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Endocrine therapy and urogenital outcomes among women with a breast cancer diagnosis. 内分泌治疗与确诊乳腺癌妇女的泌尿生殖系统结果。
IF 2.3 Q2 Computer Science Pub Date : 2016-11-01 Epub Date: 2016-09-28 DOI: 10.1007/s10552-016-0810-x
Suzanne N Landi, Kemi M Doll, Jeannette T Bensen, Laura Hendrix, Carey K Anders, Jennifer M Wu, Hazel B Nichols

Purpose: Endocrine therapy for breast cancer can exacerbate menopausal symptoms. The association between endocrine therapy and common pelvic floor disorders including urinary incontinence has rarely been evaluated. We examined urogenital and sexual side effects among women with a breast cancer diagnosis, comparing endocrine therapy users to nonusers.

Methods: Urogenital and sexual symptoms were self-reported during the enrollment interview within the University of North Carolina Cancer Survivorship Cohort. Tumor characteristics and endocrine therapy use were collected from medical and prescription records. We calculated multivariable prevalence ratios (PR) and 95 % confidence intervals (CI) for the association of endocrine therapy (versus no endocrine therapy) and urinary incontinence, overall and by therapy type (tamoxifen or aromatase inhibitors). PROMIS Sexual Function and Satisfaction domain scores were compared across endocrine therapy groups.

Results: Among the 548 women with a breast cancer diagnosis, 49 % received endocrine therapy. Overall, 18 % of women reported urinary incontinence symptoms. We observed no association between urinary incontinence and endocrine therapy use overall (PR = 0.97; 95 % CI 0.67, 1.43), tamoxifen (PR = 1.20; 95 % CI 0.74, 1.96), or aromatase inhibitors (PR = 0.89; 95 % CI 0.55, 1.42), compared to no use. Approximately 55 % of women were sexually active. Sexual function scores did not vary according to endocrine therapy use, although urinary incontinence was associated with lower satisfaction scores (p = 0.05).

Conclusions: Our findings demonstrate a high prevalence of urinary incontinence after breast cancer diagnosis similar to the overall prevalence in older U.S. women, and this did not vary strongly according to use of endocrine therapy.

目的:乳腺癌内分泌治疗会加重更年期症状。内分泌治疗与包括尿失禁在内的常见盆底疾病之间的关系很少被评估。我们对确诊为乳腺癌的妇女的泌尿生殖系统和性功能副作用进行了研究,并将内分泌治疗使用者与非使用者进行了比较:方法:在北卡罗来纳大学癌症幸存者队列(University of North Carolina Cancer Survivorship Cohort)中,泌尿生殖系统和性症状都是在入组访谈时自我报告的。肿瘤特征和内分泌治疗使用情况来自医疗和处方记录。我们计算了内分泌治疗(相对于未接受内分泌治疗)与尿失禁的多变量患病率比 (PR) 和 95 % 置信区间 (CI),包括总体患病率比和治疗类型(他莫昔芬或芳香化酶抑制剂)。对不同内分泌治疗组的 PROMIS 性功能和满意度领域得分进行了比较:在 548 名确诊为乳腺癌的女性中,49% 接受了内分泌治疗。总体而言,18%的女性报告有尿失禁症状。我们观察到,与未使用内分泌治疗相比,尿失禁与使用内分泌治疗的总体比例(PR = 0.97; 95 % CI 0.67, 1.43)、他莫昔芬(PR = 1.20; 95 % CI 0.74, 1.96)或芳香化酶抑制剂(PR = 0.89; 95 % CI 0.55, 1.42)之间没有关联。约 55% 的女性性生活活跃。尽管尿失禁与较低的满意度评分有关(P = 0.05),但性功能评分并未因使用内分泌治疗而有所不同:我们的研究结果表明,乳腺癌确诊后尿失禁的发病率很高,与美国老年妇女的总体发病率相似,而且这种情况并不因使用内分泌疗法而有很大不同。
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引用次数: 0
Robust Approximations to Joint Chance-constrained Problems 联合机会约束问题的鲁棒逼近
Q2 Computer Science Pub Date : 2015-10-01 DOI: 10.1016/S1874-1029(15)30003-3
Ran DING , Guo-Xiang LI , Qi-Qiang LI

Two new approximate formulations to joint chance-constrained optimization problems are proposed in this paper. The relationships of CVaR (conditional-value-at-risk), chance constrains and robust optimization are reviewed. Firstly, two new upper bounds on E((·) +) are proposed, where E stands for the expectation and x+ = max(0, x), based on which two approximate formulations for individual chance-constrained problems are derived. The approximations are proved to be the robust optimization with the corresponding uncertain sets. Then the approximations are extrapolated to joint chance-constrained problem. Finally numerical studies are performed to compare the solutions of individual and joint chance constraints approximations and the results demonstrate the validity of our method.

本文提出了联合机会约束优化问题的两个新的近似表达式。讨论了条件风险值(CVaR)、机会约束和鲁棒优化之间的关系。首先,提出了E((·)+)的两个新的上界,其中E代表期望,x+ = max(0, x),并在此基础上导出了个别机会约束问题的两个近似表达式。证明了该逼近是具有相应不确定集的鲁棒优化。然后将近似外推到关节机会约束问题。最后通过数值计算比较了个别约束近似和联合约束近似的解,结果证明了本文方法的有效性。
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引用次数: 1
A Chebyshev-Gauss Pseudospectral Method for Solving Optimal Control Problems 求解最优控制问题的切比舍夫-高斯伪谱法
Q2 Computer Science Pub Date : 2015-10-01 DOI: 10.1016/S1874-1029(15)30004-5
Xiao-Jun TANG , Jian-Li WEI , Kai CHEN

A pseudospectral method is presented for direct trajectory optimization of optimal control problems using collocation at Chebyshev-Gauss points, and therefore, it is called Chebyshev-Gauss pseudospectral method. The costate and constraint multiplier estimates for the proposed method are rigorously derived by comparing the discretized optimality conditions of an optimal control problem with the Karush-Kuhn-Tucker conditions of the resulting nonlinear programming problem from collocation. The distinctive advantages of the proposed method over other pseudopsectral methods are the good numerical stability and computational efficiency. In order to achieve this goal, the barycentric Lagrange interpolation is substituted for the classic Lagrange interpolation in the state approximation. Furthermore, a simple yet efficient method is presented to alleviate the numerical errors of state differential matrix using the trigonometric identity especially when the number of Chebyshev-Gauss points is large. The method presented in this paper has been taken to two optimal control problems from the open literature, and the results have indicated its ability to obtain accurate solutions to complex constrained optimal control problems.

针对最优控制问题的直接轨迹优化问题,提出了一种利用切比雪夫-高斯点配置的伪谱方法,因此称为切比雪夫-高斯伪谱方法。通过比较最优控制问题的离散化最优性条件和由配置产生的非线性规划问题的Karush-Kuhn-Tucker条件,严格推导了该方法的域态估计和约束乘子估计。与其他伪谱方法相比,该方法具有较好的数值稳定性和计算效率。为了达到这一目的,在状态逼近中用重心拉格朗日插值代替经典拉格朗日插值。在此基础上,提出了一种利用三角恒等式简化状态微分矩阵数值误差的方法,特别是在切比雪夫-高斯点数目较大的情况下。本文所提出的方法已应用于公开文献中的两个最优控制问题,结果表明该方法能够获得复杂约束最优控制问题的精确解。
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引用次数: 9
SAR Image Despeckling by Sparse Reconstruction Based on Shearlets 基于shearlet的SAR图像去斑稀疏重建
Q2 Computer Science Pub Date : 2015-08-01 DOI: 10.1016/S1874-1029(15)30002-1
Jian JI , Xiao LI , Shuang-Xing XU , Huan LIU , Jing-Jing HUANG

Synthetic aperture radar (SAR) image is usually polluted by multiplicative speckle noise, which can affect further processing of SAR image. This paper presents a new approach for multiplicative noise removal in SAR images based on sparse coding by shearlets filtering. First, a SAR despeckling model is built by the theory of compressed sensing (CS). Secondly, obtain shearlets coefficient through shearlet transform, each scale coefficient is represented as a unit. For each unit, sparse coefficient is iteratively estimated by using Bayesian estimation based on shearlets domain. The represented units are finally collaboratively aggregated to construct the despeckling image. Our results in SAR image despeckling show the good performance of this algorithm, and prove that the algorithm proposed is robustness to noise, which is not only good for reducing speckle, but also has an advantage in holding information of the edge.

合成孔径雷达(SAR)图像经常受到乘性散斑噪声的污染,影响SAR图像的进一步处理。提出了一种基于shearlet滤波稀疏编码的SAR图像乘性去噪方法。首先,利用压缩感知理论建立SAR去斑模型;其次,通过shearlet变换得到shearlet系数,将每个尺度系数表示为一个单位。对于每个单元,采用基于shearlets域的贝叶斯估计迭代估计稀疏系数。最后将表示的单元协同聚合以构建去斑图像。SAR图像去斑的实验结果表明了该算法的良好性能,并证明了该算法对噪声具有较强的鲁棒性,不仅能很好地去除散斑,而且在保留边缘信息方面具有优势。
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引用次数: 9
Forward Affine Point Set Matching Under Variational Bayesian Framework 变分贝叶斯框架下的正向仿射点集匹配
Q2 Computer Science Pub Date : 2015-08-01 DOI: 10.1016/S1874-1029(15)30001-X
Han-Bing QU , Xi CHEN , Song-Tao WANG , Ming YU

In this work, the affine point set matching is formulated under a variational Bayesian framework and the model points are projected forward into the scene space by a linear transformation. A directed acyclic graph is presented to represent the relationship between the parameters, latent variables, model and scene point sets and an iterative approximate algorithm is proposed for the estimation of the posterior distributions over parameters. Furthermore, the anisotropic covariance is assumed on the transition variable and one Gaussian component is provided for the inference of outlier points. Experimental results demonstrate that the proposed algorithm achieves good performance in terms of both robustness and accuracy.

在此工作中,在变分贝叶斯框架下建立仿射点集匹配,并通过线性变换将模型点前投影到场景空间中。提出了一个有向无环图来表示参数、潜在变量、模型和场景点集之间的关系,并提出了一种估计参数后验分布的迭代近似算法。此外,在过渡变量上假定各向异性协方差,并提供一个高斯分量用于离群点的推断。实验结果表明,该算法在鲁棒性和准确性方面都取得了较好的效果。
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引用次数: 1
H. S. Tsien s Concept for Intelligence and Parallel Intelligence:From LASER to Inspiritment 钱学森的智能与平行智能概念:从激光到灵感
Q2 Computer Science Pub Date : 2015-01-01 DOI: 10.16383/J.AAS.2015.C150216
Wang, Fei-Yue
Fifty years ago in 1964, H. S. Tsien translated LASER into Ji Guang for a Chinese intelligence magazine on light amplification by stimulated emission of radiation. 20 years later from this event in 1983, Tsien proposed a concept for intelligence called "information inspiritment" or Ji Huo in Chinese, with the desire to make intelligence as "LASER Intelligence" so that it will be like "the sharpest knife, the brightest light, the most accurate rule" for decision and action.This paper discusses Tsien s idea of inspiration and parallel intelligence and how to implement "intelligence inspiritors"based on ACP theory.
五十年前的1964年,钱学森为一本中国情报杂志翻译了《激光》(LASER)的译名《季光》(Ji Guang)。20年后的1983年,钱存训提出了“信息启发”的智能概念,希望将智能变成“激光智能”,使其像“最锋利的刀,最明亮的光,最准确的规则”一样,用于决策和行动。本文以ACP理论为基础,探讨了钱学森的激励与平行智能思想,以及如何实施“智能激励”。
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引用次数: 1
An identification method for nonlinear systems with colored measurement noise 有色测量噪声非线性系统的识别方法
Q2 Computer Science Pub Date : 2015-01-01 DOI: 10.16383/J.AAS.2015.C150278
Huang Long, Z. Gang, Li Ning, Zhao Lin
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引用次数: 3
A semi-supervised agglomerative hierarchical clustering method based on dynamically updating constraints 一种基于动态更新约束的半监督聚类分层聚类方法
Q2 Computer Science Pub Date : 2015-01-01 DOI: 10.16383/J.AAS.2015.C140859
Chenxi Zhou, Xun Liang, Jinshan Qi
A semi-supervised agglomerative hierarchical clustering method based on dynamically updating constraints is proposing in this research. Following the existing semi-supervised clustering algorithm, this method uses the must-link and cannot-link constraints. Instead of using the idea that the instances with must-link constraints are pre-clustered before agglomerating with the others, this method employs a more general and reasonable process. Firstly, must-link and cannot-link constraints are expanded to compose a constraints closure. Then, a standard agglomeration instructed by cannot-link constraints is processed. During this procedure, the must-link and cannot-link are dynamically updated according to the intermediate clustering results. This updating process guarantees the validity of the final results. The fundamental advantage of this method is omitting the pre-clustering process of the instances with must-link constraints. This modification ensures that data points gain a more reasonable agglomeration order, which may result in a significant improvement on the clustering results. This research also introduces an implementation of this model based on Ward0s method, leading to the C-Ward algorithm. The experimental analyses on both Artificial simulated datasets and real world datasets show that this method is much better than the others.
提出了一种基于约束动态更新的半监督聚类分层聚类方法。该方法继承了现有的半监督聚类算法,采用了必须链接约束和不能链接约束。这种方法不使用具有必须链接约束的实例在与其他实例聚合之前预先聚集的想法,而是采用更通用和合理的过程。首先,将必须链接约束和不能链接约束展开为约束闭包。然后,对非链接约束下的标准团聚问题进行了处理。在此过程中,根据中间聚类结果动态更新必须链接和不能链接。这一更新过程保证了最终结果的有效性。该方法的根本优点是省去了具有必须链接约束的实例的预聚类过程。这种修改保证了数据点获得更合理的聚类顺序,这可能会显著改善聚类结果。本研究还介绍了一种基于Ward0s方法的模型实现,从而引出了C-Ward算法。在人工模拟数据集和实际数据集上进行的实验分析表明,该方法比其他方法都要好得多。
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引用次数: 2
State Feedback Stabilization of Stochastic Feedforward Nonlinear Systems with Input Time-delay 输入时滞随机前馈非线性系统的状态反馈镇定
Q2 Computer Science Pub Date : 2014-12-01 DOI: 10.1016/S1874-1029(15)60003-9
Xue-Jun XIE , Cong-Ran ZHAO

In this paper, the problem of state feedback stabilization for stochastic feedforward nonlinear systems with input time-delay is considered for the first time. By introducing a variable transformation, skillfully combining the homogeneous domination method, and constructing an appropriate Lyapunov-Krasovskii functional, a state feedback controller is developed to guarantee the closed-loop system globally asymptotically stable in probability.

本文首次研究了具有输入时滞的随机前馈非线性系统的状态反馈镇定问题。通过引入变量变换,巧妙地结合齐次控制方法,构造适当的Lyapunov-Krasovskii泛函,开发了一种状态反馈控制器,以保证闭环系统在概率上全局渐近稳定。
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引用次数: 12
Nonlinear Control for Multi-agent Formations with Delays in Noisy Environments 噪声环境下具有时滞的多智能体编队非线性控制
Q2 Computer Science Pub Date : 2014-12-01 DOI: 10.1016/S1874-1029(15)60001-5
Xiao-Qing LU , Yao-Nan WANG , Jian-Xu MAO

In this paper, we investigate the nonlinear control problem for multi-agent formations with communication delays in noisy environments and in directed interconnection topologies. A stable theory of stochastic delay differential equations is established and then some sufficient conditions are obtained based on this theory, which allow the required formations to be gained at exponentially converging speeds with probability one for time-invariant formations, time-varying formations, and time-varying formations for trajectory tracking under a special “multiple leaders” framework. Some numerical simulations are also given to illustrate the effectiveness of the theoretical results.

本文研究了有向互连拓扑中具有通信延迟的多智能体编队的非线性控制问题。建立了随机时滞微分方程的稳定理论,并在此基础上得到了在特殊的“多先导”框架下,定常、时变和时变弹道跟踪所需编队以指数收敛速度以概率1获得所需编队的充分条件。数值模拟结果验证了理论结果的有效性。
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引用次数: 3
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自动化学报
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