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Economic DAO governance: A contestable control approach 经济DAO治理:一种可争议的控制方法
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100306
Jeff Strnad
In this article, we propose a new form of decentralized autonomous organization (DAO) governance that uses a sequential auction mechanism to overcome the entrenched control issues that have emerged for DAOs by creating a regime of temporary contestable control. The mechanism avoids potential public choice problems inherent in voting approaches but at the same time provides a vehicle that can enhance and secure value that inheres to DAO voting and other DAO non-market governance procedures. It is robust to empty voting and is code feasible. The mechanism not only facilitates the ability of DAOs to meet their normative and operational goals in the face of diverse regulatory approaches, but also strengthens the case for creating a less burdensome but at least equally effective regulatory regime for DAOs that employ the mechanism. Designed to shift control to the party with the most promising business plan, at the same time, it deters value destruction by control parties, maximizes social surplus, and distributes that surplus in a way that tends to promote investment by other parties both at start up and on an ongoing basis.
在本文中,我们提出了一种新的去中心化自治组织(DAO)治理形式,它使用顺序拍卖机制,通过创建临时可争议控制机制来克服DAO出现的根深蒂固的控制问题。该机制避免了投票方式固有的潜在公共选择问题,同时提供了一种工具,可以增强和保护DAO投票和其他DAO非市场治理程序固有的价值。它对空投票具有鲁棒性,并且代码可行。该机制不仅促进了dao在面对各种监管方法时实现其规范和运营目标的能力,而且还加强了为采用该机制的dao创建一个负担较少但至少同样有效的监管制度的理由。它旨在将控制权转移给最有希望的商业计划的一方,同时,它阻止了控制权方的价值破坏,最大化了社会剩余,并以一种倾向于促进其他各方在启动和持续基础上投资的方式分配剩余。
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引用次数: 0
Environmental pathways and drivers of antimicrobial resistance in waterborne Escherichia coli in Pakistan: a one health perspective 巴基斯坦水源性大肠杆菌抗菌素耐药性的环境途径和驱动因素:一个健康观点
Q1 Social Sciences Pub Date : 2025-09-01 DOI: 10.1016/j.jobb.2025.08.001
Adnan Khan , Shahbaz Ahmad Zakki , Ijaz ul Haq , Muhammad Shahzad , Nauman Khan

Background

Antimicrobial resistance (AMR) is a global health crisis requiring a One Health approach to integrate surveillance across sectors, particularly in water sources, to control its spread. Considering socioeconomic and environmental factors, this study explored Escherichia coli and AMR patterns in water using a One Health approach.

Methodology

This cross-sectional study assessed E. coli and AMR in drinking and sewerage water across three districts in Khyber Pakhtunkhwa, Pakistan. Multi-stage random sampling yielded 840 water samples from 420 households, along with socio-demographic and AMR awareness data. Microbiological analyses identified E. coli, CRE, and ESBL. The resistance profiles were determined using the disk diffusion method, and the association between socio-demographics and awareness was analyzed.

Results

The prevalence of E. coli in drinking water was 44 %, with 40 % ESBL, 21 % CRE, and 15 % co-occurrence of ESBL and CRE. Swat had the highest E. coli prevalence in sewerage (78 %) and drinking water (58 %), while Bannu had the highest ESBL levels. Tetracycline resistance was widespread (78 % sewerage and 69 % drinking water). The MAR index showed that 20.5 % of the isolates were resistant to six antibiotics, varying by district. Location influenced the contamination level (p = 0.002). Access to health (OR = 0.497), veterinary services (OR = 0.881), and frequent medical advice (OR = 1.557) lowered E. coli contamination. Education (p = 0.002) and locality (p < 0.001) affected AMR knowledge. Animal area cleaning was significantly correlated with AMR awareness.

Conclusion

High E. coli and AMR levels in water pose public health risks because they are driven by poor sanitation, limited water access, and low awareness. Better water management, awareness, and antimicrobial control are essential to mitigate AMR spread.
抗生素耐药性(AMR)是一项全球卫生危机,需要采取“同一个健康”方针,将跨部门监测整合起来,特别是在水源领域,以控制其传播。考虑到社会经济和环境因素,本研究使用“同一个健康”方法探索了水中大肠杆菌和抗菌素耐药性的模式。方法:本横断面研究评估了巴基斯坦开伯尔普赫图赫瓦省三个地区饮用水和污水中的大肠杆菌和抗菌素耐药性。多阶段随机抽样从420个家庭获得840个水样,以及社会人口统计和抗菌素耐药性认识数据。微生物学分析鉴定出大肠杆菌、CRE和ESBL。采用盘片扩散法测定抗性分布,并分析社会人口统计学与认知的关系。结果饮用水中大肠杆菌感染率为44%,其中ESBL为40%,CRE为21%,ESBL和CRE共发病15%。斯瓦特的污水和饮用水中大肠杆菌感染率最高(78%),而班努的ESBL水平最高。四环素耐药性普遍存在(污水78%,饮用水69%)。MAR指数显示,20.5%的分离株对6种抗生素耐药,各地区差异较大。地点影响污染程度(p = 0.002)。获得卫生服务(OR = 0.497)、兽医服务(OR = 0.881)和频繁的医疗建议(OR = 1.557)降低了大肠杆菌污染。教育(p = 0.002)和地区(p < 0.001)影响AMR知识。动物区域清洁与抗菌素耐药性意识显著相关。结论水体中大肠杆菌和抗菌素耐药性的高水平存在公共卫生风险,其原因是卫生条件差、取水渠道有限和意识不高。更好的水管理、意识和抗菌素控制对于减轻抗菌素耐药性的传播至关重要。
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引用次数: 0
Strengthening national biosafety capabilities and enhancing global biosafety governance 加强国家生物安全能力建设,加强全球生物安全治理
Q1 Social Sciences Pub Date : 2025-09-01 DOI: 10.1016/j.jobb.2025.09.001
Chao Shan, Yuan Zhiming
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引用次数: 0
Rug pull detection on decentralized exchange using transaction data 基于交易数据的去中心化交易的Rug pull检测
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100275
Suparat Srifa , Yury Yanovich , Robert Vasilyev , Tharuka Rupasinghe , Vladislav Amelin
Cryptocurrency has transformed finance and investment, with platforms like Uniswap facilitating billions of dollars in trades. However, malicious smart contracts and scam tokens have led to significant financial losses for decentralized finance (DeFi) users. Code analysis alone cannot detect rug pulls using social engineering tactics. To address this issue, machine learning algorithms can leverage the vast amount of transactional data stored on the blockchain, particularly time series data, to identify scam tokens. This study aims to determine the optimal timeframe for detecting rug pulls and highlights the importance of token volume and transaction count features. The findings suggest that shorter timeframes are sufficient for detecting rug pull tokens since most incidents occur soon after token creation. This research offers new insights into scam token classification and prevention and contributes to a broader understanding of this field.
加密货币已经改变了金融和投资,像Uniswap这样的平台促成了数十亿美元的交易。然而,恶意智能合约和诈骗代币给去中心化金融(DeFi)用户带来了重大的经济损失。仅靠代码分析无法发现使用社会工程策略的作弊行为。为了解决这个问题,机器学习算法可以利用存储在区块链上的大量事务数据,特别是时间序列数据,来识别诈骗令牌。本研究旨在确定检测rug pull的最佳时间框架,并强调令牌数量和交易计数特征的重要性。研究结果表明,较短的时间范围足以检测rug pull令牌,因为大多数事件发生在令牌创建后不久。这项研究为诈骗令牌分类和预防提供了新的见解,并有助于更广泛地了解这一领域。
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引用次数: 0
The association between TMPRSS2 gene rs2070788 and rs12329760 variants and COVID-19 susceptibility and severity: A study from Jordan 来自约旦的TMPRSS2基因rs2070788和rs12329760变异与COVID-19易感性和严重程度的关系
Q1 Social Sciences Pub Date : 2025-09-01 DOI: 10.1016/j.jobb.2025.08.003
Sara S.H. Abu Zaid , Omar F. Khabour , Sawsan Abuhammad
Symptoms of coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), range from asymptomatic to life-threatening, affecting the respiratory system and many other organs, and involved in SARS-CoV-2 pathogenesis, particularly its viral entry, is the enzyme transmembrane protease serine 2 (TMPRSS2). In response, in this study, polymorphisms in the TMPRSS2 gene (rs2070788 and rs12329760) were examined for their association with COVID-19 susceptibility and severity in Jordanians. The study participants (n = 861) included 427 individuals who had never contracted COVID-19 (control group) and 434 who had experienced the disease (case group). The case group was subsequently divided into two subgroups: severe (n = 166) and non-severe (n = 268) COVID-19. The results show that rs2070788 is associated with disease susceptibility in all inheritance models (P < 0.05), as well as an association between rs12329760 and COVID-19 disease severity in both the dominant and over-dominant models (P < 0.05). Further, a higher body mass index (BMI) and older age were associated with disease severity (p < 0.05), though females were less likely to develop severe COVID-19 and to be hospitalized. In conclusion, polymorphisms in the TMPRSS2 gene may be considered a potential predictor of COVID-19 outcomes in the Jordanian population. The study findings could be used to manage similar viral infections in Jordan in the future.
由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的2019年冠状病毒病(COVID-19)的症状从无症状到危及生命不等,影响呼吸系统和许多其他器官,并且参与SARS-CoV-2的发病机制,特别是其病毒进入酶是跨膜蛋白酶丝氨酸2 (TMPRSS2)。为此,本研究检测了约旦人TMPRSS2基因(rs2070788和rs12329760)多态性与COVID-19易感性和严重程度的关系。研究参与者(n = 861)包括427名从未感染过COVID-19的人(对照组)和434名经历过这种疾病的人(病例组)。病例组随后被分为两个亚组:重症(n = 166)和非重症(n = 268) COVID-19。结果显示,rs2070788在所有遗传模型中均与疾病易感性相关(P < 0.05), rs12329760在显性和过显性模型中均与COVID-19疾病严重程度相关(P < 0.05)。此外,较高的身体质量指数(BMI)和年龄与疾病严重程度相关(p < 0.05),尽管女性发展为严重的COVID-19和住院的可能性较低。总之,TMPRSS2基因的多态性可能被认为是约旦人群中COVID-19结局的潜在预测因子。研究结果可以用于未来在约旦管理类似的病毒感染。
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引用次数: 0
Privacy-preserving and automated intellectual property license agreements over heterogeneous blockchain networks 异构区块链网络上的隐私保护和自动知识产权许可协议
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100288
Damiano Di Francesco Maesa , Matteo Loporchio , Frank Tietze
This paper considers the application scenario of Intellectual Property (IP) management, a business process yet to fully embrace digitisation and the advantages it brings. We propose to leverage Distributed Ledger Technology (DLT) to digitise license agreements management by providing automated and trustworthy royalty computation, transaction execution, and payment distribution. This can be achieved by employing smart licenses, i.e., bundles of smart contracts implementing the royalty logic of license agreements. To provide scalability, flexibility, and resilience, we propose to deploy smart licenses on a network of networks model, i.e., a set of heterogeneous networks potentially running different DLT protocols and connected by cross-chain information exchange protocols. A novel advantage of the network of networks approach is that it allows for the use of private values for royalty computation, which is impossible in the traditional model. Of course, supporting private DLT networks requires privacy-preserving cross-chain schemes, a still open problem in the literature. This is why we present two alternative privacy-preserving cross-chain schemes for our considered application scenario of license agreements management, one based on Homomorphic Encryption (HE) and the other on Zero-Knowledge (ZK) proofs. Besides discussing their theoretical advantages and drawbacks, we present an experimental evaluation of a prototype implementation of smart licenses based on both schemes.
本文考虑了知识产权(IP)管理的应用场景,这是一个尚未完全拥抱数字化的业务流程及其带来的优势。我们建议利用分布式账本技术(DLT),通过提供自动化和可信的版税计算、交易执行和支付分发,将许可协议管理数字化。这可以通过使用智能许可来实现,即,实现许可协议的版税逻辑的智能合约束。为了提供可扩展性、灵活性和弹性,我们建议在网络模型的网络上部署智能许可,即一组可能运行不同DLT协议并通过跨链信息交换协议连接的异构网络。网络的网络方法的一个新优点是它允许使用私有值进行版税计算,这在传统模型中是不可能的。当然,支持私有DLT网络需要保护隐私的跨链方案,这在文献中仍然是一个开放的问题。这就是为什么我们为许可协议管理的应用场景提出了两种可选的保护隐私的跨链方案,一种基于同态加密(HE),另一种基于零知识(ZK)证明。除了讨论它们的理论优缺点外,我们还对基于这两种方案的智能许可原型实现进行了实验评估。
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引用次数: 0
Towards blockchain interoperability: a comprehensive survey on cross-chain solutions 迈向区块链互操作性:跨链解决方案的综合调查
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100286
Wenqing Li , Zhenguang Liu , Jianhai Chen , Zhe Liu , Qinming He
The rapid expansion of decentralized finance (DeFi) applications has catalyzed the emergence of new blockchain systems at an unprecedented pace. However, these systems are largely evolving in isolation, hindering the development of a cohesive ecosystem where value and data can flow seamlessly across networks. Blockchain interoperability technologies are introduced to break down these communication barriers and facilitate effective interactions between different blockchain systems. In recent years, numerous approaches and solutions to blockchain interoperability have been proposed. While some reviews have attempted to categorize cross-chain solutions based on blockchain standards and architectures, a more in-depth analysis is warranted. In this work, we investigate mainstream cross-chain solutions from the perspective of their principles, applications, protocols, and performance. To clarify the concept of blockchain interoperability, we propose a conceptual model that characterizes both asset interoperability and data interoperability. Furthermore, we introduce a hierarchical architecture to categorize and analyze representative cross-chain solutions, covering both academic research and industrial implementations. To maximize the utility of this review for a wide audience, we also highlight open challenges and identify future directions in the field of blockchain interoperability, expecting to provide a comprehensive overview of cross-chain solutions.
去中心化金融(DeFi)应用的迅速扩张,催化了新的区块链系统以前所未有的速度出现。然而,这些系统在很大程度上是孤立发展的,阻碍了价值和数据可以在网络上无缝流动的凝聚力生态系统的发展。区块链互操作性技术的引入打破了这些通信障碍,促进了不同区块链系统之间的有效交互。近年来,已经提出了许多实现区块链互操作性的方法和解决方案。虽然一些评论试图根据区块链标准和体系结构对跨链解决方案进行分类,但有必要进行更深入的分析。在这项工作中,我们从其原理、应用、协议和性能的角度研究了主流的跨链解决方案。为了阐明区块链互操作性的概念,我们提出了一个概念模型,该模型同时描述了资产互操作性和数据互操作性。此外,我们引入了一个层次结构来分类和分析具有代表性的跨链解决方案,涵盖了学术研究和工业实现。为了最大限度地为广大受众提供本综述的效用,我们还强调了区块链互操作性领域的开放挑战并确定了未来的方向,期望提供跨链解决方案的全面概述。
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引用次数: 0
WASIF: In-depth detection of vulnerabilities in Wasm smart contracts via information flows and function invocation sequences WASIF:通过信息流和函数调用序列深入检测Wasm智能合约中的漏洞
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100287
Chu Chen , Xuan Wang , Bin Yu , Yumo Tian , Xiaoyu Lu , Pinghong Ren , Jin Liu
With the widespread adoption of WebAssembly (Wasm) smart contracts in popular blockchain platforms such as EOSIO, vulnerability attacks on Wasm smart contracts have become a serious problem. To protect the legitimate interests of blockchain users, it is necessary to detect vulnerabilities in Wasm smart contracts. However, detection faces a great challenge in that the source code of Wasm smart contracts is rarely released publicly. Although many approaches have made great progress in vulnerability detection, they still suffer from inefficiently generating function invocation sequences to track inter-function dependencies, ineffectively tracking sensitive information flows, and a considerable number of False Positives (FPs). To address these issues, we present a new concolic fuzzing approach for detecting vulnerabilities in Wasm smart contracts via information flows and function invocation sequences, namely, WASIF. Also, we implement the open-source prototype of the WASIF and conduct extensive experiments to evaluate it. The experimental results show that WASIF effectively and efficiently detects vulnerabilities in Wasm smart contracts and outperforms the state-of-the-art concolic fuzzer WASAI on most metrics.
随着WebAssembly (Wasm)智能合约在流行的区块链平台(如EOSIO)上的广泛采用,针对Wasm智能合约的漏洞攻击已经成为一个严重的问题。为了保护区块链用户的合法权益,有必要检测Wasm智能合约中的漏洞。然而,Wasm智能合约的源代码很少公开发布,这给检测带来了很大的挑战。尽管许多方法在漏洞检测方面取得了很大的进展,但它们仍然存在生成函数调用序列以跟踪功能间依赖关系的效率低下、跟踪敏感信息流的效率低下以及大量误报(FPs)的问题。为了解决这些问题,我们提出了一种新的concolic模糊方法,通过信息流和函数调用序列来检测Wasm智能合约中的漏洞,即WASIF。此外,我们实现了WASIF的开源原型,并进行了广泛的实验来评估它。实验结果表明,WASIF有效且高效地检测Wasm智能合约中的漏洞,并且在大多数指标上优于最先进的concolic fuzzer WASAI。
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引用次数: 0
A Layer-2 expansion shared sequencer model for blockchain scalability 区块链可扩展性的第二层扩展共享序列器模型
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-09-01 DOI: 10.1016/j.bcra.2025.100292
Huijian Han , Mingwei Wang , Feng Yang , Linpeng Jia , Yi Sun , Rui Zhang
Rollup stands out as one of the most effective techniques for blockchain Layer-2 scaling. By processing transactions off-chain, it significantly enhances the throughput. However, the most rollup implementations currently rely on centralized sequencers, exposing the system and users to censorship attacks and risking network paralysis. In contrast, fully decentralized sequencers encounter latency issues and reduced throughput during the consensus phase. We propose a multislot weighted leader election algorithm based on shared sequencers, apply the proposer–builder separation (PBS) model, and use the fuzzy cognitive map (FCM) to analyze and optimize the important influence parameters. With its low trust dependence and high functionality, the probability of selecting malicious nodes is reduced. The sequencing and consensus are separated, so that the transaction can quickly reach soft confirmation. We implement this algorithm in a shared sequencer prototype. The experimental results show that the proposed algorithm parameter settings are in line with the expectations, and the probability of electing malicious nodes is significantly reduced. The transactions per second (TPS) of the network can cope with the throughput requirements of the Layer-2.
Rollup是区块链第2层扩展最有效的技术之一。通过处理链下交易,它显著提高了吞吐量。然而,大多数rollup实现目前依赖于集中式测序器,这将系统和用户暴露于审查攻击之下,并有网络瘫痪的风险。相比之下,完全分散的测序器在共识阶段遇到延迟问题和吞吐量降低。提出了一种基于共享序列的多时隙加权领袖选举算法,采用提议者-构建者分离(PBS)模型,并利用模糊认知图(FCM)对重要影响参数进行分析和优化。该算法具有较低的信任依赖性和较高的功能性,降低了选择恶意节点的概率。排序和共识分离,使交易能够快速达到软确认。我们在一个共享的音序器原型中实现了这个算法。实验结果表明,提出的算法参数设置符合预期,显著降低了恶意节点的当选概率。网络的TPS (transactions per second)可以满足第二层的吞吐量要求。
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引用次数: 0
Corrigendum to “Dynamic exponent market maker: personalized portfolio manager and one pool to trade them all” “动态指数做市商:个性化投资组合经理和一个交易池”的勘误表
IF 5.6 3区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2025-08-19 DOI: 10.1016/j.bcra.2025.100358
Wittawat Kositwattanarerk
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引用次数: 0
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