cohort, followed at ages 6, 11, and 15. Genetic data were obtained using the Illumina Global Screening Array v2, and HCC was measured at age 15 using ELISA. Harsh parenting was assessed using the Conflict Tactics Scales: Parent-Child Version, and cumulative exposure was analyzed using linear regression models. Gene-by-environment interaction analyses tested whether rs11621961 moderated the association between harsh parenting and HCC. Greater cumulative exposure to harsh parenting, particularly overall harsh parenting and corporal punishment, was associated with higher HCC at age 15. Evidence of G × E interaction indicated stronger associations among individuals carrying more copies of the T allele, suggesting a gene-dosage effect. These findings highlight how genetic susceptibility may amplify the physiological consequences of early-life stress in LMIC settings.

Posttraumatic stress disorder (PTSD) occurs after exposure to a traumatic event, leading to debilitating symptoms, including avoidance, hypervigilance, and functional impairment. There is a paucity of effective therapies to treat PTSD, partially due to the difficulty in identifying consistent underlying mechanisms. Using a modified single prolonged stress (mSPS) paradigm combined with single housing to induce both acute fear conditioning and chronic stress in mice, we developed a novel analysis method to robustly define a PTSD-like phenotype based on the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V). Following mSPS exposure, C57BL/6NHsd mice underwent behavioral testing to examine each of the criteria of PTSD according to the DSM-V. Specific parameters with the largest effect sizes between mSPS and non-mSPS mice were chosen. Absolute z-scores were generated for each behavioral parameter, and mSPS mice whose z-scores were outside the 85th confidence interval for at least one parameter for each of the eight criteria were defined as susceptible; the remainder of the exposed mice were considered resilient. Finally, resilient mice were evaluated for anhedonia and hyperlocomotive behaviors. The results demonstrated that a PTSD-like phenotype can be robustly defined in mice based on all 8 DSM-V criteria. Importantly, 29.76% of mSPS mice were classified as susceptible, which is similar to the incidence observed in humans exposed to trauma. This novel behavioral analysis method may assist in better defining a PTSD-like phenotype, identifying a more robust population, which may help facilitate the discovery of the underlying mechanism(s) of PTSD and its association with other comorbidities.

Early Life Stress (ELS) increases the risk for mental health issues in humans, notably in major depression and anxiety disorders. ELS is frequently modeled in laboratory rodents by disrupting the early postnatal environment. Literature on ELS is expanding, yet studies on sex-specific differences remain mixed. We utilized a novel ELS protocol that subjected mouse pups of both sexes to maternal separation and removed pup-to-pup contact comfort during postnatal days 10 to 17. We hypothesized that this ELS protocol would induce depressive and anxiety-like phenotypes persisting into adulthood, with greater vulnerability in females. A second cohort reared under normal conditions until adulthood was subjected to forced swim, mimicking adult-onset stress (AS). ELS, AS, and control animals (reared under normal conditions) underwent open field, social interaction, and tail suspension tests. In open field, AS mice spent significantly less time in center than controls. Social interaction showed significant effects of treatment and sex, with stress exposure increasing familiar-mouse interaction time and reducing the sex difference observed in controls. Tail suspension testing revealed a significant decrease in latency to immobility for stress groups compared to controls. Total time immobile showed significant group and interaction effects, with stress groups showing more time immobile. Both social interaction and tail suspension revealed a sex difference in controls, eliminated in stress groups. This ELS protocol produces lasting alterations in adult social and coping-related behaviors and demonstrates multiple sex-specific outcomes.

Emotion regulation research has routinely pitted the antecedent-focused strategy of cognitive reappraisal against the response-focused strategy of expressive suppression. This research has largely yielded that reappraisal is an effective strategy by which to change emotional experience, but implications of expressive suppression are not as clear. This may be due to variations in experimental methodologies, which have not consistently evaluated suppression against a within-subject control condition, as well as conceptual limitations that have muddled the implications of significant findings. Across two high-powered, within-subject paradigms, the present study demonstrates that expressive suppression induces significant decreases in negative emotion relative to one's general attempts to downregulate negative emotion (Study 1) and respond naturally (Study 2). Our findings add to a growing body of literature that demonstrate that suppression may facilitate emotion regulation at both the expressive and experiential levels, and underscore the importance of incorporating flexibility and goal-focused frameworks in future research.

People hold different beliefs about the changeability of happiness. Some believe that happiness is biologically predetermined and thus unchangeable (essentialist beliefs), while others believe that it is malleable and can be changed (non-essentialist beliefs). Do these beliefs have a tangible impact on how individuals actually experience well-being? Here, we predict and empirically demonstrate that endorsing essentialist beliefs about happiness (EBH) can result in a self-fulfilling prophecy that buffers the changes in subjective well-being (SWB) following life events. Through a series of four studies utilizing diverse methodologies (total N = 7,364), we provide converging evidence that happiness essentialists, compared to non-essentialists, experience relatively stable levels of SWB following life events, particularly negative ones. We find that this pattern also emerges when people recall past events or anticipate hypothetical or impending future events. Together, happiness essentialism extends beyond mere belief and has real-world implications for how individuals experience fluctuations in SWB.

Research suggests that belonging to multiple groups and trust separately mitigate psychological distress in response to adversity. However, their combined influence, particularly over time, in the context of unwanted sexual experiences during mass gatherings has not been fully explored. To advance our understanding, we investigated whether multiple group membership prior to a youth mass gathering was associated with lower psychological distress, and if trust in friends at the mass gathering (i.e., ingroup trust) explained this relationship among young people who either reported or did not report an unwanted sexual experience. Drawing on data from a longitudinal field study of young people attending a mass gathering, Schoolies (N = 97), we assessed participants' multiple group memberships prior to the mass gathering (T1) and measured ingroup trust and psychological distress during the mass gathering (T2). Our findings revealed that 64.9% of participants reported unwanted sexual experiences at the mass gathering. Among those who reported unwanted sexual experiences, moderated mediation analysis indicated that belonging to multiple groups at T1 was associated with greater ingroup trust at T2, which in turn was linked to lower psychological distress at T2. This study provides evidence that multiple group membership may provide important psychological resources necessary for protecting against psychological distress following unwanted sexual experiences. Further, it highlights how group memberships might be thought of as latent psychological resources in the context of adverse experiences.

The consistently high prevalence of unwanted sexual experiences (USEs) on university campuses has led to increasing calls for evidence-based solutions to inform policies, training, and intervention development. However, Research Ethics Committees are often hesitant to approve sexual trauma research due to beliefs that asking participants about traumatic experiences will cause extreme distress. Conversely, previous literature has found that many participants who have experienced sexual trauma report positive reactions following their participation in such research. Studies have found that while immediate negative emotional reactions are common, this distress is short-term (e.g., lasting only minutes or hours after participation). The present study assessed 469 Northern Irish university students' experiences of participating in research addressing USEs. The findings indicated that participating in USE research was a positive experience for participants, regardless of victimization status. Further, participants who reported a victimization experience did not report experiencing a negative emotional reaction to participating in the study. This article considers the ethics of conducting sexual trauma research among university students, with reference to common ethical concerns that can be addressed as part of the research process.

The aim of this study is to provide a test that allows for evaluation of both semantic memory (SM) and episodic memory (EM). The study sought to examine psychometric characteristics of the Modified Dead-Alive Test (M-DAT) in patients with neurocognitive disorders and the healthy elderly (HE). The M-DAT consists of 45 names of celebrities who have died in the remote past (15), died in the last five years (15), and are still alive (15), and participants are asked whether they are alive or dead. The M-DAT performances of patients with Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) major neurocognitive disorder due to Alzheimer's Disease (MND-AD) (n = 69) and patients with minor neurocognitive disorder (MiND) (n = 27) who were admitted to a geriatric psychiatry clinic and healthy controls (HC) (n = 29) were compared. Age and level of education were taken as covariates, and an analysis of covariance (ANCOVA) was performed since the MND-AD group was older and less educated. The MND-AD group had lower performance in EM and SM scores of the M-DAT. M-DAT failed to differentiate between MiND and HE. Both subscale scores of the M-DAT were associated with other neuropsychological test performances as well as the level of education. The results suggest that M-DAT is a valid and reliable tool that examines both EM and SM performances. M-DAT is an alternative for the assessment of SM evaluated by verbal fluency or naming tests. Evaluating EM and SM together is an important advantage; however, M-DAT is influenced by education, and the items require updating.

Objective: The study aimed to carry out a cross-cultural analysis by comparing Five-Point test scores for two different countries. The Five-Point test measures design fluency, an executive function, and is an inexpensive test that makes it more accessible to assessment settings, including under-resourced settings.

Methods: Adults in Argentina (n = 90) and South Africa (n = 90) with tertiary levels of education were tested on the Five-Point Test. ANOVA was applied to compare the scores of the two groups on the total number of unique designs produced (Total Unique Designs).

Results: The study found no significant differences in the Total Unique Designs scores between the two groups (p = .13; η = 0.01). Correlations between demographic variables and the Total Unique Designs scores varied slightly across both samples.

Conclusions: Despite large cultural differences between both samples (language, race, religion, income) scores on this test did not differ significantly. These findings provide initial evidence of scalar equivalence on the test across these samples. Norms for the Five-Point Test Total Unique Designs scores might be used interchangeably between these two highly educated groups from different countries.